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Clinical trials and research at University Health Network, Toronto

• 216Clinical trials
• 1New in 30 days
• 21Countries

Newest trials

All recruiting trials (newest 150 of 216)

• Improving Sleep for Older Adults in the Emergency Department

  This project tests whether wearing a Fitbit overnight can help understand and improve sleep for adults 70 and older in the emergency department who are likely to be admitted.

  Recruiting at 2 sites University Health Network, Toronto · Toronto, Ontario and 1 other locations · NCT07928141

• Can miRNA-371a-3p tell us which small testicular masses need surgery or can be watched?

  This study tests whether the miRNA-371a-3p biomarker can help decide if small testicular masses (≤2 cm) are cancer and should be treated with surgery or followed with surveillance.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07852871

• Effects of excitatory and inhibitory LIFUS of GPi in Parkinson’s patients without DBS

  This study tests two deep-brain focused ultrasound patterns on people with Parkinson’s to see if they change task performance and tremor, compared with a sham stimulation.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07846007

• Co-Adaptation of a Digital Pain Program for Canadian Veterans

  We’re testing whether a self-guided digital pain management program, delivered through the Manage My Pain app, is acceptable and useful for Canadian Veterans with chronic pain.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07818980

• Vagina-View helps guide multichannel applicator placement during vaginal brachytherapy

  This study tests whether the Vagina-View device can visualize vaginal tumors and help place the MCA more precisely during brachytherapy for vaginal cancer.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07818850

• Isunakinra Plus Pembrolizumab Neoadjuvant Therapy for TNBC

  This trial tests whether adding isunakinra to pembrolizumab-based neoadjuvant chemotherapy can help treat newly diagnosed, locally advanced triple-negative breast cancer.

  Recruiting Phase 1/2 University Health Network, Toronto · Toronto, Ontario · NCT07698106

• Pain Reprocessing Therapy for Chronic Low Back Pain

  This study tests whether Pain Reprocessing Therapy can help adults with chronic low back pain by comparing it to a monitoring and education program over eight weeks.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07696741

• Pedunculopontine Nucleus Transcranial Ultrasound Stimulation for Freezing of Gait in Parkinson's

  This study tests whether targeted ultrasound stimulation of the Pedunculopontine nucleus can reduce freezing of gait in people with Parkinson’s disease.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07695233

• Targeted Focused Ultrasound for Cervical Dystonia

  This trial tests whether applying theta burst focused ultrasound to brain regions GPi or DN, or a sham, can help people with cervical dystonia.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07690514

• Well-being program for caregivers of patients with advanced heart or lung disease

  This study tests an 8-week, home-based wellness program delivered virtually to caregivers of people with advanced cardiac or pulmonary disease to see if it’s feasible and acceptable.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07685912

• IV contrast-enhanced CBCT with HyperSight for image guidance in advanced cancer radiotherapy

  This study tests whether giving IV contrast during cone-beam CT helps doctors see the tumor better during radiotherapy in people with advanced cancer.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07648160

• Shoulder Nerve Block Experience After Keyhole Surgery

  This study asks adults who had outpatient shoulder arthroscopic surgery with a single-shot nerve block to share their pain and recovery experiences to see if a nerve catheter might help some patients longer after surgery.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07641842

• Single-session celiac plexus SBRT using a simulation-free adaptive workflow for cancer-related pain

  A pilot test to see if a one-day, simulation-free adaptive radiotherapy process can safely deliver celiac plexus SBRT to adults with advanced pancreatic or other cancers.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07636382

• Capecitabine for MRD-positive, resected ER+/HER2-negative breast cancer

  This Phase 2 trial tests whether taking capecitabine can help people with resected, ER-positive/HER2-negative breast cancer who still have molecular residual disease after standard therapy.

  Recruiting Phase 2 University Health Network, Toronto · Toronto, Ontario · NCT07631052

• SABR vs standard care for early liver cancer

  We’re testing whether a precise radiotherapy approach (SABR) can better control a single early liver tumor than the current treatments that use heat or liver-directed therapies.

  Recruiting at 2 sites University Health Network, Toronto · Waratah and 1 other locations · NCT07628751

• Breath-hold technique to improve radiation accuracy for abdominal cancers

  This study tests whether using inhale and exhale breath holds during SBRT can better target abdominal tumors while protecting nearby organs.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07594691

• AI-assisted gastric POCUS: distinguishing full vs empty stomach

  Researchers are testing an AI tool to help anesthesiologists tell if the stomach is full or empty using bedside ultrasound in healthy adults.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07580456

• Ketamine with DBT for suicidality in adults with treatment-resistant depression or bipolar disorder and BPD

  This study tests whether four ketamine infusions plus Dialectical Behavioural Therapy can more quickly reduce suicidal thoughts in adults with Borderline Personality Disorder and treatment-resistant depression or bipolar disorder.

  Recruiting Phase 2 University Health Network, Toronto · Toronto, Ontario · NCT07569198

• Women-Focused Education in Cardiac Rehab

  This pilot test checks if a women-focused education program added to standard cardiac rehab is feasible and helps women improve heart-health knowledge, quality of life, and healthy behaviors.

