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Clinical trials and research at The Cleveland Clinic

• 127Clinical trials
• 15Countries

Newest trials

All recruiting trials (127)

• Choose Myself (Before) Losing Myself

  We’re testing an educational interactive booklet to help people with dementia or memory problems think about future medical decisions and start conversations with family or caregivers.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07846566

• Endurance exercise to see if it lowers alcohol use in adults with AUD and ALD

  A 12-week home-based cycling program added to standard care is tested to see if it reduces alcohol use and cravings in adults with alcohol use disorder and alcohol-related liver disease.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07824089

• Robotic adrenalectomy with imaging to guide dissection using a dye

  A randomized comparison tests whether adding indocyanine green (ICG) imaging during robotic adrenalectomy helps surgeons find the adrenal gland and perform the operation.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07813247

• NIRAF imaging to help parathyroid removal when preoperative tests don’t locate glands

  This trial tests whether using an NIRAF camera during parathyroid surgery helps find and remove abnormal glands in people with primary hyperparathyroidism when prior imaging hasn’t pinpointed them.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07812649

• 4D intracardiac echocardiography to guide left atrial appendage occlusion procedures

  A new 4D ICE catheter is being tested alongside standard imaging to see if it can safely guide left atrial appendage occlusion procedures for adults with atrial fibrillation.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07806890

• Noninvasive imaging biomarkers to see if ophthalmic artery narrowing relates to geographic atrophy in age-related macular degeneration

  This study tests whether narrowed ophthalmic artery vessels are linked to the development or worsening of geographic atrophy in people with dry age-related macular degeneration.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07798323

• Non-invasive brain stimulation to see if it changes pain avoidance in CRPS

  This study tests whether a gentle brain stimulation method called tACS can change how people with complex regional pain syndrome avoid activities that might worsen their pain.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07791966

• Decoding brain signals and DBS settings for freezing of gait in Parkinson’s

  This study tests how brain activity and different DBS settings affect freezing of gait and balance in people with Parkinson’s who already have a Medtronic Percept DBS device.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07748962

• Imaging changes in muscle with semaglutide for type 2 diabetes and obesity

  This study follows adults with type 2 diabetes and obesity who are starting semaglutide to see how their muscle size, strength, and metabolism change over 6 months using MRI and 31P-MRS imaging.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07695454

• Smell training in CRS patients with smell loss

  This study tests whether a 3-month smell training program can improve smell function and related immune and mental health measures in adults with chronic rhinosinusitis and smell loss.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07681973

• Ultrasound-guided margin choice during ileocolic resection for Crohn's disease

  This trial tests whether using ultrasound to guide how much tissue to remove during ileocolic surgery for terminal ileal Crohn's disease helps people see better outcomes than using the usual surgeon-determined margins.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07680283

• Self-Start Macrobid for post-Botox lower urinary symptoms

  This study tests whether giving a standing prescription for Macrobid after Botox treatment reduces urgent calls, messages, and visits for urinary symptoms compared with usual triage care.

  Recruiting Early Phase 1 The Cleveland Clinic · Cleveland, Ohio · NCT07648290

• At-home bowel stimulation before ileostomy closure

  This study tests whether people with a protective loop ileostomy can do daily at-home bowel stimulation for three weeks before closure to lower their chance of postoperative ileus.

  Recruiting The Cleveland Clinic · Weston, Florida · NCT07574437

• Low-cost HPV test that gives same-day results and treatment in women 30-59

  A low-cost HPV test done on the same day as a self-collected sample is being tested to see if it can reliably screen for cervical cancer and enable immediate treatment in women aged 30-59 in San Salvador.

  Recruiting The Cleveland Clinic · San Salvador, Oriente · NCT07538050

• Teaching adults with epilepsy how social factors affect surgery access and outcomes

  This project will test whether giving adults with epilepsy extra education about social factors that affect care increases access to epilepsy surgery and improves outcomes.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07509190

• Using a virtual reality headset during endoscopy to improve operator comfort

  This study will try the Apple Vision Pro headset during colonoscopy, EUS, and ERCP to see if it makes the endoscopist more comfortable and is practical to use during procedures.

