Smell training in CRS patients with smell loss

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with chronic rhinosinusitis with nasal polyps and smell loss will undergo a baseline assessment of smell function, mental health, disease severity, and immune markers, followed by a 3-month smell training program. A subset, including healthy controls, will provide comparison data and baseline measurements only. The study will analyze tissue and blood samples to find molecules linked to smell loss and explore potential links to cognition. Outcomes include changes in olfactory function, immune profile, and mental health after training. Control participants will not have follow-up testing beyond baseline.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age less than 18 years-old
* Present to rhinology clinic with CRS with nasal polyps
* Sense of smell loss for any reason (other than trauma or tumor)

Exclusion Criteria:

* Patients \< 18 years of age
* Individuals with unilateral nasal polyps
* Autoimmune diseases
* Ciliary disorders
* Cystic fibrosis
* Smell loss due to tumors or trauma

Where it's running

• The Cleveland Clinic
  Cleveland, Ohio, United States Recruiting

Study contacts

• Principal investigator: Mohamad Chaaban, MD — The Cleveland Clinic
• Study coordinator: John O'Neill
• Email: ONEILLJ2@ccf.org
• Phone: 4405062611

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.