Comparing two types of needles for diagnosing sarcoidosis
Official title: A Prospective Randomized Clinical Trial Comparing Menghini-type Needle and Franseen-type Needle for Endobronchial Ultrasound-guided Transbronchial Needle Aspiration for Pathological Diagnosis of Sarcoidosis
Run by University Health Network, Toronto · NCT06220526 · Data updated 2026-11-12
This study is testing whether a new type of needle works better than a standard needle for diagnosing sarcoidosis in patients with swollen lymph nodes.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 128 (estimated) |
| Sponsor | University Health Network, Toronto Academic / other |
| Locations | 1 site (Toronto, Ontario) |
| Status | Recruiting |
| Started | August 18, 2023 |
| Main results expected | February 28, 2027 |
| Study ends | February 28, 2027 |
| Registry record updated | May 1, 2026 |
| Trial ID | NCT06220526 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 or older with enlarged mediastinal and/or hilar lymph nodes suspected of sarcoidosis.
✕Probably not a fit
Patients with lymphadenopathy likely due to other diseases, such as lung cancer or infection, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This pilot clinical trial aims to compare the effectiveness of Franseen-type needles versus the conventional Menghini-type needles for diagnosing sarcoidosis through endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). The study will enroll approximately 128 patients with enlarged mediastinal and/or hilar lymph nodes suspected of having sarcoidosis. Participants will be randomly assigned to receive either needle type, and the quality of the samples collected will be assessed by pathologists. The trial will also monitor procedural safety and efficiency, including total procedure time and the number of needle passes required.
Why it matters
Potential benefit: If successful, this study could improve the diagnostic accuracy and efficiency for patients suspected of having sarcoidosis.
How similar studies have gone: While similar studies have explored needle types in EBUS-TBNA, this specific comparison is novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * -Any adult patient aged 18 years or older with enlarged mediastinal and/or hilar lymph nodes * (≥10 mm short-axis diameter on a CT scan), suspected as having sarcoidosis based on clinical * history, physical exam, and other investigations, and booked for EBUS-TBNA. Exclusion Criteria: * -Patients that are unable to provide informed consent \- Patients with lymphadenopathy strongly suspected to be secondary to other diseases based on * clinical history, physical exam, and/or other investigations (e.g., lung cancer, lymphoma, * infection).
Where it's running
-
Toronto General Hospital
Toronto, Ontario, Canada Recruiting
Study contacts
- Principal investigator: Kazuhiro Yasufuku — Uhn
- Study coordinator: Judy McConnell
- Email: judy.mcconnell@uhn.ca
- Phone: 416-581-7849
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.