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Clinical trials and research at Medical University of South Carolina

• 127Clinical trials
• 517NIH research projects
• 9Countries

Newest trials

All recruiting trials (127)

• Sex differences in how cannabis affects people who regularly use it

  This Phase 2 trial tests whether men and women who use cannabis several days a week respond differently to THC versus placebo.

  Recruiting Phase 2 Medical University of South Carolina · Charleston, South Carolina · NCT07815691

• taVNS added to oral motor training for babies with severe swallowing trouble

  This trial tests whether pairing a noninvasive taVNS treatment with oral sensorimotor training helps infants in NICUs swallow better and feed more safely.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07802301

• Personalized chemoimmunotherapy for early TNBC with high TILs (no anthracyclines upfront)

  This trial tests a 12-week, anthracycline-free neoadjuvant regimen of carboplatin, paclitaxel, and pembrolizumab in early-stage TNBC with high TILs to see if surgery outcomes are as good as historical regimens.

  Recruiting Phase 2 Medical University of South Carolina · Syracuse, New York and 1 other locations · NCT07743190

• Parietal brain stimulation for memory in Parkinson’s with mild cognitive impairment

  This study tests whether a short, high-dose burst of brain stimulation to the right superior parietal area can safely and feasibly help people with Parkinson’s-related cognitive impairment.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07701785

• Smell training plus non-invasive nerve stimulation to boost sense of smell

  This test will try adding non-invasive trigeminal nerve stimulation to standard smell training for adults with smell loss to see if it improves olfactory function.

  Recruiting Phase 2 Medical University of South Carolina · Charleston, South Carolina · NCT07689773

• Olfactory-focused low-intensity ultrasound on smell perception in healthy adults

  This study tests whether gentle, targeted ultrasound can change how healthy adults perceive odors and respond to them.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07658365

• Digitally Enhanced Stepped-Care for Depression in Primary Care

  A small pilot study tests whether using a self-guided Moodivate app first, with a possible switch to teletherapy if needed, helps adults with depression in primary care more effectively than teletherapy alone or Moodivate alone.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07634705

• At-home taVNS for Parkinson's disease

  This study tests whether at-home transcutaneous auricular vagus nerve stimulation (taVNS) can help people with Parkinson’s disease and whether it’s feasible to do this safely at home.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07536022

• Non-invasive brain stimulation plus computer-based memory training for mild cognitive impairment

  This trial will test whether a short course of non-invasive brain stimulation combined with one of two computer-based brain-training programs helps people aged 60–85 with mild cognitive impairment improve memory, thinking, mood, and daily function.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07526740

• At-home ear vagus nerve stimulation plus computer brain training for thinking and mood

  This study will try at-home transcutaneous auricular vagus nerve stimulation combined with computerized cognitive training to see if it helps people aged 45-80 with self-reported cognitive changes improve thinking and mood.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07517237

• Omitting postoperative radiation after HPV-related oropharyngeal cancer guided by ctHPVDNA monitoring

  This study tests whether some patients with HPV-related OPSCC can skip postoperative radiation after surgery if their tumors are low risk and ctHPVDNA looks negative.

  Recruiting Phase 2 Medical University of South Carolina · Charleston, South Carolina · NCT07513389

• Progesterone to Prevent Preeclampsia in Early Pregnancy

  This trial tests whether nightly vaginal progesterone started before 12 weeks can lower the chance of preeclampsia in low-risk pregnant people.

  Recruiting Phase 4 Medical University of South Carolina · Charleston, South Carolina · NCT07448597

• ZIDA Control Sock added to medication for overactive bladder with leakage

  This trial will try using the ZIDA Control Sock once a week at home for 12 weeks to see if adding it to your current medication reduces urgency urinary incontinence.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07432659

• Mailing buprenorphine after hospital discharge

  This pilot will test whether mailing buprenorphine to adults with opioid use disorder after medical hospitalization helps them stay in treatment.

