Comparing two types of radiation therapy for spinal cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to compare the effectiveness of stereotactic body radiation therapy (SBRT) versus conventional radiation therapy (CRT) in patients with spinal metastases. Researchers will gather data on radiation oncologists' decision-making processes through questionnaires and analyze real-world outcomes such as local progression, pain response, and overall survival rates. The goal is to develop an evidence-based algorithm to aid future medical decisions for patients with similar conditions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults 18 years of age or older.
* Patients seen at the Princess Margaret Cancer Centre with painful spinal metastases amenable to radiation treatment.
* Confirmation of diagnosis: a) Known/documented prior histological cancer diagnosis
* Able to provide written consent
* ECOG performance status 0-3

Exclusion Criteria:

* Prior radiotherapy, with fields overlapping, resulting in excessive doses to organs at risk
* Lymphoma, myeloma or germ cell malignancies

Where it's running

• University Health Network
  Toronto, Ontario, Canada Recruiting

Study contacts

• Study coordinator: David Shultz, MD
• Email: david.shultz@rmp.uhn.ca
• Phone: 416-946-4501

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Stereotactic body radiation therapy for spinal metastases with epidural compression

  This study tests whether SBRT can safely help adults with spinal metastases that compress the spinal cord see if the treatment works in reducing issues from their cancer.

  Recruiting Tianjin Medical University Cancer Institute and Hospital · Tianjin · NCT07809672

• Postoperative Edge SBRT for Spinal Metastases

  This observational study tests whether high-precision postoperative SBRT with the Edge system can improve local control and neurological outcomes in patients with spinal metastases after surgery.

  Recruiting Tianjin Medical University Cancer Institute and Hospital · Tianjin, Tianjin Municipality · NCT07801274

• Radiotherapy after Separation Surgery for Spinal Metastases

  This study tests whether giving radiotherapy after separation surgery helps people with spinal metastases live longer and feel better.

  Recruiting Shanghai Changzheng Hospital · Shanghai, Shanghai Municipality · NCT07527884

• Focused high-dose SBRT for spinal tumors

  This program will try focused high-dose SBRT for adults with spinal metastases to track side effects and local tumor control during routine care.

  Recruiting at 2 sites Institute of Oncology Ljubljana · Ljubljana and 1 other locations · NCT07429422

• Pre-surgery focused radiation for spinal metastases.

  This trial will test whether short-course, focused radiation given before surgery can improve local tumor control and reduce pain and disability in adults with spinal metastases.

  Recruiting University Medical Center Goettingen · Göttingen · NCT07135817

• Evaluating autologous blood transfusion in spinal surgery for lung cancer with spinal metastasis

  This study is testing whether using a patient's own blood during spinal surgery for lung cancer with spinal metastases is safer and more effective than using donated blood.

  Recruiting Guangdong Provincial People's Hospital · Guangzhou, Guangdong · NCT06244264

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.