Improving lung transplant outcomes with inspiratory muscle training

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the feasibility and effectiveness of inspiratory muscle training (IMT) for lung transplant candidates. The study aims to assess how IMT can enhance respiratory muscle strength and potentially reduce post-operative complications after lung transplantation. Participants will engage in a structured exercise training program while undergoing outpatient pulmonary rehabilitation. The trial will evaluate recruitment rates, retention, adherence to the program, and changes in dyspnea perception and diaphragm function.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult participants (≥ 18 years of age)
* Lung Transplant Candidates
* Participating in outpatient pulmonary rehabilitation (standard of care)
* Diagnosis of Interstitial Lung Disease or Chronic Obstructive Pulmonary Disease

Exclusion Criteria:

* Respiratory exacerbation within the last 1 month
* Neurologic or musculoskeletal conditions that may interfere with IMT or functional assessments (i.e. history of stroke, severe arthritis of hands)
* Insufficient English fluency to provide informed consent or to follow study protocols
* Any evidence of pneumothorax on recent imaging (\< 6 months)
* Present ruptures of eardrums or infections leading to fluid behind ear drum
* Marked left or right ventricular end-diastolic volume and pressure overload on right heart catheterization or echocardiogram
* Severe osteoporosis with history of rib fractures
* Cardiac pacemaker or other electronic or magnetic body implant
* Individuals listed as rapidly deteriorating or inpatient at the time of eligibility assessment
* Individuals awaiting a re-transplant
* Inability of the patient to connect to the internet

Where it's running

• Edmonton Lung Transplant Program
  Edmonton, Alberta, Canada Recruiting
• Vancouver General Hospital
  Vancouver, British Columbia, Canada Recruiting
• University Health Network
  Toronto, Ontario, Canada Recruiting
• Centre hospitalier de l'Université de Montréal (CHUM)
  Montreal, Quebec, Canada Recruiting

Study contacts

• Principal investigator: Dmitry Rozenberg, MD, PhD — University Health Network/University of Toronto
• Study coordinator: Dmitry Rozenberg, MD, PhD
• Email: Dmitry.Rozenberg@uhn.ca
• Phone: 416-340-4800

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.