Investigating the link between brain activity and breathing volume in humans

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study explores the relationship between the volume of air delivered to the lungs by a ventilator and brain activity in humans. It aims to establish whether changes in tidal volume affect brain activity, particularly in the hippocampus, using MRI scans during general anesthesia. By comparing brain activity at two different tidal volumes, the study seeks to understand the potential for ventilation-associated brain injury in critically ill patients. The findings could pave the way for therapies to mitigate cognitive impairment linked to mechanical ventilation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients scheduled to undergo an MRI scan of their head under general anesthesia
2. Age \> 18 years

Exclusion Criteria:

1. Stroke, and/or brain tumor in the regions of interest that has not been diagnosed before the MRI scan
2. Previous medical history of dementia
3. Previous medical history of brain surgery
4. Acute or chronic spinal cord Injury
5. Previous Vagotomy
6. Phrenic nerve injury

Where it's running

• Toronto General Hospital
  Toronto, Ontario, Canada Recruiting

Study contacts

• Principal investigator: Ewan Goligher, MD — University Health Networ
• Study coordinator: Rongyu ( Cindy) Jin
• Email: rongyu.jin@uhn.ca
• Phone: 416-340-4800

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.