Radiation treatment comparison for metastatic prostate cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This phase II trial investigates the side effects of two different radiation treatment schedules for patients with metastatic prostate cancer. Participants will receive radiation either every other day for two weeks or once weekly for six weeks. The study aims to determine if the frequency of treatment affects the side effects experienced by patients. It is a randomized trial, meaning participants will be assigned to one of the two treatment groups by chance.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Histologically-proven prostate cancer
* Presence of low-volume or high-volume metastases (high volume defined as the presence of visceral metastases or ≥4 bone lesions with at least 1 lesion beyond the vertebral bodies and pelvis.)
* Planned to or receiving systemic treatment ADT +/- ARAT as per physician discretion (Previous chemotherapy allowed if completed more than 6 weeks prior to randomization.)
* Planned for EBRT
* ECOG 0 or 1
* Age 18 years or older

Exclusion Criteria:

* Prior radiotherapy to pelvis
* Active ulcerative colitis or Crohn's Disease, at discretion of treating physician
* Any condition where radiotherapy is contraindicated

Where it's running

• University Health Network, Princess Margaret Hospital
  Toronto, Ontario, Canada Recruiting

Study contacts

• Study coordinator: Peter Chung, MD
• Email: peter.chung@rmp.uhn.ca
• Phone: 416-946-4501

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.