Comparing two ways of taking acid-blocking medications for stomach ulcers after gastric bypass surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to determine the effectiveness of taking proton pump inhibitors (PPIs) in two different forms: as an open capsule versus an intact capsule for treating marginal ulcers in patients who have undergone gastric bypass surgery. Participants diagnosed with marginal ulcers will be instructed to take either the contents of the capsule or the whole capsule, with their healing monitored through regular upper endoscopies. The study seeks to assess whether the open-capsule method leads to better healing outcomes and fewer complications compared to the traditional method. This is the first trial of its kind to explore this approach in this patient population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Subjects diagnosed with marginal ulceration post-gastric bypass on upper endoscopy

Exclusion Criteria:

* Refusal to start PPI medication OR current open-capsule PPI use at the time of diagnosis of the marginal ulcer

Where it's running

• Cleveland Clinic Foundation
  Cleveland, Ohio, United States Recruiting

Study contacts

• Principal investigator: Stephen Firkins, MD — The Cleveland Clinic
• Study coordinator: Stephen Firkins, MD
• Email: bariatricendoscopy@ccf.org
• Phone: 216-444-8460

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Treatment of marginal ulcers using low-thermal argon plasma

  This study is testing if a new low-thermal argon plasma treatment can help heal stubborn ulcers that some people get after weight loss surgery, to see if it works better than the usual medicine.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06543316

• Choose Myself (Before) Losing Myself

  We’re testing an educational interactive booklet to help people with dementia or memory problems think about future medical decisions and start conversations with family or caregivers.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07846566

• Endurance exercise to see if it lowers alcohol use in adults with AUD and ALD

  A 12-week home-based cycling program added to standard care is tested to see if it reduces alcohol use and cravings in adults with alcohol use disorder and alcohol-related liver disease.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07824089

• Robotic adrenalectomy with imaging to guide dissection using a dye

  A randomized comparison tests whether adding indocyanine green (ICG) imaging during robotic adrenalectomy helps surgeons find the adrenal gland and perform the operation.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07813247

• NIRAF imaging to help parathyroid removal when preoperative tests don’t locate glands

  This trial tests whether using an NIRAF camera during parathyroid surgery helps find and remove abnormal glands in people with primary hyperparathyroidism when prior imaging hasn’t pinpointed them.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07812649

• 4D intracardiac echocardiography to guide left atrial appendage occlusion procedures

  A new 4D ICE catheter is being tested alongside standard imaging to see if it can safely guide left atrial appendage occlusion procedures for adults with atrial fibrillation.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07806890

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.