Long-term follow-up of MRI markers (central vein sign and paramagnetic rim lesions) in multiple sclerosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a 48-month extension of the CAVS‑MS effort that will follow 40 participants at three U.S. centers to collect serial MRIs and compare CVS and PRL findings over time. Participants who completed the 24‑month CAVS‑MS visit will undergo additional MRI visits, including contrast-enhanced sequences, to document lesion characteristics and changes. The study will measure how well CVS helps distinguish MS lesions from mimics and whether PRLs predict clinical course or lesion evolution. Results will provide pilot longitudinal data to inform a larger multicenter follow-up effort.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Participants must be enrolled in and meet all inclusion criteria of the CAVS-MS study.
* Must have participated in the CAVS-MS study and have completed month 24 visits.
* Able to provide written informed consent to participate in the study.

Exclusion Criteria:

* Contraindication to MRI studies; metal or metal implants incompatible with MRI
* Inability to tolerate MRI due to claustrophobia or known excessive movement (e.g. tremor).

Where it's running

• Cleveland Clinic Foundation
  Cleveland, Ohio, United States Recruiting
• Cedars-Sinai Medical Center
  Los Angeles, California, United States Not yet recruiting
• University of Pennsylvania
  Philadelphia, Pennsylvania, United States Not yet recruiting

Study contacts

• Principal investigator: Daniel Ontaneda, MD, PHD — The Cleveland Clinic
• Study coordinator: Meghan Kilbane
• Email: kilbanm@ccf.org
• Phone: 216-445-9845

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.