  Recruiting University Health Network, Toronto · Barrie, Ontario and 2 other locations · NCT07550036

• Tamoxifen to speed testosterone recovery after ADT in men with prostate cancer

  Tamoxifen is being tested to see if it helps men who have been on androgen deprivation therapy regain normal testosterone faster after treatment.

  Recruiting Phase 2 University Health Network, Toronto · Toronto, Ontario · NCT07535905

• Using HyperSight imaging and Ethos adaptive planning during radiation therapy for children

  This pilot will test whether adding twice-weekly HyperSight CBCT scans and Ethos adaptive planning can help tailor radiation treatment for children and teenagers with non-cranial cancers.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07528547

• High-precision detection of leftover cancer using a liquid-biopsy platform (SHERLOCK)

  This project will test whether sensitive blood and other fluid tests for circulating tumor DNA can find leftover cancer (minimal residual disease) in adults treated with curative intent for breast, lung, melanoma, gynecologic, or genitourinary cancers.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07524114

• Heart Rate Variability as a Marker to Guide High-Flow Nasal Cannula Therapy

  We’re testing whether heart rate variability can help decide the right flow rate for high-flow nasal cannula in adults with respiratory failure.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07518862

• Fecal Transplants for CAR-T Therapy and Stem Cell Transplant Patients

  This pilot test will try fecal microbiota transplantation to see if it's safe and feasible for adults with B-cell lymphoma getting CAR-T therapy or AML/MDS patients undergoing allogeneic stem cell transplantation.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07509450

• Virtual exercise program to help with chemotherapy-induced nerve symptoms

  This trial tests whether a remote, personalized exercise program (EX-CIPN) can reduce CIPN symptoms and related disability in cancer survivors who have persistent neuropathy after chemotherapy, compared with usual care.

  Recruiting Phase 3 University Health Network, Toronto · Toronto, Ontario · NCT07481149

• Cervicothoracic Sympathetic Block for Post-CCOVID Condition

  This study tests whether a cervicothoracic sympathetic block with local anesthetic can help people who have ongoing post-CCOVID symptoms.

  Recruiting Phase 4 University Health Network, Toronto · Toronto, Ontario and 1 other locations · NCT07468604

• Rehabilitation program for allogeneic bone marrow transplant patients

  This trial will test whether the CaRE-4-alloBMT rehab program helps adults having allogeneic bone marrow transplants recover better than usual care.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07457866

• Liposomal Curcumin in Multiple Myeloma: safety and dose finding

  This trial tests a novel liposomal curcumin infusion to see if it is safe and what highest tolerable dose is for adults whose multiple myeloma has returned or not responded to treatment.

  Recruiting Phase 1 University Health Network, Toronto · Toronto, Ontario · NCT07456605

• Understanding Exacerbations in Heart Failure: Monitoring with Apple Watch

  This study tests whether data from an Apple Watch, combined with clinical information, can help predict worsening heart failure in adults living with the condition.

  Recruiting University Health Network, Toronto · Newmarket, Ontario and 2 other locations · NCT07447908

• STEP2 versus routine early palliative care for people with advanced cancer

  This tests whether STEP2—online symptom screening with targeted palliative referrals—works as well as giving all eligible patients routine early palliative care for people with advanced cancer.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07446660

• Lattice radiation versus conventional radiation to relieve symptoms from large solid tumors.

  This trial tests whether lattice (spatially fractionated) radiotherapy gives better pain relief than conventional radiotherapy for people with solid tumors at least 5 cm who need palliative radiation.

  Recruiting Phase 3 University Health Network, Toronto · Toronto, Ontario · NCT07444775

• Cerebellar deep brain stimulation to improve ataxia and walking

  This study will try placing adjustable deep brain stimulation devices in the cerebellum to see if they improve walking and coordination in adults with primary ataxia.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07427563

• Low-intensity focused ultrasound for movement and seizure disorders

  This trial will try low-intensity focused ultrasound (LIFUS) to see if it can safely change brain activity in people with movement disorders or epilepsy.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07417280

• Biofeedback training to improve vision in glaucoma

  This study will test whether short sessions of visual biofeedback training can help people with glaucoma improve fixation stability, retinal sensitivity, and everyday vision.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07409077

• Testing a B7‑H3 antibody–drug conjugate alone and with dostarlimab in recurrent/metastatic head and neck squamous cell carcinoma

  It tests an antibody–drug conjugate called GSK5764227 by itself or with the immunotherapy dostarlimab in adults with recurrent or metastatic head and neck squamous cell carcinoma who have received prior treatments.

  Recruiting Phase 2 University Health Network, Toronto · Toronto, Ontario · NCT07408063

• Radiofrequency Ablation for Small Low-Risk Papillary Thyroid Cancer

  This pilot study tests whether using radiofrequency ablation can cure small, low-risk papillary thyroid cancers in adults who choose not to have surgery or active surveillance.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07376837

• Cognitive stepped care program for adults with brain metastases

  This project will test whether routine screening plus a stepped program of education and tailored cognitive support can help adults with brain metastases manage thinking and memory problems.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07355348

• Daily adaptive radiotherapy to spare the submandibular gland in head and neck cancer

  This study tests whether daily adaptive radiotherapy can better protect the submandibular gland and reduce dry mouth for adults having curative radiotherapy for head and neck squamous cell carcinoma.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07348887

• Micro‑ultrasound guided focal laser treatment for intermediate‑risk prostate cancer

  This will see if micro‑ultrasound–guided focal laser ablation can safely treat men with intermediate‑risk prostate cancer and delay or avoid surgery or radiation.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07339943

• IL-6 guided dexamethasone or tocilizumab treatment for hospitalized acute hypoxemic respiratory failure

  This study will test whether measuring IL-6 to guide early treatment with dexamethasone or tocilizumab helps adults hospitalized with new acute hypoxemic respiratory failure.

