Using OCT scans to analyze eye inflammation in uveitis patients
Official title: Automated Analysis of Anterior Chamber Inflammation by Optical Coherence Tomography
Run by The Cleveland Clinic · NCT01746537 · Data updated 2026-11-12
This study is testing if OCT scans can help doctors see and measure eye inflammation in people with uveitis.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 1500 (estimated) |
| Sponsor | The Cleveland Clinic Academic / other |
| Locations | 1 site (Cleveland, Ohio) |
| Status | Recruiting |
| Started | June 2012 |
| Main results expected | June 2028 |
| Study ends | June 2029 |
| Registry record updated | March 4, 2026 |
| Trial ID | NCT01746537 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients presenting with uveitis at the Cole Eye Institute.
✕Probably not a fit
Patients who are unable to provide informed consent or have severe corneal opacities that prevent imaging will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to investigate the feasibility of using Optical Coherence Tomography (OCT) scans to assess anterior chamber inflammation in patients diagnosed with uveitis. By conducting a prospective case series, the study will gather data from patients presenting at the Cole Eye Institute. The focus is on evaluating the effectiveness of OCT as a diagnostic tool for monitoring inflammation in the anterior chamber of the eye.
Why it matters
Potential benefit: If successful, this study could enhance the diagnostic capabilities for uveitis, leading to better management and treatment outcomes for patients.
How similar studies have gone: While this approach is relatively novel, similar studies using OCT for other ocular conditions have shown promising results.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * All patients presenting to Cole Eye Institute with uveitis. Exclusion Criteria: * Inability to provide informed consent, including non-English speaking and cognitively/mentally impaired. * Severe corneal opacities preventing imaging of anterior chamber
Where it's running
-
Cole Eye Institute
Cleveland, Ohio, United States Recruiting
Study contacts
- Principal investigator: Sunil K Srivastva, MD — The Cleveland Clinic
- Study coordinator: Sunil K Srivastava, M.D.
- Phone: 216-636-2286
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Ocular Fluid Work-up in Presumed Trematode-Induced Granulomatous Uveitis
This study tests ocular fluid samples from patients with presumed trematode-induced granulomatous uveitis who are having eye surgery to look for clues about the cause.
-
PANDA-ASOCT: Detecting Uveitis in Children with Automated Eye Image Analysis
This study tests a high-speed, non-invasive eye imaging system with automated analysis to help detect uveitis in children and young people who attend a clinic for uveitis or juvenile idiopathic arthritis.
-
GenSci048 vs placebo in active non-infectious uveitis
This study tests whether GenSci048 can help people with active non-infectious uveitis compared with placebo.
-
Uveitis in children under 18
This project collects medical information from children with uveitis to see how often different types occur and what treatments and clinical features look like.
-
Metagenomic testing for infections in people with eye inflammation
This project will test metagenomic sequencing on eye fluid to find infections in adults with unexplained ocular inflammation who are at risk of vision loss.
-
Observational study on chronic uveitis in children
This study is trying to gather information about chronic uveitis in children to improve how doctors diagnose and treat this rare eye condition.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.