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Clinical trial Recruiting at 1 site Observational Ages 18 and up

Examining heart changes in patients undergoing rehabilitation or bariatric surgery

Official title: Cardiovascular Imaging to Assess Responses to Metabolic Interventions

Run by The Cleveland Clinic · NCT05650307 · Data updated 2026-11-12

This study is testing how heart changes in people improve after they go through rehabilitation or weight-loss surgery to see if these changes can help spot heart problems early.

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Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment150 (estimated)
SponsorThe Cleveland Clinic
Academic / other
Locations1 site (Cleveland, Ohio)
StatusRecruiting
StartedSeptember 9, 2022
Main results expectedSeptember 9, 2027
Study endsSeptember 9, 2027
Registry record updatedMay 8, 2026
Trial IDNCT05650307 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include adults over 18 years with symptomatic cardiovascular disease or those eligible for bariatric surgery.

Probably not a fit

Patients with contraindications to MRI or those from vulnerable populations, such as prisoners, may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate how cardiac microstructure changes in patients before and after undergoing cardiac rehabilitation or bariatric surgery. Using cardiac MRI, the study will assess the relationship between these microstructural changes and overall cardiac function and structure. The research will involve a longitudinal cohort design, with participants undergoing MRI scans at the beginning and end of a 12-week rehabilitation program. The goal is to identify early indicators of cardiovascular disease through these imaging techniques.

Why it matters

Potential benefit: If successful, this study could lead to improved early detection and management of cardiovascular diseases in patients undergoing metabolic interventions.

How similar studies have gone: Other studies have shown promising results in using cardiac MRI to assess heart conditions, suggesting that this approach may yield valuable insights.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Age \> 18 years of age
* Provision of written informed consent
* For bariatric surgery group, obesity (BMI\>/=30 kg/m2) and non-obese (BMI \<30 kg/m2; for control group)
* For cardiac rehabilitation group, symptomatic cardiovascular disease for patients and no signs of cardiovascular disease for healthy controls

Exclusion Criteria:

* Vulnerable populations will be excluded from this study including Prisoners
* Contraindication to CMR imaging to be determined by standard MRI protocols
* Decisionally impaired (e.g. dementia or cognitive disability)

Where it's running

  • Cardiovascular Innovation Research Center
    Cleveland, Ohio, United States     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Bariatric Surgery Candidate 47Heart Failure 1020Cardiovascular Diseases 365The Cleveland Clinic 127
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.