  Recruiting Phase 2 University Health Network, Toronto · Toronto, Ontario · NCT07334379

• Combined augmented reality and electrical stimulation to improve hand and arm function after cervical spinal cord injury

  This project will test whether a combined augmented reality (AR) and functional electrical stimulation (FES) system can help people with chronic cervical spinal cord injury improve their upper-limb grasping and everyday hand use over 20 one-hour sessions.

  Recruiting Early Phase 1 University Health Network, Toronto · Toronto, Ontario · NCT07299734

• Video versus phone education for people getting breast radiotherapy

  This study will test whether a 45-minute videoconference education session, compared with a 30-minute phone call, reduces treatment fears and improves satisfaction for adults receiving breast radiotherapy.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07255196

• Letermovir plus standard antiviral to clear CMV in lung transplant recipients

  This will test whether adding letermovir to usual antiviral treatment helps clear CMV in lung transplant recipients with active infection by week 3.

  Recruiting Phase 4 University Health Network, Toronto · Toronto, Ontario · NCT07235683

• Temperature-controlled heart preservation system vs ice for primary graft dysfunction

  This study tests whether using the Xo Port Organ Preservation System can reduce severe graft dysfunction after heart transplant compared with traditional ice storage in adult recipients.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07230886

• UV-treated, antiviral-protected lungs from Hepatitis B–positive donors for transplant

  This will try using lungs from hepatitis B–positive donors that are treated with UV light during ex vivo lung perfusion plus post-transplant antiviral medicines to see if they can be safely transplanted into HBV-negative lung transplant candidates.

  Recruiting Phase 4 University Health Network, Toronto · Toronto, Ontario · NCT07189377

• Enhancing balance in multiple sclerosis with training plus electrical stimulation

  This trial will test whether adding leg muscle stimulation and/or noninvasive spinal stimulation to balance training helps adults with multiple sclerosis who have balance or walking trouble.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07174973

• Focused radiotherapy to control a few growing melanoma spots

  This trial tries adding stereotactic or short-course radiotherapy to up to ten extracranial melanoma spots that are starting to grow while patients stay on their current systemic therapy to see if it delays overall disease progression.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07112170

• Autologous Cold-Stored Platelets for Complex Cardiac Surgery

  This study tests whether using a patient’s own cold-stored platelets, donated 7–10 days before surgery, improves outcomes for adults undergoing complex cardiac procedures compared with standard allogeneic platelets.

  Recruiting Phase 2/3 University Health Network, Toronto · Toronto, Ontario · NCT07064954

• PEARL therapy for caregivers of patients with advanced cancer

  This study tests a one-time high-dose psilocybin session paired with PEARL therapy to help caregivers of people with advanced cancer see if it lowers distress and improves well-being.

  Recruiting Phase 2 University Health Network, Toronto · Toronto, Ontario · NCT07048743

• Measuring breathing effort before and after removing the breathing tube

  This will test a new electrical impedance method to measure breathing effort in adults on ventilators as they try breathing on their own and after the breathing tube is removed.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07017608

• ABSK043, an oral PD-L1 inhibitor for angiogenic sarcomas

  This trial will test whether the oral PD-L1 drug ABSK043 can help adults with advanced angiogenic sarcomas that cannot be removed or have spread.

  Recruiting Phase 2 University Health Network, Toronto · Toronto, Ontario · NCT07014137

• Biofeedback training for vision loss after brain injury

  This study is testing if biofeedback training can help people with vision loss from brain injuries see better and improve their quality of life.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06995313

• Using electrical stimulation to improve balance after stroke

  This study is testing if using electrical stimulation along with balance training can help people who have had a stroke improve their balance and reduce their risk of falling.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06987682

• Porphysome nanoparticle imaging for advanced gynecological cancers

  This will test whether porphysome and copper-64–labelled porphysome nanoparticles can safely help image metastatic or advanced gynecological cancers with PET/CT scans in adults.

  Recruiting Phase 1 University Health Network, Toronto · Toronto, Ontario · NCT06977126

• Deep brain stimulation for Alzheimer's disease

  This study is testing if a new brain stimulation technique can help improve memory and thinking skills in people with mild Alzheimer's disease.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06936124

• Using radiofrequency ablation to treat low-risk thyroid cancer

  This study is testing if a new treatment called radiofrequency ablation can safely help people with low-risk thyroid cancer that is 2 cm or smaller instead of traditional surgery.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06929650

• Hi-OxSR to treat post-COVID cognitive problems

  This trial will test whether using the Hi-OxSR breathing device can help adults with long COVID who have ongoing cognitive problems and fatigue.