  Recruiting The Cleveland Clinic · Weston, Florida · NCT07493863

• Centered Surgery: Preoperative Counseling to Improve Patient Satisfaction

  This study will test whether virtual group counseling sessions (shared medical appointments) help adults having pelvic organ prolapse surgery feel more satisfied and better prepared compared with standard individual phone calls.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07471464

• Ren-Nu: a kidney-focused ketogenic diet program for people with polycystic kidney disease

  This 16-week pilot will try a dietitian-led, kidney-safe ketogenic program plus KetoCitra in adults with ADPKD to improve metabolic health.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07454174

• How aerobic exercise (forced vs voluntary cycling) affects movement, thinking, and brain signals in people with Parkinson’s and deep brain stimulation

  This study tests whether forced or voluntary cycling improves movement, thinking, and brain activity in people with Parkinson’s who already have a DBS device.

  Recruiting Phase 2 The Cleveland Clinic · Cleveland, Ohio · NCT07442747

• Parent-led sleep program for insomnia in young autistic children

  This trial tests whether a parent-delivered Sleep Parent Treatment (SPT) helps improve sleep for autistic kids aged 3 to almost 8 years, compared with Sleep Parent Education (SPE), over 10 weeks.

  Recruiting at 3 sites The Cleveland Clinic · Cleveland, Ohio and 2 other locations · NCT07435740

• Long-term follow-up of MRI markers (central vein sign and paramagnetic rim lesions) in multiple sclerosis

  This project will test whether two MRI markers—the central vein sign (CVS) and paramagnetic rim lesions (PRL)—help diagnose and track people with multiple sclerosis over 48 months.

  Recruiting The Cleveland Clinic · Los Angeles, California and 2 other locations · NCT07424027

• Continuous glucose monitoring in PCOS

  This study tests how blood sugar changes over time in adults with PCOS using a continuous glucose monitor.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07392476

• Nifedipine and Enalapril vs Nifedipine and Labetalol for Postpartum Hypertension

  This study tests whether adding enalapril to nifedipine better controls postpartum hypertension than adding labetalol.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07363343

• Antiseptic-coated sutures to reduce pancreatic fistula risk after Whipple

  This trial tests whether using antiseptic-coated sutures during a Whipple procedure reduces the chance of developing a pancreatic fistula within 90 days after surgery.

  Recruiting at 3 sites The Cleveland Clinic · Akron, Ohio and 2 other locations · NCT07318493

• Using FMN levels in perfusate and bile to check liver graft health during warm machine perfusion

  This project will test whether measuring flavin mononucleotide (FMN) in perfusate and bile during normothermic machine perfusion can help identify which adult deceased-donor livers are safe to transplant.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07315204

• Intensive hypertension management program at Cleveland Clinic

  This program will try team-based medication adjustments guided by home blood pressure readings to lower very high blood pressure in adults (18–85) with hypertension and readings over 150/95.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07232017

• Methadone to reduce long-term opioid use after major spine surgery

  This pilot trial will test whether a short course of postoperative oral methadone can help adults having multilevel lumbar or thoracic spine fusion use fewer opioids three months after surgery.

  Recruiting Phase 4 The Cleveland Clinic · Cleveland, Ohio · NCT07222072

• Pre-surgery BOTOX to help close very large ventral hernias

  This test tries a one-time image-guided BOTOX injection into the side abdominal muscles 3–7 weeks before open repair to see if it helps surgeons fully close very large ventral hernias in adults.

  Recruiting Phase 4 The Cleveland Clinic · Cleveland, Ohio · NCT07220382

• Treating elevated blood pressure during hospital stays to see if it changes outcomes

  We are testing whether changing how hospitals respond to briefly high blood pressure in adults on general medical units reduces unnecessary increases in blood-pressure medicines and improves patient outcomes.

  Recruiting at 2 sites The Cleveland Clinic · Cleveland, Ohio and 1 other locations · NCT07208669

• Imaging to track ARPKD kidney disease progression

  This project will test whether quick, quantitative non-contrast MRI scans can reliably track kidney disease progression in people aged 6 and older with ARPKD compared with healthy controls.

