NIRAF imaging to help parathyroid removal when preoperative tests don’t locate glands

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study evaluates the use of near-infrared autofluorescence (NIRAF) imaging as an intraoperative aid for identifying parathyroid glands during bilateral neck exploration in primary hyperparathyroidism. Participants undergo parathyroidectomy guided by NIRAF in addition to standard preoperative imaging. The study focuses on whether NIRAF can improve gland identification when preoperative localization is negative or inconclusive. The trial is conducted at Cleveland Clinic with patients scheduled for parathyroidectomy and no additional concurrent neck procedures. Outcomes of interest include identification success, operative details, and short-term postoperative results.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosed with primary hyperparathyroidism
* Undergoing bilateral neck exploration
* Will under go only parathyroidectomy surgery

Exclusion Criteria:

* Diagnosed with secondary or tertiary hyperparathyroidism
* Undergoing focal PG exploration
* Will undergo concomitant surgery (total thyroidectomy, thyroid lobectomy)

Where it's running

• Cleveland Clinic
  Cleveland, Ohio, United States Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Role of LH and hCG in adults being evaluated for endocrine disorders

  This study looks at whether levels of luteinizing hormone (LH) and hCG in adults undergoing endocrine evaluation relate to their disease presence and outcomes.

  Recruiting Copenhagen University Hospital at Herlev · Herlev · NCT07824102

• 18F‑Fluorocholine PET/MRI and NeuroEXPLORER PET/CT to locate parathyroid tumors

  This trial will test whether 18F‑Fluorocholine PET/MRI and NeuroEXPLORER PET/CT scans can better find overactive or cancerous parathyroid glands in adults scheduled for surgery.

  Recruiting Phase 2/3 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT07444723

• Amino acid transporter PET/CT imaging with MET/FET for AATS-related tumors

  This project tries PET/CT scans using 11C- or 18F-labeled MET/FET tracers to see if they better find primary or metastatic lesions in adults with amino acid transporter–related tumors such as glioma and primary hyperparathyroidism.

  Recruiting at 3 sites Tianjin Medical University · Hefei, Anhui and 2 other locations · NCT07379463

• Using 18F‑choline PET/CT versus ultrasound and sestamibi to locate diseased parathyroid glands

  This trial tests whether 18F‑choline PET/CT can better locate diseased parathyroid glands than ultrasound and sestamibi scans in adults with primary hyperparathyroidism who are scheduled for surgery.

  Recruiting Region Skane · Lund · NCT07138820

• Effects of zoledronic acid before parathyroid surgery in patients with primary hyperparathyroidism

  This study tests if giving a single dose of zoledronic acid before parathyroid surgery can help improve bone health and overall well-being for people with primary hyperparathyroidism.

  Recruiting Phase 4 University of Aarhus · Aarhus N, Central Region of Denmark · NCT06859580

• Understanding genetic causes of neuroendocrine tumors in Mexican patients

  This study is trying to find out the genetic changes that cause neuroendocrine tumors in Mexican patients to help develop better treatments.

  Recruiting at 3 sites Universidad Nacional Autonoma de Mexico · Mexico City, Mexico City and 2 other locations · NCT06523582

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.