  Recruiting at 3 sites University Health Network, Toronto · Edmonton, Alberta and 2 other locations · NCT06928506

• Stereotactic body radiation versus changing systemic therapy for oligoprogressive castrate-resistant prostate cancer

  This will try stereotactic body radiotherapy (SBRT) to all oligoprogressive spots while patients stay on their current systemic therapy to see if that controls disease better than switching systemic therapy in men with castration-resistant oligoprogressive prostate cancer.

  Recruiting Phase 2 University Health Network, Toronto · Toronto, Ontario · NCT06927635

• Oral CBD and THC for hip or knee osteoarthritis pain

  This study will test whether taking a daily oral CBD or THC capsule can reduce pain interference in adults aged 40–80 with hip or knee osteoarthritis.

  Recruiting at 3 sites University Health Network, Toronto · Toronto, Ontario and 2 other locations · NCT06878417

• Virtual Sexual Health and Rehabilitation eClinic for Prostate Cancer Patients

  This study is testing a virtual clinic that helps prostate cancer patients and their partners manage sexual health issues after treatment to see if it improves their sexual function and relationship satisfaction.

  Recruiting at 6 sites University Health Network, Toronto · Vancouver, British Columbia and 9 other locations · NCT06877598

• PET/MR with a CXCR4 tracer versus standard PET/CT and MRI for initial staging and follow-up in multiple myeloma

  This test will see if a PET/MR scan using a new tracer called [68Ga]Ga-PentixaFor finds multiple myeloma in bones more accurately than standard PET/CT and MRI for adults at diagnosis or follow-up.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06871176

• Comparing two doses of corticosteroids for frozen shoulder treatment

  This study is testing whether two different doses of a steroid injection can help people with frozen shoulder feel less pain and move their shoulder better.

  Recruiting Phase 3 University Health Network, Toronto · Toronto, Ontario · NCT06848374

• Adaptive SBRT to para‑aortic and iliac lymph nodes to help prostate cancer responses last longer.

  This study will try CT-guided, online adaptive SBRT to the tumor and nearby at-risk lymph nodes to see if men with oligorecurrent para‑aortic or common iliac nodal prostate cancer get longer-lasting control.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06831032

• Comparing adaptive SBRT to standard image-guided SBRT for localized prostate cancer

  This study is testing if a new type of targeted radiation therapy for prostate cancer can improve urinary health compared to the standard radiation treatment.

  Recruiting Phase 3 University Health Network, Toronto · Toronto, Ontario · NCT06825091

• Lung wash and tumor fluid markers for sarcoma lung metastases

  This study will test whether lung wash (bronchoalveolar lavage) and tumor fluid biomarkers can indicate how much metastatic soft tissue sarcoma is in the lungs for adults having lung surgery.

  Recruiting Phase 2 University Health Network, Toronto · Toronto, Ontario · NCT06815666

• Using Patient-Derived Tumor Organoids to Choose a Drug for Pancreatic Cancer

  This study tests whether selecting a drug based on a patient’s tumor organoids helps people with advanced pancreatic cancer respond to treatment.

  Recruiting Phase 2 University Health Network, Toronto · Toronto, Ontario · NCT06813079

• Tarlatamab for recurrent IDH‑mutant astrocytoma and oligodendroglioma

  This trial will try tarlatamab, an immune‑engaging drug, in adults with recurrent or refractory IDH‑mutant astrocytoma or oligodendroglioma to see if it shrinks tumors or slows progression.

  Recruiting Phase 2 University Health Network, Toronto · Toronto, Ontario · NCT06776250

• Improving sleep health before elective surgery

  This study is testing if helping people improve their sleep before elective surgery can lead to better sleep quality and recovery compared to standard care.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06762639

• Using Radialis PET imaging to assess amyloid plaque in the brain

  This study is testing a new type of brain scan called Radialis PET to see if it can measure amyloid plaque in people with cognitive impairment, like Alzheimer's disease, as well as the standard scan.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06757569

• Blood test for early cancer detection in hereditary cancer patients

  This study is testing a new blood test to see if it can help find early tumors in people with hereditary cancer syndromes better than the usual methods.

  Recruiting at 7 sites University Health Network, Toronto · Vancouver, British Columbia and 7 other locations · NCT06726642

• Combining radiotherapy and immunotherapy for advanced liver cancer before transplant

  This study is testing if combining radiation therapy with immunotherapy can help people with advanced liver cancer get better and qualify for a liver transplant.

  Recruiting Phase 1/2 University Health Network, Toronto · London, Ontario and 1 other locations · NCT06725121

• Supportive housing program for unhoused adults with complex health needs

  This study tests whether a supportive housing program can help unhoused adults with complex health needs use healthcare services better and improve their overall well-being.

  Recruiting at 2 sites University Health Network, Toronto · Toronto, Ontario and 1 other locations · NCT06723093

• Audit of medical waste disposal in surgery at Toronto Western Hospital

  This study looks at the types and amounts of waste created during surgeries at Toronto Western Hospital to see how well staff are managing it and if better education can help reduce waste.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06680284

• Chemoimmunotherapy followed by surgery for limited spread esophageal and gastric cancer

  This study is testing if a combination of chemotherapy, immunotherapy, and surgery can help people with a limited spread of esophageal or gastric cancer live longer and have fewer recurrences.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06668454

• Pneumonitis Prevention with Pentoxifylline and Vitamin E in Stage III NSCLC with Chemoradiation

  This trial tests whether adding pentoxifylline and vitamin E can help prevent radiation-induced lung injury in adults with stage III non-small cell lung cancer who are receiving chemoradiation and planned immune therapy.

