Using PET-MRI imaging for esophagogastric cancer treatment
Official title: Feasibility Study of PET-MRI as a Platform for Image Guidance and Adaptive Radiation Therapy in Patients With Esophagogastric Cancer
Run by University Health Network, Toronto · NCT05796102 · Data updated 2026-11-12
This study is testing whether using PET-MRI imaging during radiation treatment can improve care for patients with esophagogastric cancer.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 15 (estimated) |
| Sponsor | University Health Network, Toronto Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Toronto, Ontario) |
| Status | Recruiting |
| Started | March 28, 2023 |
| Main results expected | May 2027 |
| Study ends | May 2027 |
| Registry record updated | March 5, 2026 |
| Trial ID | NCT05796102 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older diagnosed with locally advanced esophageal cancer who are eligible for conventional radiation therapy.
✕Probably not a fit
Patients with contraindications for MRI or gadolinium, those who are pregnant or breastfeeding, or individuals with pacemakers may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the feasibility of incorporating PET-MRI imaging into the radiation treatment workflow for patients with esophagogastric cancer. It involves a single-arm approach where imaging is performed before, during, and after radiation treatment. The goal is to gather data that could enhance future radiation therapy planning and patient care. The study will include up to 15 patients and is conducted at a single center.
Why it matters
Potential benefit: If successful, this study could improve the integration of advanced imaging techniques into radiation therapy for better treatment outcomes in esophagogastric cancer patients.
How similar studies have gone: While this approach is innovative, similar studies have shown promise in utilizing advanced imaging techniques in cancer treatment workflows.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients 18 years or older * Diagnosed with locally advanced esophageal cancer being considered for conventional RT \>4 weeks * Ability and willingness to provide written informed consent Exclusion Criteria: * Contraindication for MRI * Contraindication for Gadolinium (i.e. inability to lie supine for at least 60 minutes) * Any patient who is pregnant or breastfeeding * Pacemaker or implanted defibrillator * Claustrophobia
Where it's running
-
Princess Margaret Cancer Centre
Toronto, Ontario, Canada Recruiting
Study contacts
- Study coordinator: Rebecca K S Wong, MD
- Email: rebecca.wong@uhn.ca
- Phone: 4169462000
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Combination treatment for gastroesophageal junction and esophagogastric cancer
This study is testing a new combination of liposomal irinotecan with standard treatments to see if it helps people with gastroesophageal junction or esophagogastric cancer feel better.
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Chemoradiotherapy for esophageal and esophagogastric junction cancer
This study is testing a new combination of chemotherapy, radiation, and immune therapies to see if it helps people with advanced esophageal or esophagogastric junction cancer live longer and feel better.
-
Using MRI and CT to Evaluate Tumor Response in Esophageal Cancer Treatment
This study tests whether MRI can better track how well treatment is working for people with esophageal cancer compared to regular CT scans.
-
Testing a new drug for patients with advanced solid tumors
This study is testing a new drug called JR8603 to see if it can help people with advanced solid tumors that haven't responded to other treatments.
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Neoadjuvant treatments for esophageal cancer
This study is testing different combinations of treatments for people with esophageal cancer to see if they can improve outcomes compared to just having surgery.
-
Combining PD-1 inhibitors with chemotherapy for advanced gastric cancer treatment
This study is testing if combining a new drug with chemotherapy can help people with advanced stomach cancer feel better and live longer.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.