Personalized deep brain stimulation for Parkinson's disease
Official title: Identifying Circuit Dynamics Underlying Motor Dysfunction in Parkinson's Disease Using Real-Time Neural Control
Run by The Cleveland Clinic · NCT06013956 · Data updated 2026-11-12
This study is testing a new personalized deep brain stimulation approach for people with Parkinson's disease to see if it can better manage their motor symptoms by adjusting to their brain activity in real-time.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 25 (estimated) |
| Sponsor | The Cleveland Clinic Academic / other |
| Locations | 1 site (Cleveland, Ohio) |
| Status | Recruiting |
| Started | August 29, 2023 |
| Main results expected | June 30, 2028 |
| Study ends | June 30, 2028 |
| Registry record updated | August 20, 2026 |
| Trial ID | NCT06013956 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals diagnosed with idiopathic Parkinson's disease who are eligible for DBS surgery.
✕Probably not a fit
Patients with secondary Parkinsonism or other significant central nervous system diseases may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study involves a cohort of patients who are scheduled for deep brain stimulation (DBS) surgery to treat Parkinson's disease. It aims to explore the role of beta band oscillations in the basal ganglia and how they relate to motor symptoms of Parkinson's disease. By utilizing closed-loop electrical neurostimulation and computational modeling, the study seeks to develop a personalized DBS technology that can adapt in real-time based on individual neural activity. The research will help clarify the causal relationship between neural oscillations and motor signs, potentially leading to improved treatment strategies.
Why it matters
Potential benefit: If successful, this study could lead to more effective and personalized treatment options for patients with Parkinson's disease.
How similar studies have gone: While there have been studies on DBS and Parkinson's disease, this approach utilizing real-time closed-loop neuromodulation is novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Key Inclusion Criteria: * Ability to provide informed consent. * Clinical diagnosis of idiopathic Parkinson's disease. * Determined, as per standard of care, to be a candidate for deep brain stimulation (DBS) surgery targeting the subthalamic nucleus. * Ability to tolerate delays in taking daily standard Parkinson's disease medications. Key Exclusion Criteria: * Secondary Parkinsonism, stroke, or progressive central nervous system disease other than Parkinson's disease. * Patient has a condition that, in the opinion of the investigators, would significantly increase the risk of interfering with study compliance, safety, or outcome.
Where it's running
-
Cleveland Clinic
Cleveland, Ohio, United States Recruiting
Study contacts
- Study coordinator: David Escobar, PhD
- Email: escobad2@ccf.org
- Phone: 216-390-1907
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
One-day exercise test to see how brain and body react in epilepsy, cognitive disorders, Parkinson's, dementia, and related conditions
A one-day study tests how an acute bout of exercise changes brain function and bodily signals in people with certain neurological conditions compared with healthy individuals.
-
Tributyrin for PSP: a virtual, early-phase study
This study tests whether tributyrin is safe and tolerable in people with Progressive Supranuclear Palsy who are 45 or older, using virtual visits.
-
A look at why Lewy body conditions cause visual hallucinations
This study tests brain‑imaging in people with Lewy body diseases who do or don’t experience visual hallucinations, and in healthy volunteers, to see how brain networks might create these images.
-
How physical activity might help people with Parkinson’s disease who have DBS-STN implants
This study tests whether adding regular physical activity can help people with Parkinson’s who have DBS-STN stimulation by trying a structured physiotherapy approach alongside standard care.
-
Can hippotherapy improve mobility, gait, balance, and quality of life in people with Parkinson's disease?
This pilot trial tests whether adding horse-assisted therapy to standard rehab helps mobility, gait, balance, and perceived health in adults with Parkinson's disease.
-
Gut methane and Parkinson's: measuring if a probiotic helps people with Parkinson's, REM sleep behavior disorder, or cognitive concerns
This study tests whether a probiotic containing Limosilactobacillus reuteri can help people with Parkinson's disease, those at high risk for PD, and related cognitive issues by potentially improving gut methane levels and overall symptoms.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.