Exploring how genetics and exercise can slow Parkinson's disease progression

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The Genetics and Aerobic Exercise to Slow Parkinson's Disease Trial aims to investigate the relationship between genetics and high-intensity aerobic exercise in altering the progression of Parkinson's disease. This multi-site trial will recruit 200 patients from Cleveland and Salt Lake City to participate in a community-based exercise program, 'Pedaling for Parkinson's', where they will engage in cycling three times a week for 12 months. Participants will undergo genetic testing to assess their polygenic risk scores, which will help determine how genetic factors influence the effectiveness of exercise in slowing disease progression. The study includes multiple assessments to evaluate the impact of exercise on Parkinson's symptoms while considering the genetic background of the participants.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Adult with a diagnosis of PD by a physician or physician extender
2. Hoehn and Yahr stage I-III
3. Demonstrate the ability to safely mount and dismount a stationary cycle
4. Reliable transportation to the community exercise facility
5. Smartphone device for activity data monitoring
6. On a stable dose of anti-parkinsonian medication

Exclusion Criteria:

1. Participation in disease modifying PD-related clinical trial or study
2. Diagnosis of dementia or any neurocognitive impairment that compromises one's ability to provide informed consent.
3. Implanted deep brain stimulation electrodes or focused ultrasound for PD management
4. Recommendation for medical clearance using the American College of Sports Medicine (ACSM) Preparticipation Health Screen a. If the ACSM screen recommends medical clearance, the participant must obtain medical clearance by their health care provider prior to participation.

b. Those who choose not to obtain physician clearance will not be eligible for participation.

e) A musculoskeletal issue (arthritis, osteoporosis, back problem) that would limit one's ability to engage in a cycling intervention f) Neurological disease other than Parkinson's disease (i.e. multiple sclerosis, stroke) g) Current cardiac arrhythmia

Where it's running

• The Cleveland Clinic
  Cleveland, Ohio, United States Recruiting

Study contacts

• Study coordinator: Elizabeth Jansen, MPH
• Email: jansena@ccf.org
• Phone: 216-780-9160

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.