Predicting disease progression in dementia using biomarkers and modeling

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to develop a predictive model for disease progression in patients with mild cognitive impairment and various forms of dementia, including Alzheimer's Disease and Lewy Body Disease. It will evaluate a range of assessments such as brain imaging, body fluid samples, and cognitive tests to gather comprehensive data. The goal is to utilize this information to enhance diagnostic accuracy and better forecast the progression of neurodegenerative diseases. By integrating multiple biomarkers and cognitive assessments, the study seeks to improve prognostic confidence in affected patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Possible or probable diagnosis of MCI or early dementia
* Age 30-95
* Study partner who has some weekly contact with patient. Some of the neuropsychological assessment require collateral from close contacts to assess cognition and functioning. Since neurodegenerative diseases can be associated with reduced cognition, including reduced awareness of one's own impairments, participants will be assessed for their capacity to consent at all study visits.
* Must, in the opinion of the site investigator, be able to complete most study procedures.

Exclusion Criteria:

* Participants who are not able to complete the majority of assessments in the opinion of the PI are excluded from the study. Exclusion criteria are evaluated at the site investigator's discretion; if the site investigator believes that the participant's symptoms are due to causes other than neurodegeneration, despite the presence of an exclusionary condition, the investigator may overrule the exclusion.

Where it's running

• Toronto Western Hospital, University Health Network
  Toronto, Ontario, Canada Recruiting
• Baycrest
  North York, Ontario, Canada Not yet recruiting
• Sunnybrook Health Sciences Centre
  Toronto, Ontario, Canada Not yet recruiting
• Centre for Addiction and Mental Health
  Toronto, Ontario, Canada Not yet recruiting

Study contacts

• Principal investigator: Maria C Tartaglia, M.D. — Toronto Western Hospital, UHN; Tanz CRND
• Study coordinator: Claudia Clementi, HBSc
• Email: claudia.clementi@uhn.ca
• Phone: 416-603-5914

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.