Using HyperSight imaging and Ethos adaptive planning during radiation therapy for children
Hypersight and Ethos In Pediatric Radiotherapy (Peds Ethos)
This pilot will test whether adding twice-weekly HyperSight CBCT scans and Ethos adaptive planning can help tailor radiation treatment for children and teenagers with non-cranial cancers.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | N/A to 18 Years |
| Sex | All |
| Sponsor | University Health Network, Toronto Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Toronto, Ontario) |
| Trial ID | NCT07528547 on ClinicalTrials.gov |
What this trial studies
This single-center prospective pilot will enroll 20 patients age 18 or under who are receiving at least five days of non-cranial radiation therapy. Participants will receive standard-of-care radiation with the addition of twice-weekly HyperSight cone-beam CT scans to document anatomical changes. The scans will be used to generate adapted plans on the Ethos platform, and radiation oncologists and therapists will independently judge the need for adaptation. Adapted plans will be compared to scheduled plans using dosimetric and anatomical similarity metrics, and an optional anonymized data-sharing sub-study with the vendor is offered.
Who should consider this trial
Good fit: Children and adolescents (18 years old or younger) receiving at least five days of non-cranial radiation therapy with an ECOG performance status of 0–3 are ideal candidates.
Not a fit: Patients with primary cranial (brain) tumors are excluded and are unlikely to benefit because non-contrast CT scans have limited value for delineating brain substructures, and very short treatment courses may offer little opportunity for adaptation.
Why it matters
Potential benefit: If successful, this approach could improve how accurately radiation targets tumors while reducing dose to nearby healthy tissues in pediatric patients.
How similar studies have performed: Adaptive planning with frequent CBCT has shown promise in adult radiotherapy, but application in pediatric non-cranial cases is novel and not yet well established.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient (paediatric or adolescent) age 18 or under receiving at least 5 days of radiation therapy * Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 3 Exclusion Criteria: \- Patients with primary cranial tumours will be excluded due to the low expected utility of non-contrast CT scans in the delineation of brain edema and brain substructures.
Where this trial is running
Toronto, Ontario
- Princess Margaret Cancer Centre — Toronto, Ontario, Canada (Recruiting)
Study contacts
- Study coordinator: Dana Keilty, MD
- Email: dana.keilty@uhn.ca
- Phone: 416-946-4501
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.