  Recruiting Phase 2 University Health Network, Toronto · Toronto, Ontario · NCT06634056

• Identifying liver transplant issues using a blood test

  This study is testing a blood test that looks at gene information to see if it can help doctors find liver problems earlier in patients who have had a liver transplant.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06557564

• Predicting disease progression in dementia using biomarkers and modeling

  This study is trying to create a tool that helps predict how dementia will progress in people with mild cognitive impairment and different types of dementia, like Alzheimer's and Lewy Body Disease, by looking at brain scans, body fluids, and mental tests.

  Recruiting University Health Network, Toronto · North York, Ontario and 3 other locations · NCT06529744

• Exploring the link between emotion, memory, and chronic facial pain

  This study is trying to see how chronic facial pain affects memory and emotions by looking at brain changes in people with trigeminal neuralgia.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06518421

• Evaluating risks of myelodysplastic syndrome in patients receiving peptide radionuclide therapy

  This study is trying to find out if certain patients who receive a specific cancer treatment are at risk of developing blood disorders like myelodysplastic syndrome and leukemia, to make the treatment safer for everyone.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06510868

• High-Dose-Rate Brachytherapy for Prostate Cancer Recurrence

  This study is testing a new way to treat prostate cancer that has come back after previous radiation therapy, using a special type of targeted radiation guided by MRI to see if it helps patients feel better and improve their health.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06508567

• Transplanting parathyroid glands to treat severe hypoparathyroidism

  This study is testing if transplanting parathyroid glands from donors can help people with severe hypoparathyroidism who haven't found relief from other treatments.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06499246

• Training to improve arm and hand function after stroke

  This study is testing a special training program to see if it can help people who have had a stroke improve their arm and hand function better than a regular home exercise program.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06498011

• Effects of Delayed Elective Radiotherapy on Head and Neck Cancer Biomarkers

  This study is testing whether starting radiation therapy later helps people with newly diagnosed head and neck cancer by looking at changes in their tumors and immune markers during treatment.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06487403

• Early palliative care for patients with multiple myeloma and aggressive lymphoma

  This study is testing if early palliative care can improve the quality of life and comfort for people with multiple myeloma and aggressive lymphoma while they receive their usual cancer treatment.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06485076

• Improving arm and hand recovery after spinal cord injury using therapy and stimulation

  This study is testing if combining special therapy with spinal cord stimulation can help people with cervical spinal cord injuries recover better use of their arms and hands.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06472986

• Evaluating a psychological intervention for ovarian cancer patients

  This study is testing a new therapy called CALM to see if it helps people who have just been diagnosed or have had a recurrence of advanced ovarian cancer feel better and cope with their situation.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06459271

• High-dose radiation therapy for advanced pancreatic cancer after chemotherapy

  This study tests whether high-dose radiation therapy can help people with advanced pancreatic cancer who responded well to chemotherapy feel better and live longer.

  Recruiting at 2 sites Phase 2 University Health Network, Toronto · Toronto, Ontario and 1 other locations · NCT06453486

• Hyperbaric oxygen therapy for Long COVID cognitive symptoms

  This study will test whether hyperbaric oxygen therapy can improve lingering cognitive symptoms like brain fog and memory problems in adults who had COVID-19.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06452095

• Using NanoKnife technology to treat intermediate-risk prostate cancer

  This study is testing if a new treatment using NanoKnife technology can safely target and damage tumor cells in men with intermediate-risk prostate cancer.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06451445

• Evaluating complications related to extubation procedures

  This study is trying to find out how often problems happen after removing breathing tubes in patients who have had surgery or are critically ill, to help make the process safer.

  Recruiting University Health Network, Toronto · Tucson, Arizona and 34 other locations · NCT06442930

• Comparing two types of post-operative radiotherapy for prostate cancer

  This study is testing two different schedules of radiotherapy for men with prostate cancer after surgery to see which one works better for their recovery.

  Recruiting at 3 sites Phase 2 University Health Network, Toronto · London, Ontario and 2 other locations · NCT06409910

• Topical tranexamic acid versus placebo to reduce acute pain after volar fixation of distal radius fractures

  This will try placing topical tranexamic acid into the surgical wound to see if it reduces post-operative pain and opioid use for adults having volar open reduction and internal fixation of a distal radius fracture.

  Recruiting Phase 4 University Health Network, Toronto · Toronto, Ontario · NCT06384456

• Using Belimumab to treat Autoimmune Hepatitis

  This study is testing if Belimumab can help people with autoimmune hepatitis feel better and improve their liver function when other treatments haven't worked.

  Recruiting at 6 sites Phase 2 University Health Network, Toronto · Calgary, Alberta and 5 other locations · NCT06381453

• Greater occipital nerve block to relieve headaches from spontaneous intracranial hypotension

  This will try a bilateral ultrasound-guided greater occipital nerve block in adults with spontaneous intracranial hypotension to see if it quickly reduces upright headache.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06374524

• Improving lung transplant outcomes with inspiratory muscle training

  This study tests if a special breathing exercise program can help people waiting for a lung transplant breathe better and recover more smoothly after surgery.

