How gestational diabetes affects brain blood flow after pregnancy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will compare healthy postpartum women with a history of gestational diabetes to those with an uncomplicated pregnancy using noninvasive cerebral blood flow measurements and targeted microvascular testing. The protocol uses two types of ultrasound to measure cerebral hemodynamics and intradermal microdialysis with local heating to probe peripheral microvascular function as a mechanistic correlate. Participants must be at least 18 years old, delivered within the past five years, and free of current diabetes or several excluded medical conditions and medications. This Phase 1 interventional protocol is focused on physiological measurements to characterize cerebrovascular changes after gestational diabetes rather than testing a therapeutic intervention.

Why it matters

Who can join: the full rules

INCLUSION CRITERIA:

* Post-partum women
* 18 years or older
* Delivered within 5 years from the study visit
* History of gestational diabetes diagnosed by an obstetrician and confirmed according to the American College of Obstetricians and Gynecologists criteria for gestational diabetes OR history of uncomplicated pregnancy (defined as no history of gestational diabetes, hypertensive pregnancy, or other gestational disorder).

EXCLUSION CRITERIA: We exclude participants from both groups for:

* Skin diseases
* Current tobacco use
* Diagnosed or suspected hepatic or metabolic disease including diabetes
* Diagnosed with depression or other mood-related disorders, asthma, chronic obstructive pulmonary disease, cystic fibrosis, or pulmonary fibrosis
* Use of prescribed NSAIDs, statins or other cholesterol-lowering medication, antihypertensive medication, carbonic anhydrase inhibitors, corticosteroids, thyroid medications, antidepressants or mood stabilizers, diuretics, phenothiazines, or benzodiazepines
* History of preeclampsia or gestational hypertension,
* History or family history of panic disorder,
* Currently pregnant
* Body mass index \<18.5 kg/m2,
* Allergy to materials used during the experiment (e.g. latex), known allergies to study drugs.
* History of heavy alcohol use/binge drinking,
* Have planned procedures with radiological contrast,
* Have a major dental procedure/surgery coming up, such as a dental extraction
* Anatomy of the middle cerebral artery or internal carotid artery that prevents adequate ultrasonography and/or and data collection

Where it's running

• Iowa Bioscience Innovation Facility
  Iowa City, Iowa, United States Recruiting

Study contacts

• Study coordinator: Anna Reid-Stanhewicz, PHD
• Email: anna-stanhewicz@uiowa.edu
• Phone: 319-467-1732

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.