Managing necrotizing soft tissue infections with specialized wound matrices

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial is a prospective, pilot, parallel group, randomized controlled trial conducted at the Cleveland Clinic Foundation. It compares the effectiveness of Cytal® Wound Matrix and MicroMatrix® against standard care dressings in treating necrotizing fasciitis. Participants will undergo wound debridement by surgical staff, and the specialized treatments will be applied by trained co-investigators. Data will be securely collected using REDCap, and the study will adhere to ethical standards with IRB approval and informed consent.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Adults (≥ 18 years) with a diagnosis of necrotizing fasciitis
2. Wound ≥ 30 cm2
3. The participant is willing and able to adhere to protocol requirements and agrees to participate in the study program and comply with the study follow-up regimen.

Exclusion Criteria:

1. Burn as etiology of wound
2. Acute osteomyelitis requiring active treatment
3. Known allergy, hypersensitivity, or objection to porcine materials
4. Pregnant participants
5. Lack of English language fluency
6. Participant report of concurrent participation in another clinical trial that would interfere with this study
7. Inability to consent

Where it's running

• Cleveland Clinic
  Cleveland, Ohio, United States Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.