  Recruiting at 2 sites The Cleveland Clinic · Cleveland, Ohio and 1 other locations · NCT07201025

• Thulio versus Holmium lasers for removing enlarged prostate tissue

  This trial will test whether the new pulsed Thulio (thulium) laser works as well as the standard holmium laser for men with enlarged prostates and urinary symptoms.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07187180

• Nurse-led daily weight tracking to improve heart failure self-care and quality of life

  This pilot will try a simple nurse-led 'Wake and Weigh' weight tracking tool to see if it helps adults 55 and older with heart failure improve self-care and quality of life.

  Recruiting The Cleveland Clinic · Avon, Ohio · NCT07184541

• BOOST-PD: Crexont (IPX203) to lengthen and improve 'good on' time in Parkinson's

  This study will see if switching to IPX203 (Crexont), a longer‑acting levodopa formulation, can increase and improve periods of 'good on' time for people with Parkinson's who still have at least two hours of off time each day.

  Recruiting Phase 4 The Cleveland Clinic · Cleveland, Ohio · NCT07138560

• How GLP-1 and GIP medications affect colonoscopy bowel cleansing

  This test will see if taking GLP‑1 or GIP medications affects bowel cleansing for adults getting an outpatient colonoscopy.

  Recruiting at 3 sites Phase 4 The Cleveland Clinic · Cleveland, Florida and 2 other locations · NCT07127354

• Apple Watch vs Zio Patch for tracking AF burden after mitral valve surgery

  This project will test whether the Apple Watch AFib History tool can track atrial fibrillation burden as accurately as the Zio Patch in adults who have had mitral valve surgery with a Cox‑Maze IV ablation.

  Recruiting at 2 sites The Cleveland Clinic · St Louis, Missouri and 1 other locations · NCT07122947

• Nighttime recordings of brain signals while changing deep brain stimulation in Parkinson's disease

  This project tests whether changing nighttime deep brain stimulation settings and recording brain signals during sleep can help understand and improve sleep in people with Parkinson's disease who have a Medtronic Percept PC implant.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07110376

• Amniotic (placental) tissue to protect the bile-duct connection after living-donor liver transplant

  This trial will try placing a placental (amniotic) tissue graft around the bile-duct connection to see if it lowers complications in adults getting a living-donor liver transplant.

  Recruiting Phase 2 The Cleveland Clinic · Cleveland, Ohio · NCT07102550

• CPAP for sleep apnea–triggered atrial fibrillation

  This pilot tests whether alternating periods with and without CPAP can cut down AF episodes and improve AF-related quality of life for people with paroxysmal AF and moderate to severe obstructive sleep apnea.

  Recruiting The Cleveland Clinic · Cleveland, Ohio and 1 other locations · NCT07087587

• Longitudinal Assessment of Cardiac MRI Microstructure in Patients and Healthy People

  This study tests advanced, non-contrast and extended clinical cardiac MRI techniques to see how heart tissue features differ between people with heart disease and healthy individuals.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07081711

• Virtual groups to reduce sarcoidosis-related fatigue

  This project tests whether an 8-week virtual Mindfulness-Based Stress Reduction (MBSR) program can help reduce fatigue and improve anxiety and depression in adults with sarcoidosis compared with a monthly virtual support group.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07073963

• Multidisciplinary sarcopenia clinic to diagnose and treat muscle loss from COPD

  This project will try a multidisciplinary sarcopenia clinic to see if it improves muscle mass, function, and overall health for COPD patients with CT-confirmed muscle loss after a hospitalization.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07059637

• Using TIPS before sleeve gastrectomy to improve outcomes for people with cirrhosis and severe obesity

  This trial tests whether placing a TIPS (a portal decompression procedure) before sleeve gastrectomy helps adults with cirrhosis, clinically significant portal hypertension, and severe obesity lose weight, feel better, and have fewer complications.

  Recruiting Phase 4 The Cleveland Clinic · Cleveland, Ohio · NCT07058155

• Deep cerebellar nucleus stimulation for refractory tremor

  This study will try deep brain stimulation of the deep cerebellar nuclei with the Medtronic Percept RC device to reduce tremor in adults whose essential tremor, cerebellar outflow tremor, or MS-related tremor did not improve with or are not suitable for thalamic DBS or focused ultrasound.

