Using HyperSight imaging and Ethos adaptive planning during radiation therapy for children

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center prospective pilot will enroll 20 patients age 18 or under who are receiving at least five days of non-cranial radiation therapy. Participants will receive standard-of-care radiation with the addition of twice-weekly HyperSight cone-beam CT scans to document anatomical changes. The scans will be used to generate adapted plans on the Ethos platform, and radiation oncologists and therapists will independently judge the need for adaptation. Adapted plans will be compared to scheduled plans using dosimetric and anatomical similarity metrics, and an optional anonymized data-sharing sub-study with the vendor is offered.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient (paediatric or adolescent) age 18 or under receiving at least 5 days of radiation therapy
* Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 3

Exclusion Criteria:

\- Patients with primary cranial tumours will be excluded due to the low expected utility of non-contrast CT scans in the delineation of brain edema and brain substructures.

Where it's running

• Princess Margaret Cancer Centre
  Toronto, Ontario, Canada Recruiting

Study contacts

• Study coordinator: Dana Keilty, MD
• Email: dana.keilty@uhn.ca
• Phone: 416-946-4501

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.