  Recruiting at 4 sites University Health Network, Toronto · Edmonton, Alberta and 3 other locations · NCT06370832

• Emotion and Symptom-Focused Engagement (EASE) for parents of children with cancer

  This trial will test whether adding the EASE psychotherapy to usual care helps parents of children newly diagnosed or relapsed with cancer have fewer traumatic stress symptoms over six months.

  Recruiting University Health Network, Toronto · Toronto, Ontario and 1 other locations · NCT06367556

• Ultra-high dose MR-guided single-session radiation for liver metastases

  This trial will test whether one very high‑dose MR‑guided radiation session works better than a high‑dose approach for adults with up to three liver metastases.

  Recruiting Phase 3 University Health Network, Toronto · Toronto, Ontario · NCT06362395

• PSMA and FDG PET imaging for advanced prostate cancer

  This trial will test whether combining PSMA and FDG PET scans can better show tumor biology and help guide treatment for men with advanced prostate cancer.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06335914

• Detecting and clearing residual disease in high-risk melanoma patients

  This study is testing if a new combination treatment for high-risk melanoma can help patients with leftover cancer cells in their blood feel better compared to the usual treatment.

  Recruiting Phase 2 University Health Network, Toronto · Toronto, Ontario · NCT06319196

• Using intravenous iron to treat anemia after heart surgery

  This study is testing if giving intravenous iron to patients with anemia after heart surgery can help them stay out of the hospital and feel better.

  Recruiting at 3 sites Phase 2 University Health Network, Toronto · Kingston, Ontario and 2 other locations · NCT06287619

• Collecting data on advanced and rare cancers treated with personalized medicine

  This study is trying to see how people with advanced and rare cancers respond to personalized treatments when they have run out of other options.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06285500

• Digital counseling for chronic kidney disease self-care and education

  This study is testing a digital counseling program to see if it can help people with severe chronic kidney disease take better care of themselves and choose home dialysis options compared to regular care.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06274710

• Evaluating Liquid Biopsy and Positron Emission Mammography for High-risk Breast Cancer Detection

  This study is testing two new tests, a blood test and a special imaging scan, to see if they can help women at high risk for breast cancer find it earlier.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06268405

• Program of care for patients with COPD after hospital discharge

  This study is testing a new care program that uses technology to help patients with COPD after they leave the hospital to see if it can keep them healthier and reduce the chances of going back to the hospital.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06253013

• Outpatient teclistamab treatment plan for relapsed or refractory multiple myeloma

  This pilot will try giving teclistamab to adults with relapsed or refractory multiple myeloma in an outpatient clinic to see if it can be delivered safely and practically while measuring effects on caregivers.

  Recruiting Phase 4 University Health Network, Toronto · Toronto, Ontario · NCT06251076

• Comparing two types of needles for diagnosing sarcoidosis

  This study is testing whether a new type of needle works better than a standard needle for diagnosing sarcoidosis in patients with swollen lymph nodes.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06220526

• Testing a new drug for chronic hepatitis B infection

  This study is testing a new drug called VIR-3434 to see if it can help people with chronic hepatitis B infection improve their condition over a year of treatment.

  Recruiting Phase 2 University Health Network, Toronto · Toronto, Ontario · NCT06216470

• Digital peer support for young adults with cancer

  This study is testing a digital support program to see if it can help young adults who have finished cancer treatment by connecting them with trained peers for guidance and encouragement.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06193369

• Early swallowing and speech intervention for head and neck cancer patients after surgery

  This study is testing if early help from speech therapists can improve swallowing and speech for patients with tongue cancer after surgery to prevent complications.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06192771

• Stopping heart failure medications in cancer survivors with heart dysfunction

  This study is testing if cancer survivors with improved heart function can safely stop taking their heart failure medications to see if it reduces their pill burden and side effects.

  Recruiting at 8 sites Phase 4 University Health Network, Toronto · Los Angeles, California and 13 other locations · NCT06183437

• Evaluating Zanubrutinib and Tislelizumab for Progressive Lymphoma After CAR-T Therapy

  This study is testing whether a combination of zanubrutinib and tislelizumab can help people with large B-cell lymphoma who have not responded well after CAR-T therapy.

  Recruiting Phase 2 University Health Network, Toronto · Toronto, Ontario · NCT06167785

• Investigating the link between brain activity and breathing volume in humans

  This study is testing how different amounts of air from a ventilator affect brain activity in critically ill patients to see if it could help prevent brain injury.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06142773

• Using vitamin C to reduce pain after knee surgery

  This study is testing if giving vitamin C to people before and after knee surgery can help reduce their pain and improve their quality of life.