  Recruiting Phase 1 The Cleveland Clinic · Cleveland, Ohio · NCT07049003

• Transperineal laser ablation to treat persistent obstruction from BPH after minimally invasive procedures

  This test will try in-office transperineal laser ablation (TPLA) to relieve urinary blockage and symptoms in men whose BPH returned after prior minimally invasive treatments.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07016620

• Empagliflozin to Help the Right Side of the Heart in PAH

  This trial tests whether taking empagliflozin daily for 6 months helps right heart function in adults with pulmonary arterial hypertension who are already on approved PAH medicines.

  Recruiting at 3 sites Phase 2 The Cleveland Clinic · Baltimore, Maryland and 2 other locations · NCT06992440

• Comparing two types of sutures for closing groin incisions after vascular surgery

  This study is testing whether using Vicryl or PDS sutures helps reduce complications after groin surgery for patients over 18.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT06990425

• Rotator cuff repair with ActivBraid collagen co-braid suture

  We will test whether using the ActivBraid collagen co-braid suture during primary arthroscopic rotator cuff repair in adults improves tendon healing, shoulder motion, strength, and patient-reported outcomes over 6 months to 2 years.

  Recruiting at 2 sites The Cleveland Clinic · Cleveland, Ohio and 1 other locations · NCT06971497

• Surgeon-administered Exparel for pain control during total knee replacement

  This study will test whether a surgeon‑administered Exparel IPSA block with local infiltration provides similar or better pain relief than an anesthesiologist‑administered adductor canal block for adults having a primary unilateral total knee replacement.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT06946368

• Comparing cold and hybrid techniques for removing large colon polyps

  This study is testing if a new way of removing large colon polyps that combines two techniques can lower the chances of the polyps coming back and reduce complications for adults with certain types of polyps.

  Recruiting at 2 sites The Cleveland Clinic · Weston, Florida and 1 other locations · NCT06937671

• Pulsed field ablation versus radiofrequency for ventricular tachycardia after a heart attack

  This trial will test whether pulsed field ablation (FARAPOINT) can treat ventricular tachycardia after a heart attack more efficiently and with similar safety compared with standard radiofrequency ablation in people with ischemic cardiomyopathy.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT06891456

• Managing necrotizing soft tissue infections with specialized wound matrices

  This study is testing if special wound dressings can help people with severe skin infections heal better than regular dressings.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT06857708

• Topical ruxolitinib cream to treat stubborn skin symptoms of dermatomyositis

  This will test whether applying 1.5% ruxolitinib cream helps adults with dermatomyositis whose skin symptoms have not improved with other treatments.

  Recruiting Phase 2 The Cleveland Clinic · Cleveland, Ohio · NCT06857240

• Assessing heart failure management and social factors

  This study looks at how social factors affect heart failure diagnoses and treatment to help improve care for people newly diagnosed with heart failure.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT06849752

• Monitoring pregnant women with congenital heart disease using wrist wearables

  This study is testing whether using wrist wearables to monitor the health of pregnant women with congenital heart disease can help track their condition and improve their care.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT06818760

• Using Tirzepatide to treat obesity in patients with Atrial Fibrillation

  This study is testing if the weight loss medication Tirzepatide can help people with obesity and Atrial Fibrillation feel better and manage their symptoms.

  Recruiting Phase 2 The Cleveland Clinic · Cleveland, Ohio · NCT06802081

• Measuring heart microvascular function in heart attack patients

  This study is testing how well the tiny blood vessels in the heart work in people who have had a heart attack to see how treatment affects their recovery.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT06795035

• Understanding exercise effects on aortic aneurysm patients

  This study is testing how exercise affects people with aortic aneurysms to help find safe activity levels that could improve their health.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT06789809

• Identifying sex-specific biological markers in valvular heart disease

  This study is testing if special heart scans can help find different biological markers for men and women with aortic valve disease to improve treatment and recovery after surgery.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT06780241

• Comparing Botox and surgery for stomach drainage during esophagectomy

  This study is testing whether Botox injections can help people who have had esophagus surgery manage delayed stomach emptying just as well as surgery can.

