Evaluating genetic factors in patients with calcium phosphate kidney stones

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the genetic abnormalities present in patients who form calcium phosphate kidney stones, a less common type of stone. It aims to determine whether these genetic factors contribute to the formation of stones, which could lead to improved management and prevention strategies. Participants will undergo genetic testing to identify any abnormalities linked to their condition. The study focuses on patients with a specific urine pH and stone composition, providing a targeted approach to understanding this issue.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Any patient, aged 18-90 and not incarcerated, under the care of a urologist at UIHC with known kidney stone composition including \>=60% calcium phosphate and baseline 24 hour urine pH of \>=6.3

Exclusion Criteria:

\- Any patient over the age of 90 years old, incarcerated or without any evidence of calcium phosphate stone composition

* No struvite component on prior stone analysis
* No bacteria with urease producing organism at time of stone removal
* No history or evidence of systemic acidosis
* No use of acetazolamide, topiramate, zonisamide, valproic acid
* Stage \>=3 CKD (GFR\<60)
* Hepatic disease
* Pregnancy
* History of osteoporosis

Where it's running

• University of Iowa
  Iowa City, Iowa, United States Recruiting

Study contacts

• Study coordinator: Ryan Steinberg, MD
• Email: ryan-steinberg@uiowa.edu
• Phone: 3196787089

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.