Diltiazem versus adenosine for treating supraventricular tachycardia in the emergency room
Official title: PERceptions of Diltiazem Versus ADEnosine for Treatment of Supraventricular Tachycardia in the Emergency Department: PERVADE-ED Study
Run by University of Iowa · NCT07086560 · Data updated 2026-11-12
This study will see if IV diltiazem or IV adenosine works better and causes fewer side effects for adults who come to the emergency department with supraventricular tachycardia.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 100 Years |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | University of Iowa Academic / other |
| Locations | 1 site (Iowa City, Iowa) |
| Status | Recruiting |
| Started | April 4, 2025 |
| Main results expected | June 2027 |
| Study ends | December 2027 |
| Registry record updated | August 21, 2026 |
| Trial ID | NCT07086560 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 or older who come to the ED with acute SVT and receive IV adenosine and/or IV diltiazem and who can complete surveys in English are ideal candidates.
✕Probably not a fit
People who are pregnant, incarcerated, non-English speaking, or too medically unstable to complete surveys would not be eligible and are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study compares adults presenting to the emergency department with acute SVT who receive IV adenosine, IV diltiazem, or both, collecting clinical outcomes and patient-reported side effects. Researchers will record treatment success, hemodynamic effects, adverse events, and patients' perceptions of symptom distress after medication. Enrollment is limited to English-speaking adults able to complete surveys and excludes pregnant or incarcerated patients and those too unstable to participate. All study activities occur at the University of Iowa Health Care emergency department.
Why it matters
Potential benefit: If successful, the results could help clinicians choose the medication that stops SVT effectively while causing less patient distress and fewer adverse events.
How similar studies have gone: Direct head-to-head comparisons of adenosine and diltiazem are limited, so this observational comparison addresses a relatively under-studied question rather than following a well-established precedent.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. ED encounter for acute SVT 2. Age \>/= 18 years 3. Receipt of IV adenosine and/or IV diltiazem for SVT in the ED or prehospital setting Exclusion Criteria: 1. Neurologic status precluding survey participation due to medical instability 2. Pregnant 3. Incarcerated 4. Non-English speaking
Where it's running
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University of Iowa Health Care
Iowa City, Iowa, United States Recruiting
Study contacts
- Study coordinator: Anne Zepeski, PharmD
- Email: anne-zepeski@uiowa.edu
- Phone: 651-207-9357
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.