  Recruiting Phase 2/3 The Cleveland Clinic · Cleveland, Ohio · NCT06721520

• Early versus standard timing of vasopressin for adults with septic shock

  This pilot tests whether starting vasopressin earlier versus at the usual time helps adults with septic shock who are receiving norepinephrine.

  Recruiting Phase 4 The Cleveland Clinic · Cleveland, Ohio · NCT06709573

• Monocyte responses in adults with type 1 diabetes and chronic kidney disease

  This study will test whether time-in-range changes how monocytes become activated in adults with type 1 diabetes and chronic kidney disease and whether a GLP-1 drug can reduce that activation in lab tests.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT06694558

• Using tranexamic acid to reduce bleeding in major colorectal surgery

  This study is testing if giving tranexamic acid before major colorectal surgery can help reduce bleeding during and after the operation for patients.

  Recruiting Phase 2 The Cleveland Clinic · Cleveland, Ohio · NCT06657924

• Intensive cycling exercise for stroke recovery

  This study is testing whether using a special cycling machine can help stroke survivors recover better during their outpatient rehab compared to regular therapy.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT06585943

• Collection of biospecimens for cardiovascular and metabolic research

  This study is collecting blood, urine, stool, and heart tissue samples from people with and without heart and metabolic diseases to help researchers learn more about these conditions and improve treatments.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT06560424

• Exploring how genetics and exercise can slow Parkinson's disease progression

  This study is testing if high-intensity cycling can help slow down Parkinson's disease for people based on their genetics.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT06442033

• Comparing robotic and laparoscopic sleeve gastrectomy for obesity treatment

  This study is testing whether robotic sleeve gastrectomy works better than laparoscopic sleeve gastrectomy for people with obesity in terms of pain, recovery, and quality of life after surgery.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT06425016

• Comparing two types of nerve blocks for pain management in upper abdominal surgery

  This study is testing which of two types of nerve blocks can help reduce pain better for people recovering from open upper abdominal surgery.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT06409156

• Comparing laparoscopic and robotic adrenal surgery

  This study is testing whether laparoscopic or robotic surgery works better for removing adrenal tumors to help improve patient care and surgical practices.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT06407024

• Improving prenatal genetic testing decisions for better outcomes

  This study is testing a new AI tool to help pregnant patients and their partners make better decisions about genetic testing during their pregnancy.

  Recruiting The Cleveland Clinic · Cleveland, Ohio and 2 other locations · NCT06382636

• Evaluation of the Triathlon Hinge Knee System outcomes

  This study is testing how well the Triathlon Hinge Knee System works for people getting knee surgeries, looking at their recovery and safety over time.

  Recruiting at 2 sites The Cleveland Clinic · Weston, Florida and 1 other locations · NCT06379321

• Improving liver health through metabolic surgery or medication

  This study is testing whether metabolic surgery or medication can improve liver health in people with liver disease and obesity.

  Recruiting at 2 sites Phase 4 The Cleveland Clinic · Phoenix, Arizona and 21 other locations · NCT06374875

• Non-narcotic pain control after elbow tenotomy

  This study is testing whether taking acetaminophen, diclofenac, or tramadol can help people manage pain after a specific elbow procedure while reducing the need for stronger narcotics.

  Recruiting at 2 sites Phase 4 The Cleveland Clinic · Coral Springs, Florida and 1 other locations · NCT06373978

• Detecting cortisol secretion issues in patients with adrenal incidentalomas

  This study is trying to see how common mild cortisol secretion problems are in people with adrenal incidentalomas and which tests work best to find them.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT06344143

• Using electrical stimulation during surgery to improve facial nerve graft outcomes

  This study is testing if using electrical stimulation during surgery can help improve nerve healing and smiles for people getting surgery for facial paralysis.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT06335719

• Personalized approach to improve satisfaction after knee surgery

  This study is testing if using a personalized tool that includes mental health and physical therapy support can help people feel more satisfied after knee surgery compared to standard care alone.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT06298721

• Comparing different limb lengths in gastric bypass surgery for weight loss

  This study is testing if adjusting the lengths of parts of gastric bypass surgery can help morbidly obese patients lose more weight and improve health issues like diabetes and high blood pressure compared to standard surgery.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT06293703

• Examining brain changes in patients with essential tremor receiving deep brain stimulation

  This study is testing how deep brain stimulation affects brain activity in people with essential tremor to find better ways to manage their symptoms.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT06293638

• Comparing sugammadex and neostigmine for reversing muscle relaxation during outpatient ERCP

  This study is testing whether sugammadex or neostigmine works better to reverse muscle relaxation in adults undergoing a specific outpatient procedure called ERCP.

