Topical tranexamic acid versus placebo to reduce acute pain after volar fixation of distal radius fractures

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center Phase 4 interventional trial compares topical tranexamic acid applied into the surgical wound to a placebo in adults undergoing volar open reduction and internal fixation for distal radius fractures. Participants receive either topical TXA or placebo at the time of surgery, and postoperative outcomes including pain scores, opioid consumption, and wrist function are collected. Key exclusions include chronic pain disorders, current chronic opioid use, thromboembolic history, pregnancy or breastfeeding, and known allergy to TXA. The trial is conducted at Toronto Western Hospital using standardized perioperative care to limit confounding.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients undergoing open reduction internal fixation (Volar approach) for operative management of a distal radius fracture;
* Aged 18 or older;
* Provision of informed consent;
* Cognitive ability and English-language skills required to complete outcome measures.

Exclusion Criteria:

* Revision surgery or any additional operative management of ipsilateral wrist injury
* Distal radius fracture treated with a dorsal approach
* Known history of lymphedema or lymph node dissection in the operative extremity
* Known chronic pain conditions, fibromyalgia, or polymyalgia rheumatic
* Current user of opioids and/or on chronic opioids use
* Known allergic reaction to TXA
* Anticoagulant use not stopped in time for surgery as per thrombosis Canada guidelines (i.e. warfarin, acetylsalicylic acid, direct oral anticoagulants, etc.)
* Previous thrombotic stroke or thromboembolic disorders (i.e. known previous DVT, PE, or clotting disorders)
* Current pregnancy or breastfeeding
* Previous neurologic injury causing paralysis of affected shoulder/arm
* Severe cardio-respiratory disease (i.e. ASA Grade IV or higher).

Where it's running

• Toronto Western Hospital
  Toronto, Ontario, Canada Recruiting

Study contacts

• Study coordinator: Ryan Paul
• Email: jhanna.bermudez@uhn.ca
• Phone: 416-603-5839

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Cannulated screws versus K-wires for fixing distal radius (wrist) fractures

  This study will test whether cannulated screws or K-wires lead to better arm function and fewer complications in adults (18–60) with displaced extra-articular distal radius fractures.

  Recruiting Sohag University · Sohag, Naser City · NCT07523386

• Fu's subcutaneous needling with rehabilitation to help heal distal radius fractures after closed reduction

  This trial will test whether adding Fu's subcutaneous needling to standard rehabilitation helps adults (18–85) heal distal radius fractures after closed reduction and splinting.

  Recruiting Guangzhou University of Chinese Medicine · Guangzhou, Guangdong · NCT07054463

• Comparing two types of splints for wrist stiffness after a fracture

  This study is testing which type of splint, static progressive or dynamic, helps adults with wrist stiffness after a fracture feel better and move their wrist more easily.

  Recruiting Al Hayah University In Cairo · Cairo · NCT06913933

• Using mechanical devices to manage pain and swelling after wrist surgery

  This study is testing whether using special machines to help with pain and swelling can improve recovery for people who have had wrist surgery for a broken bone.

  Recruiting Al Hayah University In Cairo · Cairo · NCT06913920

• Comparing rehabilitation methods for wrist fractures in younger adults

  This study is testing three different rehab methods for wrist fractures in younger adults to see which one helps them recover better.

  Recruiting Al Hayah University In Cairo · Cairo · NCT06913894

• Evaluating radiological criteria for stability in wrist fractures

  This study tests if certain X-ray and CT scan results can help doctors decide if adults with wrist fractures need surgery after a closed reduction.

  Recruiting Oslo University Hospital · Oslo, Oslo · NCT06617780

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.