Lung transplants from A2 donors to O recipients
Official title: Blood Group A2 Donor to Blood Group O Recipient Lung Transplantation
Run by University Health Network, Toronto · NCT05581745 · Data updated 2026-11-12
This study is testing if lung transplants from A2 blood type donors can safely help people with O blood type who are waiting for a transplant.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 10 (estimated) |
| Sponsor | University Health Network, Toronto Academic / other |
| Locations | 1 site (Toronto, Ontario) |
| Status | Recruiting |
| Started | July 14, 2022 |
| Main results expected | December 31, 2027 |
| Study ends | December 31, 2033 |
| Registry record updated | September 29, 2026 |
| Trial ID | NCT05581745 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are first-time lung transplant recipients with blood group O and low pre-operative anti-A antibody titers.
✕Probably not a fit
Patients who may not benefit include those requiring re-transplants, multiorgan transplants, or those with a positive virtual crossmatch at the time of transplant.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the feasibility and safety of lung transplants from blood group A2 donors to blood group O recipients. It aims to address the longer wait times and higher mortality rates faced by blood group O candidates by expanding the donor pool. The study will involve a prospective approach, assessing the outcomes of these ABO-incompatible transplants while utilizing peri-operative antibody-depleting therapies. This is the first prospective study of its kind worldwide, focusing on improving transplant accessibility for blood group O patients.
Why it matters
Potential benefit: If successful, this approach could significantly reduce wait times and improve survival rates for blood group O lung transplant candidates.
How similar studies have gone: Other studies have shown success with ABO-incompatible kidney and liver transplants, but this approach for lung transplants is novel and untested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * first lung transplant * blood group O recipient * low pre-operative anti-A antibody titers * consent to study participation Exclusion Criteria: * re-transplant * multiorgan transplant * positive virtual crossmatch at time of transplant
Where it's running
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Toronto General Hospital, University Health Network
Toronto, Ontario, Canada Recruiting
Study contacts
- Principal investigator: Shaf Keshavjee, MD MSc FRCSC FACS — University Health Network, Toronto
- Study coordinator: Sharaniyaa Balachandran
- Email: sharaniyaa.balachandran@uhn.ca
- Phone: 416-340-4800
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Research on improving outcomes for lung transplant donors and recipients
This study is trying to see how different donor and medical practices affect the health of lung transplant patients and donors, while also looking for blood markers that might predict complications after the surgery.
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Multidisciplinary non-drug program to improve quality of life after solid organ transplant
A multidisciplinary, non-drug program using acupuncture, remote physical rehab, and brain-health activities is being tested to see if it can improve quality of life for adults at least one year after heart, kidney, liver, or lung transplant.
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Multimodal prospective approach to understand acute and chronic lung transplant rejection
This project will see if blood tests, airway sampling, imaging, and genetic analyses can identify which adults who have had or are being evaluated for a lung transplant will develop antibody‑mediated rejection and later chronic graft dysfunction.
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Airway response to exercise after double lung transplant
This study will see if short (5-minute) versus longer (15-minute) constant-work exercise causes different airway narrowing and breathlessness in people who have had a double lung transplant.
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Measuring breathing effort before and after removing the breathing tube
This will test a new electrical impedance method to measure breathing effort in adults on ventilators as they try breathing on their own and after the breathing tube is removed.
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Cryo nerve block to improve recovery after bilateral lung transplant
This pilot will test whether adding a cryo nerve block around the chest helps people with end-stage COPD recover better after a bilateral lung transplant.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.