Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Using PET-MRI imaging for esophagogastric cancer treatment

Official title: Feasibility Study of PET-MRI as a Platform for Image Guidance and Adaptive Radiation Therapy in Patients With Esophagogastric Cancer

Run by University Health Network, Toronto · NCT05796102 · Data updated 2026-11-12

This study is testing whether using PET-MRI imaging during radiation treatment can improve care for patients with esophagogastric cancer.

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Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment15 (estimated)
SponsorUniversity Health Network, Toronto
Academic / other
Drugs / interventionsradiation
Locations1 site (Toronto, Ontario)
StatusRecruiting
StartedMarch 28, 2023
Main results expectedMay 2027
Study endsMay 2027
Registry record updatedMarch 5, 2026
Trial IDNCT05796102 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 18 and older diagnosed with locally advanced esophageal cancer who are eligible for conventional radiation therapy.

Probably not a fit

Patients with contraindications for MRI or gadolinium, those who are pregnant or breastfeeding, or individuals with pacemakers may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the feasibility of incorporating PET-MRI imaging into the radiation treatment workflow for patients with esophagogastric cancer. It involves a single-arm approach where imaging is performed before, during, and after radiation treatment. The goal is to gather data that could enhance future radiation therapy planning and patient care. The study will include up to 15 patients and is conducted at a single center.

Why it matters

Potential benefit: If successful, this study could improve the integration of advanced imaging techniques into radiation therapy for better treatment outcomes in esophagogastric cancer patients.

How similar studies have gone: While this approach is innovative, similar studies have shown promise in utilizing advanced imaging techniques in cancer treatment workflows.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients 18 years or older
* Diagnosed with locally advanced esophageal cancer being considered for conventional RT \>4 weeks
* Ability and willingness to provide written informed consent

Exclusion Criteria:

* Contraindication for MRI
* Contraindication for Gadolinium (i.e. inability to lie supine for at least 60 minutes)
* Any patient who is pregnant or breastfeeding
* Pacemaker or implanted defibrillator
* Claustrophobia

Where it's running

  • Princess Margaret Cancer Centre
    Toronto, Ontario, Canada
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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  • Using MRI and CT to Evaluate Tumor Response in Esophageal Cancer Treatment

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  • Neoadjuvant treatments for esophageal cancer

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    Recruiting Phase 3 Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Beijing · NCT04821843

  • Combining PD-1 inhibitors with chemotherapy for advanced gastric cancer treatment

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    Recruiting Fudan University · Shanghai, Shanghai Municipality · NCT06158919

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.