Comparing cold and hybrid techniques for removing large colon polyps

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to determine whether a hybrid approach combining cold endoscopic mucosal resection (EMR) with traditional cold EMR can reduce the risk of polyp recurrence while minimizing complications in patients with large colon polyps. Participants will undergo EMR and will return for a follow-up endoscopy in 3-6 months to assess for any recurrence of polyps. The study focuses on adults with specific polyp characteristics, ensuring a targeted approach to treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patient (age 18 years or older)
* Polyp size of at least 20 mm
* \- Morphology: Flat or superficially raised polyp morphology (i.e., Paris classification 1s, 0-IIa or 0-IIb, or a combination of the above)

Exclusion Criteria:

* Polyps with previous failed resection attempts or polyp recurrence
* Suspected deep submucosal invasion on endoscopic assessment of surface mucosal pit pattern (Kudo V or NICE 3 pattern) or histologically confirmed malignancy (invasive adenocarcinoma)
* Polyps with nodules too large (\>1-1.5cm) for the use of a cold snare
* Inflammatory bowel disease

Where it's running

• Cleveland Clinic Weston
  Weston, Florida, United States Recruiting
• Cleveland Clinic
  Cleveland, Ohio, United States Recruiting

Study contacts

• Principal investigator: Tilak Shah, M.D. — Cleveland Clinic Florida (Weston Hospital)
• Study coordinator: Akram Ahmad, M.D.
• Email: ahmada5@ccf.org
• Phone: 954-659-5000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.