Evaluating complications related to extubation procedures
EXtubation Related Complications - an International Observational Study To Understand the Impact and BEst Practices in the Operating Room and Intensive Care Unit - the EXTUBE Study
University Health Network, Toronto · NCT06442930
This study is trying to find out how often problems happen after removing breathing tubes in patients who have had surgery or are critically ill, to help make the process safer.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 3000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Health Network, Toronto (other) |
| Locations | 28 sites (Tucson, Arizona and 27 other locations) |
| Trial ID | NCT06442930 on ClinicalTrials.gov |
What this trial studies
The EXTUBE study is an international, multicenter, prospective cohort investigation focused on understanding the incidence, risk factors, and outcomes associated with complications arising from extubation after general anesthesia or critical illness. It aims to gather systematic data on the frequency and circumstances of severe complications during extubation, which can lead to serious adverse events such as cardiac arrest or brain damage. By analyzing clinical practices and procedural factors, the study seeks to improve the safety and effectiveness of extubation procedures in various settings, including operating rooms and intensive care units.
Who should consider this trial
Good fit: Ideal candidates for this study are adult patients aged 18 and older who are undergoing extubation after general anesthesia or in an ICU setting.
Not a fit: Patients who are having extubation performed as part of withdrawal of life support measures or for tracheostomy decannulation will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could significantly enhance patient safety during extubation by identifying risk factors and improving clinical practices.
How similar studies have performed: While there have been smaller studies on extubation complications, this is one of the first large-scale investigations aimed at systematically analyzing these issues, making it a novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients (≥18 years old) * Undergoing extubation of an endotracheal tube (including index extubation and re-extubations) after general anesthesia in the OR, out of OR anesthesia location or ICU * Undergoing extubation during the specified enrollment window Exclusion Criteria: * Patients will be excluded if the extubation is performed in the context of withdrawal of life support measures, * Patients will be excluded if the extubation is performed for tracheostomy decannulation For each patient who is not included, reasons for exclusion will be reported.
Where this trial is running
Tucson, Arizona and 27 other locations
- Banner University Medical Centre — Tucson, Arizona, United States (COMPLETED)
- University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States (COMPLETED)
- University of Florida — Gainesville, Florida, United States (COMPLETED)
- The University of Chicago — Chicago, Illinois, United States (ACTIVE_NOT_RECRUITING)
- Oregon Health & Science University — Portland, Oregon, United States (COMPLETED)
- The University of Texas Health Science Center — Houston, Texas, United States (COMPLETED)
- Royal North Shore Hospital — Sydney, New South Wales, Australia (COMPLETED)
- The Northern Hospital — Melbourne, Victoria, Australia (COMPLETED)
- Austin Hospital — Melbourne, Victoria, Australia (COMPLETED)
- Eastern Health - Box Hill Hospital — Melbourne, Victoria, Australia (COMPLETED)
- Eastern Health - Maroondah Hospital — Melbourne, Victoria, Australia (COMPLETED)
- Eastern Health - Angliss Hospital — Melbourne, Victoria, Australia (COMPLETED)
- Surrey Memorial Hospital — Surrey, British Columbia, Canada (COMPLETED)
- The Moncton Hospital — Moncton, New Brunswick, Canada (COMPLETED)
- Sunnybrook Hospital — North York, Ontario, Canada (COMPLETED)
- Niagara Health - Marotta Family Hospital — Saint Catharines, Ontario, Canada (COMPLETED)
- St. Michael's Hospital — Toronto, Ontario, Canada (COMPLETED)
- Mount Sinai Hospital — Toronto, Ontario, Canada (COMPLETED)
- University Health Network - Toronto General Hospital — Toronto, Ontario, Canada (COMPLETED)
- University Health Network - Toronto Western Hospital — Toronto, Ontario, Canada (COMPLETED)
- Centre hospitalier de l'Université de Montréal (CHUM) — Montreal, Quebec, Canada (ACTIVE_NOT_RECRUITING)
- Cork University Hospital — Cork, Ireland (RECRUITING)
- Mater Misericordiae University Hospital — Dublin, Ireland (RECRUITING)
- Galway University Hospitals — Galway, Ireland (COMPLETED)
- Southland Hospital — Invercargill, New Zealand (RECRUITING)
- Tan Tock Seng Hospital — Singapore, Singapore (COMPLETED)
- Royal United Hospitals Bath — Bath, United Kingdom (COMPLETED)
- Freeman Hospital — Newcastle upon Tyne, United Kingdom (COMPLETED)
Study contacts
- Principal investigator: Matteo Parotto, MD, PhD — UHN
- Study coordinator: Matteo Parotto, MD, PhD
- Email: matteo.parotto@uhn.ca
- Phone: +1 416 340 3567
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Extubation