Clinical trial Recruiting at 1 site Observational Ages 18 to 100

Diltiazem versus adenosine for treating supraventricular tachycardia in the emergency room

Official title: PERceptions of Diltiazem Versus ADEnosine for Treatment of Supraventricular Tachycardia in the Emergency Department: PERVADE-ED Study

Run by University of Iowa · NCT07086560 · Data updated 2026-11-12

This study will see if IV diltiazem or IV adenosine works better and causes fewer side effects for adults who come to the emergency department with supraventricular tachycardia.

More Supraventricular Tachycardia (SVT) trials

Quick facts

Study typeObservational
Ages18 Years to 100 Years
SexAll
Enrollment100 (estimated)
SponsorUniversity of Iowa
Academic / other
Locations1 site (Iowa City, Iowa)
StatusRecruiting
StartedApril 4, 2025
Main results expectedJune 2027
Study endsDecember 2027
Registry record updatedAugust 21, 2026
Trial IDNCT07086560 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 18 or older who come to the ED with acute SVT and receive IV adenosine and/or IV diltiazem and who can complete surveys in English are ideal candidates.

Probably not a fit

People who are pregnant, incarcerated, non-English speaking, or too medically unstable to complete surveys would not be eligible and are unlikely to benefit from participation.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study compares adults presenting to the emergency department with acute SVT who receive IV adenosine, IV diltiazem, or both, collecting clinical outcomes and patient-reported side effects. Researchers will record treatment success, hemodynamic effects, adverse events, and patients' perceptions of symptom distress after medication. Enrollment is limited to English-speaking adults able to complete surveys and excludes pregnant or incarcerated patients and those too unstable to participate. All study activities occur at the University of Iowa Health Care emergency department.

Why it matters

Potential benefit: If successful, the results could help clinicians choose the medication that stops SVT effectively while causing less patient distress and fewer adverse events.

How similar studies have gone: Direct head-to-head comparisons of adenosine and diltiazem are limited, so this observational comparison addresses a relatively under-studied question rather than following a well-established precedent.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. ED encounter for acute SVT
2. Age \>/= 18 years
3. Receipt of IV adenosine and/or IV diltiazem for SVT in the ED or prehospital setting

Exclusion Criteria:

1. Neurologic status precluding survey participation due to medical instability
2. Pregnant
3. Incarcerated
4. Non-English speaking

Where it's running

  • University of Iowa Health Care
    Iowa City, Iowa, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.