Evaluating complications related to extubation procedures

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The EXTUBE study is an international, multicenter, prospective cohort investigation focused on understanding the incidence, risk factors, and outcomes associated with complications arising from extubation after general anesthesia or critical illness. It aims to gather systematic data on the frequency and circumstances of severe complications during extubation, which can lead to serious adverse events such as cardiac arrest or brain damage. By analyzing clinical practices and procedural factors, the study seeks to improve the safety and effectiveness of extubation procedures in various settings, including operating rooms and intensive care units.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients (≥18 years old)
* Undergoing extubation of an endotracheal tube (including index extubation and re-extubations) after general anesthesia in the OR, out of OR anesthesia location or ICU
* Undergoing extubation during the specified enrollment window

Exclusion Criteria:

* Patients will be excluded if the extubation is performed in the context of withdrawal of life support measures,
* Patients will be excluded if the extubation is performed for tracheostomy decannulation

For each patient who is not included, reasons for exclusion will be reported.

Where it's running

• University Health Network - Toronto General Hospital
  Toronto, Ontario, Canada Recruiting
• Banner University Medical Centre
  Tucson, Arizona, United States Completed
• University of Arkansas for Medical Sciences
  Little Rock, Arkansas, United States Completed
• University of Florida
  Gainesville, Florida, United States Completed
• The University of Chicago
  Chicago, Illinois, United States Completed
• Oregon Health & Science University
  Portland, Oregon, United States Completed

Study contacts

• Principal investigator: Matteo Parotto, MD, PhD — Uhn
• Study coordinator: Matteo Parotto, MD, PhD
• Email: matteo.parotto@uhn.ca
• Phone: +1 416 340 3567

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• On-hours vs off-hours extubation: comparing acute airway problems after extubation

  This study tests whether extubations done during on-hours have fewer acute airway/respiratory problems in the first 30 minutes after extubation compared with extubations done off-hours in adults undergoing general anesthesia.

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• Endotracheal suctioning during positive-pressure extubation in the ICU

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• Pressure-support versus T-piece breathing test for overweight and obese adults on ventilators

  This test will see if a one-hour pressure-support or T-piece breathing trial helps overweight and obese adults on a ventilator be successfully extubated without needing reintubation within 72 hours.

  Recruiting Taipei Medical University Hospital · Taipei · NCT07114289

• High-flow nasal cannula versus non-invasive ventilation after extubation in children following heart surgery

  This compares high-flow nasal cannula and non-invasive ventilation to see which better prevents reintubation in children after heart surgery.

  Recruiting Universitas Indonesia · Jakarta, DKI Jakarta · NCT07059689

• Using electrical stimulation at acupoints to reduce respiratory issues after anesthesia

  This study is testing if electrical stimulation at certain points on the body can help people recover better from anesthesia by improving their breathing and preventing problems.

  Recruiting Nanjing First Hospital, Nanjing Medical University · Nanjing, Jiangsu and 1 other locations · NCT06772961

• Comparing modified deep extubation to standard awake extubation

  This study is testing if a new way of waking patients up after laparoscopic surgery can help them leave the operating room faster than the usual method.

  Recruiting Samuel Lunenfeld Research Institute, Mount Sinai Hospital · Toronto, Ontario · NCT06318715

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.