  Recruiting at 3 sites Phase 2 University Health Network, Toronto · Toronto, Ontario and 2 other locations · NCT06123715

• Exploring MRI and Biomarkers in Head and Neck Cancer Treatment

  This study is testing how MRI scans and certain biological markers can help doctors understand how well treatments are working for people with newly diagnosed head and neck cancer.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06085781

• Using Indocyanine Green for Lymph Node Biopsy in Breast Cancer After Chemotherapy

  This study is testing if a special dye called Indocyanine Green can help doctors find lymph nodes more accurately during breast cancer surgery after chemotherapy, compared to the usual methods.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06085274

• Weight-loss drug plus progestin for fertility-sparing endometrial hyperplasia/cancer

  This phase 2 trial tests whether adding a GLP-1 weight-loss drug (semaglutide) to progestin therapy helps young, overweight women with endometrial cancer or atypical hyperplasia preserve fertility.

  Recruiting Phase 2 University Health Network, Toronto · Toronto, Ontario · NCT06073184

• Using durvalumab and oleclumab before surgery for pancreatic cancer

  This study is testing if giving two immune-boosting treatments before surgery can help people with pancreatic cancer have better outcomes.

  Recruiting Phase 2 University Health Network, Toronto · Toronto, Ontario · NCT06060405

• MR-guided radiation therapy for anal cancer with tailored treatment

  This study is testing a personalized radiation therapy approach for patients with anal cancer to see if adjusting treatment based on their individual risk levels and biomarkers can improve their outcomes.

  Recruiting Phase 2 University Health Network, Toronto · Pittsburgh, Pennsylvania and 4 other locations · NCT06050707

• Using Glofitamab to Improve Treatment for Untreated Diffuse Large B Cell Lymphoma

  This study is testing if adding a new drug called glofitamab to standard treatment can help people with untreated diffuse large B cell lymphoma have better outcomes.

  Recruiting at 2 sites Phase 2 University Health Network, Toronto · Toronto, Ontario and 2 other locations · NCT06050694

• At-home care for breast cancer patients using an e-health app

  This study is testing whether using a special app for breast cancer patients, along with their regular care, can help them feel more involved in their treatment compared to just receiving standard care alone.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT05989477

• Treatment using engineered T cells for certain types of blood cancer

  This study is testing a new treatment using specially engineered T cells to see if it can help people with certain types of blood cancer that haven't responded to other treatments.

  Recruiting Phase 1 University Health Network, Toronto · Toronto, Ontario · NCT05963217

• Optimizing lymphodepletion for better outcomes in CAR T cell therapy for lymphoma

  This study is testing different ways to prepare patients with Diffuse Large B Cell Lymphoma for CAR T cell therapy to see which method works best for improving their treatment outcomes.

  Recruiting Phase 1 University Health Network, Toronto · Toronto, Ontario · NCT05950802

• Using MRI to predict metastasis in soft tissue sarcoma patients

  This study is testing if a special type of MRI can help doctors see if soft tissue sarcoma patients have low oxygen levels in their tumors, which could help them choose better treatments right from the start.

  Recruiting Phase 2 University Health Network, Toronto · Toronto, Ontario · NCT05950594

• Combination therapy of two diabetes medications in kidney transplant recipients

  This study is testing if a combination of two diabetes medications can help kidney transplant recipients improve their kidney function and heart health.

  Recruiting Phase 2 University Health Network, Toronto · Toronto, Ontario · NCT05938712

• Investigating MRI Biomarkers in Head and Neck Cancer Treatment

  This study is testing if MRI scans can help doctors better tailor treatment for patients with newly diagnosed head and neck cancer to improve their outcomes and reduce side effects.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT05919290

• Virtual rehabilitation program for cancer survivors

  This study is testing an 8-week online rehab program for cancer survivors to see if it helps them feel better physically and socially after treatment.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT05898789

• Using Virtual Reality to Help Caregivers and Improve Quality of Life for People with Dementia

  This study is testing if using virtual reality at home can help caregivers feel less stressed and improve the quality of life for people with dementia.

  Recruiting at 5 sites University Health Network, Toronto · Oakville, Ontario and 6 other locations · NCT05867641

• Comparing two techniques for treating neck pain with radiofrequency neurotomy

  This study is testing two different methods of using radiofrequency treatment to see which one helps adults with chronic neck pain from arthritis feel better.

  Recruiting at 2 sites University Health Network, Toronto · Toronto, Ontario and 2 other locations · NCT05818774

• Using PET-MRI imaging for esophagogastric cancer treatment

  This study is testing whether using PET-MRI imaging during radiation treatment can improve care for patients with esophagogastric cancer.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT05796102

• Investigating the safety and mechanisms of SGLT2 inhibitors in patients on peritoneal dialysis

  This study is testing if a diabetes medication called empagliflozin is safe and helpful for people on peritoneal dialysis who still have some kidney function, to see if it can protect their heart and kidneys.

  Recruiting Phase 3 University Health Network, Toronto · Toronto, Ontario · NCT05715814

• Telemonitoring for high-risk pregnant women in Pakistan

  A mobile phone app called Raabta will let pregnant women at high risk for preeclampsia in Karachi, Pakistan, regularly track blood pressure and share data with clinicians to see if this helps catch problems earlier.

  Recruiting University Health Network, Toronto · Karachi, Sindh · NCT05662696

• Radiation treatment comparison for metastatic prostate cancer

  This study is testing whether getting radiation treatment every other day for two weeks causes different side effects compared to getting it once a week for six weeks in men with metastatic prostate cancer.

