Comparing two types of nerve blocks for pain management in upper abdominal surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to compare the effectiveness of two different nerve blocks, the external oblique fascial plane (EOIFP) block and the Oblique Subcostal Transversus Abdominis Plane (OSTAP) block, in managing postoperative pain for patients undergoing open upper abdominal surgery. Conducted at the Cleveland Clinic Main Campus, the study will randomly assign participants to receive one of the two blocks, with both patients and outcome assessors blinded to the group assignments. The blocks will be performed under ultrasound guidance, and the study will evaluate pain management outcomes over the postoperative period.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Written informed consent;
* 18-85 years old;
* ASA Physical Status 1-3
* Scheduled for elective open upper abdominal surgery with supraumbilical incision (gastrectomy, hepatectomy, pancreatectomy, splenectomy, supraumbilical ventral hernia repair).
* Anticipated hospitalization of three nights;
* Expected requirement for parenteral opioids for at least 48 hours for postoperative pain

Exclusion Criteria:

* Hepatic disease, e.g. twice the normal levels of liver enzymes;
* Chronic kidney disease according to GFR (may be stage 3 or worse as defined by a GFR \<60
* Allergic reaction to study medications;
* Women who are pregnant or breastfeeding;
* Nephrectomy or lower abdominal surgeries such as hysterectomy, colorectal surgeries
* Patient refusal

Where it's running

• Cleveland Clinic Foundation
  Cleveland, Ohio, United States Recruiting

Study contacts

• Principal investigator: Ehab Farag, MD — The Cleveland Clinic
• Study coordinator: Fabio Rodriguez, MD
• Email: rodrigf3@ccf.org
• Phone: 216-444-9950

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.