Understanding the genetics of uveitis
Official title: Genetics of Uveitis
Run by The Cleveland Clinic · NCT02357238 · Data updated 2026-11-12
This study is trying to find out if there are specific genetic factors in people with uveitis by looking at their blood samples to help improve how we understand and manage the condition.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 6 Years and up |
| Sex | All |
| Enrollment | 1500 (estimated) |
| Sponsor | The Cleveland Clinic Academic / other |
| Locations | 1 site (Cleveland, Ohio) |
| Status | Recruiting |
| Started | January 2011 |
| Main results expected | January 2030 |
| Study ends | January 2030 |
| Registry record updated | March 4, 2026 |
| Trial ID | NCT02357238 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include patients diagnosed with uveitis or infectious uveitis, such as those with toxoplasmosis retinochoroiditis or herpes-associated retinitis.
✕Probably not a fit
Patients who are unable to provide consent or from whom an adequate blood sample cannot be obtained will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to enhance knowledge about uveitis by collecting blood samples from patients diagnosed with the condition. The researchers will isolate DNA from these samples and perform sequencing to identify any genetic mutations or associations linked to uveitis and infectious uveitis. The goal is to uncover the underlying mechanisms of the disease, which could lead to better understanding and management of uveitis.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnosis and treatment strategies for patients with uveitis.
How similar studies have gone: While the specific genetic associations in uveitis may be novel, similar genetic studies in other autoimmune conditions have shown promising results.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Any patient above with the diagnosis of uveitis. * Any patient with a diagnosis of infectious uveitis such as toxoplasmosis retinochoroiditis, herpes associated retinitis. Exclusion Criteria: * Patients who are unable to give consent * Patients in whom an adequated blood sample can not be obtained.
Where it's running
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Cleveland Clinic Foundation
Cleveland, Ohio, United States Recruiting
Study contacts
- Principal investigator: Sunil K. Srivastava, M.D. — The Cleveland Clinic
- Study coordinator: Kimberly M Baynes, BSN, RN, COA
- Email: baynesk@ccf.org
- Phone: 216-444-2566
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Ocular Fluid Work-up in Presumed Trematode-Induced Granulomatous Uveitis
This study tests ocular fluid samples from patients with presumed trematode-induced granulomatous uveitis who are having eye surgery to look for clues about the cause.
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PANDA-ASOCT: Detecting Uveitis in Children with Automated Eye Image Analysis
This study tests a high-speed, non-invasive eye imaging system with automated analysis to help detect uveitis in children and young people who attend a clinic for uveitis or juvenile idiopathic arthritis.
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GenSci048 vs placebo in active non-infectious uveitis
This study tests whether GenSci048 can help people with active non-infectious uveitis compared with placebo.
-
Uveitis in children under 18
This project collects medical information from children with uveitis to see how often different types occur and what treatments and clinical features look like.
-
Metagenomic testing for infections in people with eye inflammation
This project will test metagenomic sequencing on eye fluid to find infections in adults with unexplained ocular inflammation who are at risk of vision loss.
-
Observational study on chronic uveitis in children
This study is trying to gather information about chronic uveitis in children to improve how doctors diagnose and treat this rare eye condition.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.