  Recruiting Phase 2 University Health Network, Toronto · Toronto, Ontario · NCT05656794

• Reducing respiratory drive using a novel gas flow system

  This study tests a new gas flow system to see if it can help patients on mechanical ventilation breathe better and avoid lung injuries.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT05642832

• Direct chemotherapy delivery to the lungs for colorectal cancer metastases

  This study is testing a new way to deliver chemotherapy directly to the lungs during surgery for people with colorectal cancer that has spread there, to see if it can target cancer cells better while causing fewer side effects.

  Recruiting Phase 1 University Health Network, Toronto · Toronto, Ontario · NCT05611034

• Re-irradiation for breast cancer using a short radiation course

  This study is testing a shorter, one-week radiation treatment for women with recurring breast cancer to see if it is safer and leads to better results than the usual longer treatments.

  Recruiting at 19 sites University Health Network, Toronto · New York, New York and 18 other locations · NCT05592938

• Comparing two types of radiation therapy for spinal cancer

  This study is testing whether a newer type of radiation therapy for spinal cancer works better than the traditional method to help patients manage their pain and improve their survival.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT05589701

• Supportive care for older men with metastatic prostate cancer

  This study is testing whether a special care plan and remote symptom tracking can help older men with advanced prostate cancer feel better when starting or changing their hormone treatments.

  Recruiting at 3 sites University Health Network, Toronto · Toronto, Ontario and 2 other locations · NCT05582772

• Lung transplants from A2 donors to O recipients

  This study is testing if lung transplants from A2 blood type donors can safely help people with O blood type who are waiting for a transplant.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT05581745

• Comparing autologous therapies for knee osteoarthritis treatment

  This study is testing whether two types of treatments using your own cells can help people with knee osteoarthritis feel less pain and move better compared to a saline placebo.

  Recruiting Phase 2/3 University Health Network, Toronto · Toronto, Ontario and 1 other locations · NCT05517434

• Musical intervention for pregnant individuals with epilepsy

  This study tests if participating in a musical program can help pregnant individuals with epilepsy feel less stressed and more empowered during their pregnancy.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT05503290

• Outcomes of Pregnant Individuals With Epilepsy

  This study looks at how following epilepsy care guidelines during pregnancy affects the health of both mothers with epilepsy and their newborns.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT05485649

• Impact of Sleep Efficiency on Motor Impairment in Spinal Cord Injury

  This study is testing if starting CPAP therapy early or later helps people with spinal cord injuries and sleep problems improve their movement abilities.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT05473689

• Combination treatment of Durvalumab and Tremelimumab for liver cancer before surgery

  This study is testing whether a combination of two immune treatments, Durvalumab and Tremelimumab, can help people with early to intermediate liver cancer do better before surgery.

  Recruiting Phase 2 University Health Network, Toronto · Toronto, Ontario and 2 other locations · NCT05440864

• Evaluating new treatments for acute respiratory failure

  This study is testing new treatments for patients with severe breathing problems to see if different ventilation methods can help them survive better in the hospital.

  Recruiting at 100 sites University Health Network, Toronto · Tucson, Arizona and 102 other locations · NCT05440851

• Comparing intravenous and oral acetaminophen for pain management after hip fracture surgery in older adults

  This study is testing whether giving older adults IV acetaminophen or oral acetaminophen after hip fracture surgery helps them manage pain better and recover more effectively.

  Recruiting Phase 4 University Health Network, Toronto · Toronto, Ontario · NCT05425355

• Treatment for advanced head and neck cancer using AZD2936

  This study is testing if a new drug called AZD2936 can help people with advanced head and neck cancer get rid of leftover cancer cells after their initial treatment.

  Recruiting Phase 2 University Health Network, Toronto · Toronto · NCT05414032

• Investigating a new treatment approach for metastatic prostate cancer

  This study is testing if adding a new drug to regular radiation and hormone therapy can help men with metastatic prostate cancer feel better and live longer.

  Recruiting Phase 2 University Health Network, Toronto · Toronto, Ontario and 1 other locations · NCT05404139

• A network for collaborative cancer research in Ontario

  This study is testing a new way to improve cancer treatment by using genetics and technology to help personalize care for people with different types of cancer.

  Recruiting at 2 sites University Health Network, Toronto · Kingston, Ontario and 2 other locations · NCT05403177

• Biofeedback training for improving vision in patients with hemianopia

  This study tests if biofeedback training can help people with vision loss from brain injuries learn to see better by improving how they move their eyes and focus on things.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT05397873

• Using Kadcyla and Neratinib to Treat Early HER2-positive Breast Cancer with Residual Disease

  This study is testing if adding a pill called neratinib to the standard treatment can help people with early HER2-positive breast cancer who still have some cancer cells left after their initial therapy.

  Recruiting Phase 2 University Health Network, Toronto · Toronto, Ontario · NCT05388149

Showing recruiting studies first, then the newest. Describe your situation to find the ones that fit you.

Quick answers

How many clinical trials run by University Health Network, Toronto are recruiting right now?

216, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 21 countries. The most sites are in Canada (215 trials), Australia (6 trials), United States (6 trials), Spain (4 trials), Italy (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 38, Phase 3: 8, Phase 4: 7, Phase 1: 7. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →