Measuring corneal properties to predict treatment outcomes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research aims to develop tools for measuring and simulating individual responses to corneal treatments, focusing on patients with keratoconus and those undergoing refractive surgery like LASIK. Participants will have their eyes imaged using optical coherence tomography to assess corneal mechanical properties, and computational models will be created to predict how the cornea will respond to various treatments. The study seeks to validate the hypothesis that these models can accurately forecast changes in corneal shape within acceptable error limits.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Any patient with keratoconus diagnosed by standard criteria, including topographic steepness, irregular astigmatism with a pattern consistent with keratoconus.
* Any patient deemed a candidate for LASIK (laser vision correction) and scheduled for surgery.

Exclusion Criteria:

* Inability to provide informed consent, including non-English speaking (if interpreter not available) and cognitively/mentally impaired (if legal guardian not available).

Where it's running

• Cleveland Clinic Foundation Cole Eye Institute
  Cleveland, Ohio, United States Recruiting

Study contacts

• Principal investigator: William Dupps, MD — The Cleveland Clinic
• Study coordinator: Pamela Hoffman, MS
• Email: moorehp@ccf.org
• Phone: 216-445-5248

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Evaluating pain pathways and nerve regeneration in keratoconus patients after corneal crosslinking

  This study is testing how corneal crosslinking affects pain and nerve healing in people with keratoconus to see how their pain changes over time.

  Recruiting Boston Children's Hospital · Boston, Massachusetts · NCT04439552

• Testing Brillouin Microscopy for Diagnosing Corneal Conditions

  This study is testing a new imaging technique called Brillouin microscopy to see if it can better diagnose corneal issues like keratoconus and ectasia in people.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT02118922

• Corneal Crosslinking to Treat Progressive Keratoconus or Corneal Ectasia

  This study tests two different light durations used in corneal crosslinking to see which better helps people with keratoconus or corneal ectasia.

  Recruiting Phase 2/3 Price Vision Group · Indianapolis, Indiana · NCT07841470

• Brillouin hydration mapping to study cornea health

  Researchers test a Brillouin microscope to see if it can measure corneal water content in healthy people and those with eye conditions.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT07780890

• Auricular Acupressure to Help Prevent Myopia in Young Kids With Limited Hyperopic Reserve

  This trial tests whether auricular acupressure, added to standard eye health education, can help prevent myopia in elementary students who don’t have enough hyperopic reserve.

  Recruiting Shanghai Eye Disease Prevention and Treatment Center · Shanghai, Shanghai Municipality · NCT07746804

• Myopia control for kids using defocus lenses with ear acupressure in school

  This trial tests whether adding auricular acupressure to defocus spectacle lenses can better slow myopia progression in primary school children with premyopia or myopia.

  Recruiting Shanghai Eye Disease Prevention and Treatment Center · Shanghai, Shanghai Municipality · NCT07746778

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.