  Recruiting Phase 3 The Cleveland Clinic · Cleveland, Ohio · NCT06136585

• Comparing two methods for weight loss after gastric bypass

  This study is testing two different ways to help people who have gained weight after gastric bypass surgery lose weight again, to see which method works better and is safer.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT06131281

• Healthy aging education for people with epilepsy who are 55 and older

  This trial tests whether a 12-week educational program about healthy aging, dementia risk factors, and chronic disease management can improve dementia knowledge and quality of life for older adults with epilepsy.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT06052605

• Evaluating glucose metrics in diabetes patients with and without gastroparesis

  This study is testing how glucose levels change in people with diabetes who have gastroparesis compared to those who don’t, using a continuous glucose monitor to help spot early signs of gastroparesis.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT06046833

• Personalized deep brain stimulation for Parkinson's disease

  This study is testing a new personalized deep brain stimulation approach for people with Parkinson's disease to see if it can better manage their motor symptoms by adjusting to their brain activity in real-time.

  Recruiting Phase 4 The Cleveland Clinic · Cleveland, Ohio · NCT06013956

• Using Intracardiac Echocardiography for Watchman Device Implantation

  This study is testing if using a special ultrasound method called Intracardiac Echocardiography can make it safer and easier to implant the Watchman device for patients with atrial fibrillation and a high risk of stroke.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT06007872

• Comparing two methods for kidney stone surgery

  This study is testing two different ways to perform kidney stone surgery to see which method works better for patients.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT05993546

• Training program to prepare patients for epilepsy surgery

  This study is testing a new training program for people with epilepsy to see if it helps them feel better and have a smoother experience before and after surgery compared to standard care.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT05992402

• Effects of exercise on patients with cirrhosis

  This study tests if a 12-week exercise program can help people with cirrhosis gain muscle and feel healthier.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT05982769

• Comparing mesh and sutures for paraesophageal hernia repair

  This study is testing whether using a special mesh or stitches works better to prevent paraesophageal hernias from coming back after surgery for people who need this repair.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT05974722

• Personalized risk prediction for functional mitral regurgitation using cardiac imaging

  This study is testing if advanced heart imaging can help predict how well patients with functional mitral regurgitation will respond to treatment.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT05965258

• Weight loss before surgery for abdominal wall hernia repair

  This study is testing if a weight loss program before surgery can help people with obesity have better results after abdominal wall hernia repair compared to those who have surgery right away.

  Recruiting at 2 sites The Cleveland Clinic · Chicago, Illinois and 1 other locations · NCT05925959

• Comparing low-intensity shockwave and radial wave treatments for erectile dysfunction and pelvic pain

  This study is testing whether focused shockwave therapy or radial wave therapy can help men with erectile dysfunction and people with chronic pelvic pain feel better.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT05868668

• Comparing two ways of taking acid-blocking medications for stomach ulcers after gastric bypass surgery

  This study is testing whether taking acid-blocking medication for stomach ulcers in an open capsule form works better than taking it in a whole capsule for people who have had gastric bypass surgery.

  Recruiting Phase 4 The Cleveland Clinic · Cleveland, Ohio · NCT05799105

• Improving mobility for older hospitalized patients

  This study tests if having mobility technicians help older hospitalized patients walk more often can improve their movement when they leave the hospital.

