Personalized deep brain stimulation for Parkinson's disease
Identifying Circuit Dynamics Underlying Motor Dysfunction in Parkinson's Disease Using Real-Time Neural Control
This study is testing a new personalized deep brain stimulation approach for people with Parkinson's disease to see if it can better manage their motor symptoms by adjusting to their brain activity in real-time.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 25 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | The Cleveland Clinic Academic / other |
| Locations | 1 site (Cleveland, Ohio) |
| Trial ID | NCT06013956 on ClinicalTrials.gov |
What this trial studies
This study involves a cohort of patients who are scheduled for deep brain stimulation (DBS) surgery to treat Parkinson's disease. It aims to explore the role of beta band oscillations in the basal ganglia and how they relate to motor symptoms of Parkinson's disease. By utilizing closed-loop electrical neurostimulation and computational modeling, the study seeks to develop a personalized DBS technology that can adapt in real-time based on individual neural activity. The research will help clarify the causal relationship between neural oscillations and motor signs, potentially leading to improved treatment strategies.
Who should consider this trial
Good fit: Ideal candidates are individuals diagnosed with idiopathic Parkinson's disease who are eligible for DBS surgery.
Not a fit: Patients with secondary Parkinsonism or other significant central nervous system diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more effective and personalized treatment options for patients with Parkinson's disease.
How similar studies have performed: While there have been studies on DBS and Parkinson's disease, this approach utilizing real-time closed-loop neuromodulation is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Key Inclusion Criteria: * Ability to provide informed consent. * Clinical diagnosis of idiopathic Parkinson's disease. * Determined, as per standard of care, to be a candidate for deep brain stimulation (DBS) surgery targeting the subthalamic nucleus. * Ability to tolerate delays in taking daily standard Parkinson's disease medications. Key Exclusion Criteria: * Secondary Parkinsonism, stroke, or progressive central nervous system disease other than Parkinson's disease. * Patient has a condition that, in the opinion of the investigators, would significantly increase the risk of interfering with study compliance, safety, or outcome.
Where this trial is running
Cleveland, Ohio
- Cleveland Clinic — Cleveland, Ohio, United States (Recruiting)
Study contacts
- Study coordinator: David Escobar, PhD
- Email: escobad2@ccf.org
- Phone: 216-390-1907
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.