Comparing two types of anesthesia for esophageal cancer surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to compare the effectiveness of propofol-based total intravenous anesthesia versus sevoflurane-based balanced general anesthesia in patients undergoing potentially curative surgery for esophageal cancer. The primary focus is on measuring recurrence-free survival rates post-surgery, with secondary goals including the speed of discharge from the ICU and hospital, as well as the quality of recovery assessed by the QoR-15 scale on postoperative day 2. Patients will be randomly assigned to one of the two anesthesia methods to evaluate these outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Primary esophageal cancer without known extension beyond the esophagus. (i.e. believed to be Tumor Stage 1-3).
* Scheduled for potentially curative esophageal cancer surgery.
* Written informed consent, including willingness to be randomized to intravenous versus volatile anesthesia.

Exclusion Criteria:

* Previous surgery for esophageal cancer (except diagnostic biopsies) Age \<18 or \>85 years old.
* ASA Physical Status ≥4.
* Any contraindication to propofol or sevoflurane.
* Other cancer not believed by the attending surgeon to be in long-term remission.
* Systemic disease believed by the attending surgeon to present ≥25% two- year mortality.

Where it's running

• Shanhai Chest Hospital
  Shanghai, China Recruiting

Study contacts

• Principal investigator: Yuwei Qiu, MD — Shahai Hospital
• Study coordinator: Yuwei Qiu, MD
• Email: qiuyuweixk@163.com
• Phone: 86 21 6282 1990

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.