  Recruiting at 4 sites The Cleveland Clinic · Springfield, Massachusetts and 4 other locations · NCT05725928

• Development of advanced MRI techniques for heart disease assessment

  This study is testing new MRI techniques to see how heart tissue differs between people with heart disease and healthy individuals to improve heart assessments.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT05654272

• Examining heart changes in patients undergoing rehabilitation or bariatric surgery

  This study is testing how heart changes in people improve after they go through rehabilitation or weight-loss surgery to see if these changes can help spot heart problems early.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT05650307

• Evaluating blood platelets and biomarkers in healthy individuals

  This study is testing how blood platelets work in healthy people to see if it can help us understand their role in blood vessel problems and find new treatment options.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT05628974

• Biorepository for cardiovascular and metabolic disease research

  This study is collecting blood, urine, and stool samples from people with heart and metabolic diseases to help researchers better understand these conditions and improve care.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT05628948

• Comparing suture and mesh methods for repairing incisional hernias

  This study is testing whether using stitches instead of mesh for fixing incisional hernias helps people feel just as good one year after surgery.

  Recruiting at 4 sites The Cleveland Clinic · Gainesville, Florida and 4 other locations · NCT05599750

• Global Cardio Oncology Registry

  This study is collecting health information from cancer patients around the world to see what factors might increase their risk of heart problems caused by cancer treatments.

  Recruiting The Cleveland Clinic · Weston, Florida · NCT05598879

• Comparing mesh removal to no mesh removal for chronic groin pain after hernia repair

  This study is testing whether taking out hernia mesh helps people with chronic groin pain feel better compared to not removing the mesh after their hernia repair.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT05484635

• Comparing robotic and open methods for ventral hernia repair

  This study is testing if robotic surgery for ventral hernia repair can help patients leave the hospital a day earlier compared to traditional open surgery.

  Recruiting at 5 sites The Cleveland Clinic · Gainesville, Florida and 4 other locations · NCT05472987

• Using pyridostigmine to treat postoperative ileus after colorectal surgery

  This study is testing if a medication called pyridostigmine can help people who have bloating and no bowel movements after colorectal surgery feel better.

  Recruiting Phase 2/3 The Cleveland Clinic · Cleveland, Ohio · NCT05334485

• Using HMB and amino acids to improve muscle loss in cirrhosis

  This study is testing if a combination of HMB and amino acids can help people with cirrhosis build muscle and improve their health.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT05166499

• Evaluating the effects of HA35 on gut permeability and muscle response to alcohol

  This study is testing if a treatment called HA35 can improve gut health and how muscles respond to alcohol in healthy people.

  Recruiting Early Phase 1 The Cleveland Clinic · Cleveland, Ohio · NCT05025865

• Treatment for Moderate Alcoholic Hepatitis

  This study is testing a new treatment called HA35 to see if it helps people with moderate alcoholic hepatitis feel better compared to a placebo.

  Recruiting Early Phase 1 The Cleveland Clinic · Cleveland, Ohio · NCT05018481

• Bone marrow concentrate vs steroid shot for hip osteoarthritis

  In people with hip osteoarthritis, researchers test whether a bone marrow aspirate concentrate injection works differently from a Triamcinolone steroid injection to relieve pain and improve function.

  Recruiting Phase 3 The Cleveland Clinic · Weston, Florida · NCT04990128

• HMB supplementation for patients with alcoholic liver disease and COVID-19

  This study is testing if HMB supplements can help people with alcoholic liver disease who also have COVID-19 feel better and recover more effectively.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT04858412

• Ketamine treatment for young people who have attempted suicide

  This study is testing if ketamine can quickly help young people aged 14-30 who have recently tried to take their own lives feel less suicidal while they are in psychiatric care.

  Recruiting Phase 3 The Cleveland Clinic · Cleveland, Ohio · NCT04763343

• New technique for repairing thoracic aortic conditions

  This study is testing a new method to repair certain serious aortic conditions in patients by using a special type of stent to see if it is safe and effective.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT04747626

• Accelerated MRI techniques for assessing cartilage health

  This study is testing new, faster MRI methods to see if they can help people at risk for osteoarthritis by checking the health of their cartilage more accurately.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT04536103

• Comparing two types of anesthesia for esophageal cancer surgery

  This study is testing whether a new type of anesthesia can help people with esophageal cancer have better recovery and fewer chances of their cancer coming back after surgery.

