Evaluating Liquid Biopsy and Positron Emission Mammography for High-risk Breast Cancer Detection
Official title: Breast Cancer Combined Visualization And Characterization Tools - Novel Positron Emission Mammography System and Liquid Biopsy
Run by University Health Network, Toronto · NCT06268405 · Data updated 2026-11-12
This study is testing two new tests, a blood test and a special imaging scan, to see if they can help women at high risk for breast cancer find it earlier.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 100 (estimated) |
| Sponsor | University Health Network, Toronto Academic / other |
| Locations | 1 site (Toronto, Ontario) |
| Status | Recruiting |
| Started | September 21, 2023 |
| Main results expected | July 31, 2026 |
| Study ends | July 31, 2027 |
| Registry record updated | April 29, 2026 |
| Trial ID | NCT06268405 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are women over 18 years old who are scheduled for an MRI-guided biopsy due to high-risk screening imaging findings.
✕Probably not a fit
Patients without suspicious lesions detected by standard mammograms or MRIs will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This research evaluates the effectiveness of two innovative tests, Liquid Biopsy and Positron Emission Mammography (PEM), in women identified as high-risk for breast cancer. Participants will undergo a blood draw for the Liquid Biopsy and a PEM imaging exam to assess breast abnormalities. The study aims to determine if the results from these tests can enhance the ability of radiologists to visualize and characterize suspicious breast lesions, potentially leading to earlier detection of breast cancer. Following these tests, participants may also have an MRI-guided biopsy if necessary.
Why it matters
Potential benefit: If successful, this approach could lead to improved early detection of breast cancer in high-risk women.
How similar studies have gone: While the combination of Liquid Biopsy and PEM is a novel approach, similar studies have shown promise in enhancing cancer detection methods.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Individuals who are older than 18 years of age * Individuals who are planned to undergo an MRI-guided biopsy based on high- risk screening imaging detected lesions * Individuals with the ability to understand and the willingness to sign a written informed consent document Exclusion Criteria: * High-risk Individuals with screening-imaging studies without suspicious lesions detected by the standard of care mammogram and/or MRI * Individuals who are pregnant or who think they may be pregnant * Individuals who are breast-feeding * Individuals with known allergies to F-18 FDG
Where it's running
-
University Health Network
Toronto, Ontario, Canada Recruiting
Study contacts
- Principal investigator: Vivianne Freitas, MD — University Health Network, Toronto
- Study coordinator: Samira Taeb, MSc
- Email: samira.taeb2@uhn.ca
- Phone: 416-946-4501
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Gyrotonic exercise for elders with breast cancer and Behcet disease
We’re testing whether a gyrotonic exercise program helps older people who have both Behcet disease and breast cancer.
-
PECS II vs SPSIP nerve blocks for pain after mastectomy
This study tests whether two ultrasound-guided nerve blocks (PECS II and SPSIP) differ in how much opioid patients need after mastectomy.
-
CG-7321: a first-in-human test in advanced solid tumors
We’re testing CG-7321 alone and with fulvestrant to see if it’s safe and tolerable in adults with advanced solid tumors.
-
Compare a new endoscopy-assisted breast-conserving surgery with the usual approach
This study tests whether a new endoscopy-assisted breast-conserving technique can provide similar or better cosmetic outcomes and safety compared with conventional breast-conserving surgery in women with early breast cancer who want to preserve their breast.
-
Different skin care approaches to prevent skin reactions after mastectomy radiation
This study tests three standard skin care methods to see which best prevents radiation dermatitis in people who had a mastectomy and are receiving post-mastectomy radiation therapy.
-
3D Heart Strain to Detect Early Cardiotoxicity in Cancer Therapy
This study tests whether 3D echocardiography can detect early heart damage from cancer treatments like anthracyclines or HER2-targeted therapy better than standard 2D methods.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.