Intensive hypertension management program at Cleveland Clinic
Official title: Implementation of Intensive Hypertension Management Approaches: Cleveland Clinic
Run by The Cleveland Clinic · NCT07232017 · Data updated 2026-11-12
This program will try team-based medication adjustments guided by home blood pressure readings to lower very high blood pressure in adults (18–85) with hypertension and readings over 150/95.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 85 Years |
| Sex | All |
| Enrollment | 1520 (estimated) |
| Sponsor | The Cleveland Clinic Academic / other |
| Locations | 1 site (Cleveland, Ohio) |
| Status | Recruiting |
| Started | January 6, 2026 |
| Main results expected | April 2029 |
| Study ends | July 2029 |
| Registry record updated | January 9, 2026 |
| Trial ID | NCT07232017 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18–85 with a diagnosis of hypertension and uncontrolled blood pressure (greater than 150/95) who are cared for in Cleveland Clinic Northeast Ohio primary care practices and are not pregnant, not in stage 5 CKD/ESRD, and not in hospice.
✕Probably not a fit
Patients who are pregnant, have stage 5 chronic kidney disease or end-stage renal disease, are enrolled in hospice, or whose blood pressure is already controlled (≤150/95) are not expected to benefit from this program.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Cleveland Clinic is scaling an intensive hypertension management program across 56 primary care practices in Northeast Ohio to reach roughly 3,800 patients over 48 months. The program expands team-based care—primary care providers working with pharmacists and advanced practice providers—to titrate blood pressure medicines using patient-recorded home blood pressure measurements. Implementation will include a 12-month pre-implementation phase with practice assessments, clinical decision support creation, staff training, and patient outreach planning. Quantitative outcomes will come from electronic medical records and surveys while qualitative methods (interviews, observations, reflections) will evaluate barriers and facilitators.
Why it matters
Potential benefit: If successful, the program could substantially increase the number of patients reaching blood pressure targets and lower their risk of heart attack and stroke.
How similar studies have gone: This program builds on prior randomized trial evidence (e.g., Margolis et al.) showing that pharmacist-led, home blood pressure–guided medication titration can improve blood pressure control.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Hypertension diagnosis, aged 18-85 years old * Uncontrolled blood pressure, defined as a blood pressure reading of \> 150/95 Exclusion Criteria: * pregnant, stage 5 chronic kidney disease, End Stage Renal Disease, enrolled in hospice care
Where it's running
-
Cleveland Clinic
Cleveland, Ohio, United States Recruiting
Study contacts
- Study coordinator: Anita Misra-Hebert, MD, MPH, FACP
- Email: MISRAA@ccf.org
- Phone: 216-445-8542
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.