  Recruiting Phase 3 The Cleveland Clinic · Shanghai · NCT04513808

• Using a dexamethasone insert to manage pain and inflammation after vitreoretinal surgery

  This study tests if a new dexamethasone insert can better manage pain and inflammation after eye surgery compared to regular steroid eye drops for adults.

  Recruiting Phase 4 The Cleveland Clinic · Cleveland, Ohio · NCT04371445

• Examining visual function in children with amblyopia and strabismus during treatment

  This study is testing how different treatments for amblyopia and strabismus, like patching and glasses, can improve vision in children by checking their eye movements and clarity before and after treatment.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT04310241

• Evaluating sacubitril-valsartan for heart failure patients with LVADs

  This study is testing if a new heart medication called sacubitril-valsartan is safe and effective for adults with severe heart failure who have a special heart pump called an LVAD.

  Recruiting Phase 4 The Cleveland Clinic · Cleveland, Ohio · NCT04191681

• Comparing imaging methods for heart valve disease assessment

  This study is testing whether a new 3D heart imaging method is better than the traditional 2D method for checking how serious heart valve problems are in people with conditions like aortic stenosis and mitral valve regurgitation.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT04126018

• Protein supplement to reduce hospital readmissions for liver disease patients

  This study is testing if a protein supplement can help liver disease patients who have had hospital stays for brain issues feel better and avoid going back to the hospital.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT04096014

• Investigating blood responses in healthy individuals, heavy drinkers, and patients with alcoholic hepatitis

  This study looks at how blood responses differ between healthy people, heavy drinkers, and those with alcoholic hepatitis to better understand inflammation and liver disease.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT04088370

• Evaluating muscle protein metabolism in patients with cirrhosis

  This study is testing how muscle protein is made and broken down in people with cirrhosis to better understand why they lose muscle.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT03225677

• Comparison of patients with alcoholic liver disease and healthy controls

  This study is collecting samples from people with alcoholic liver disease and healthy individuals to see how certain markers and genes might affect the disease and its treatment.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT03224949

• Ethanol's effect on muscle autophagy in alcoholic liver disease

  This study is testing how alcohol affects muscle health in people with alcoholic liver disease by looking at how it breaks down certain proteins in their muscles.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT03209791

• Using leucine to reverse muscle loss in cirrhosis

  This study is testing if a special mixture of amino acids, including leucine, can help people with cirrhosis regain lost muscle and improve their strength.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT03208868

• Examining malnutrition mechanisms in cirrhosis patients

  This study is trying to understand how malnutrition happens in people with cirrhosis by looking at muscle and fat loss, and comparing them to healthy individuals.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT03121404

• Measuring corneal properties to predict treatment outcomes

  This study is testing new ways to measure the shape and strength of the cornea to see if it can help predict how well treatments like LASIK will work for people with keratoconus or those needing eye surgery.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT03030755

• Prophylactic foraminotomy to prevent C5 palsy after cervical spine surgery

  This study tests if a specific surgical procedure can help prevent C5 palsy, which causes weakness in the arms, in patients having surgery for neck problems.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT03023696

• Understanding the genetics of uveitis

  This study is trying to find out if there are specific genetic factors in people with uveitis by looking at their blood samples to help improve how we understand and manage the condition.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT02357238

• Dietary changes to reduce gut bacteria's impact on heart health

  This study is testing whether changing what people eat can lower a harmful compound linked to heart problems, specifically in those with high levels of it.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT02016430

• Using OCT scans to analyze eye inflammation in uveitis patients

  This study is testing if OCT scans can help doctors see and measure eye inflammation in people with uveitis.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT01746537

• Collection of blood and tissue samples for cardiac arrhythmias

  This study is collecting blood and tissue samples from people with heart rhythm problems and healthy individuals to see if there are any genetic clues that could help us understand these conditions better.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT00921986

Quick answers

How many clinical trials run by The Cleveland Clinic are recruiting right now?

127, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 15 countries. The most sites are in United States (125 trials), Brazil (1 trial), Canada (1 trial), Finland (1 trial), India (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 12, Phase 2: 6, Phase 3: 4, Early Phase 1: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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