Training program to prepare patients for epilepsy surgery
Official title: Readiness Brain Operation Optimization Training (ReBOOT) for Epilepsy Surgery
Run by The Cleveland Clinic · NCT05992402 · Data updated 2026-11-12
This study is testing a new training program for people with epilepsy to see if it helps them feel better and have a smoother experience before and after surgery compared to standard care.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 60 Years |
| Sex | All |
| Enrollment | 64 (estimated) |
| Sponsor | The Cleveland Clinic Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Cleveland, Ohio) |
| Status | Recruiting |
| Started | December 6, 2023 |
| Main results expected | June 2028 |
| Study ends | June 2028 |
| Registry record updated | June 18, 2026 |
| Trial ID | NCT05992402 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18-60 with diagnosed epilepsy who are confirmed surgical candidates and can provide informed consent.
✕Probably not a fit
Patients who have undergone cognitive rehabilitation in the last 6 months or are involved in ongoing litigation related to their epilepsy may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to evaluate the effectiveness of a new educational program designed to prepare patients for epilepsy surgery, potentially reducing the risk of cognitive decline post-surgery. Participants will engage in two individual virtual sessions and four group sessions over 5-6 weeks, alongside completing online surveys and questionnaires. The study will compare outcomes between those who undergo the educational program and those receiving standard care, focusing on quality of life and surgical satisfaction. Researchers will also assess the feasibility of the program through attendance tracking and patient feedback.
Why it matters
Potential benefit: If successful, this program could help patients maintain cognitive function and improve their overall experience and satisfaction with epilepsy surgery.
How similar studies have gone: While similar cognitive interventions have shown promise in other contexts, this specific approach for epilepsy surgery is novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults, aged 18-60 years old, with diagnosed epilepsy who have been confirmed as an appropriate surgical candidate by their epileptologist * Able to independently provide informed consent * Fluent in English * Reading abilities at or above 8th grade level as determined by the Wide Range Achievement Test- 4th Edition (WRAT-4), Reading subtest. * Internet access and the ability to participate in online video streaming * No history of resective or ablative neurosurgery, but this does not include neuromodulation therapies for epilepsy (e.g., RNS, VNS, DBS) * Willing and able to participate in cognitive intervention Exclusion Criteria: * Any patient that has engaged in any form of cognitive rehabilitation/intervention within the last 6 months * Ongoing litigation related to the cause of epilepsy, unless litigation is related to short term or long-term disability application. * Undergoing intensive medical treatment for serious or life-threatening illness (e.g., chemotherapy, etc.) that would impact study participation. * Serious psychiatric condition that could interfere with participation, such as schizophrenia, active psychosis, active mania, and current suicidal ideation. * Significant hearing and/or vision loss that would preclude them from participating in remote cognitive testing and engaging in the cognitive intervention.
Where it's running
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Cleveland Clinic
Cleveland, Ohio, United States Recruiting
Study contacts
- Principal investigator: Kayela Arrotta, PhD — The Cleveland Clinic
- Study coordinator: Kayela Arrotta, PhD
- Email: ArrottK@ccf.org
- Phone: 216-444-6101
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.