Rehabilitation program for allogeneic bone marrow transplant patients
A Type 1 Hybrid Effectiveness Implementation Trial of a Longitudinal Multidimensional Rehabilitation Program for Patients Undergoing Allogeneic Blood and Marrow Transplantation (CaRE4alloBMT)
NA · University Health Network, Toronto · NCT07457866
This trial will test whether the CaRE-4-alloBMT rehab program helps adults having allogeneic bone marrow transplants recover better than usual care.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 208 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Health Network, Toronto (other) |
| Locations | 1 site (Toronto, Ontario) |
| Trial ID | NCT07457866 on ClinicalTrials.gov |
What this trial studies
This is a pragmatic, two-arm randomized controlled trial comparing the CaRE-4-alloBMT rehabilitation program to usual care in adults undergoing allogeneic bone marrow transplant. Participants complete questionnaires and an initial assessment with a registered kinesiologist, then are randomized to the intervention or usual care. Outcomes include patient-reported measures and physiological assessments collected at baseline, hospital admission, discharge, and at 3 and 6 months post-discharge to capture real-world recovery. The trial emphasizes external validity to inform whether the program can be delivered in routine clinical practice.
Who should consider this trial
Good fit: Adults (age >18) scheduled for allogeneic bone marrow transplant for a hematologic cancer who complete pre- and post-transplant care at Princess Margaret Cancer Centre, can access online study material, and understand English.
Not a fit: Patients who have comorbidities or musculoskeletal issues that preclude exercise, cannot access online materials, are being admitted for transplant within two weeks of assessment, or are enrolled in other interventional studies may not benefit from this program.
Why it matters
Potential benefit: If successful, the program could speed physical recovery, improve quality of life, and reduce post-transplant complications for alloBMT patients.
How similar studies have performed: Exercise and prehabilitation programs in cancer populations have shown benefits for physical function and recovery, but robust phase‑III evidence specifically for allogeneic BMT patients is still limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: • scheduled to undergo alloBMT and are: * \> 18 years of age; * receiving treatment for a hematologic cancer; * completing pre- and post-transplant care at PM; * able to access on-line study material; and * able to understand (spoken and written) English. Participants receiving a second transplant at the time of screening will be included if they meet the above criteria. Exclusion Criteria: * scheduled to be admitted to the hospital for their alloBMT \< 2 weeks from the initial assessment booking, as this will not allow enough time for the prehabilitation phase of the study; * are participating in any other clinical trials or supportive care intervention studies; or * have comorbidities or musculoskeletal complications that preclude participation in the exercise programs.
Where this trial is running
Toronto, Ontario
- Princess Margaret Cancer Centre — Toronto, Ontario, Canada (RECRUITING)
Study contacts
- Principal investigator: Jennifer M Jones, PhD — UHN Princess Margaret Cancer Centre
- Study coordinator: Jennifer M Jones, PhD
- Email: Jennifer.jones@uhn.ca
- Phone: 14165818603
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Allogenic Bone Marrow Transplantation, allogenic bone marrow, rehabilitation, cancer