  Recruiting Early Phase 1 Medical University of South Carolina · Charleston, South Carolina and 1 other locations · NCT07421102

• Direct (non-contact) laser versus standard selective laser for treating glaucoma

  This test compares a newer non-contact laser (DSLT) with the standard SLT to see if it lowers eye pressure just as well in adults with open-angle glaucoma or ocular hypertension.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07408154

• Accelerated brain stimulation for apathy in Parkinson's disease

  This pilot will see if an accelerated form of intermittent theta-burst brain stimulation can reduce apathy in people with Parkinson's disease.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07399496

• Behavioral health collaborative care for family members of ICU survivors in the Post-ICU clinic pilot

  This pilot tests a telehealth-based behavioral health program using the NeuroFlow app for family members of ICU survivors to try to reduce anxiety, depression, and PTSD symptoms.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07390786

• Behavioral health collaborative care for people recovering after ICU

  This trial will test whether a coordinated behavioral health program using a digital app, coaching, and psychiatric support helps ICU survivors reduce anxiety, depression, and PTSD symptoms.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07372586

• Mindfulness During Accelerated TMS for Depression

  This pilot tests whether short guided mindfulness practice used during aiTBS treatment for major depressive disorder is feasible, acceptable, and shows early signals of benefit.

  Recruiting Medical University of South Carolina · Charleston, South Carolina and 1 other locations · NCT07369557

• Hip exoskeleton to improve walking balance after stroke

  This trial will test whether a hip-worn exoskeleton can help people more than six months after a stroke improve their walking balance.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07356011

• Short-course pelvic radiotherapy with a focused high-dose microboost for high-risk prostate cancer

  This tests whether a shorter course of pelvic radiotherapy combined with a focused high-dose 'microboost' is safe and effective for men with previously untreated high-risk, very high-risk, or pelvic lymph node–positive prostate cancer.

  Recruiting Phase 2 Medical University of South Carolina · Charleston, South Carolina · NCT07325721

• Decision aid to help emergency department patients choose whether to start buprenorphine

  This project tests a short decision aid to help adults with moderate-to-severe opioid use disorder in the emergency department understand buprenorphine and decide whether to start it.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07278518

• SUPPORT-T palliative program for people with progressive pulmonary fibrosis and their caregivers

  This pilot tests a 9-week digital palliative care program plus quarterly virtual support groups to see if it helps adults with progressive pulmonary fibrosis and their caregivers.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07269262

• GLP‑1/GIP medications and stomach contents after fasting

  This check will see if adults taking GLP‑1 or GLP‑1/GIP medicines have more stomach contents than expected after standard fasting or a 24‑hour clear‑liquid diet before elective procedures.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07251803

• Personalized EEG‑guided brain stimulation during hand‑eye coordination

  We will try a personalized, EEG‑guided repetitive brain stimulation approach to improve hand‑eye force control in adults with upper limb sensorimotor impairment.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07249801

• Staged stereotactic radiosurgery versus fractionated stereotactic radiotherapy for larger brain metastases

  This trial tests whether staged stereotactic radiosurgery or fractionated stereotactic radiotherapy better controls brain metastases 2–5 cm in adults while reducing side effects.

  Recruiting Phase 2 Medical University of South Carolina · Charleston, South Carolina · NCT07227610

• Intraoperative methadone for pain control after total hip replacement

  This trial tests whether a single intraoperative IV dose of methadone lowers immediate postoperative pain and reduces opioid use in adults having elective total hip replacement with spinal anesthesia.

  Recruiting Phase 3 Medical University of South Carolina · Charleston, South Carolina · NCT07227064

• Single-dose IV methadone during knee replacement to lower pain and opioid use

  This trial will test whether one intraoperative IV dose of methadone reduces pain and the need for opioid pain pills after elective total knee replacement in adults.

  Recruiting Phase 3 Medical University of South Carolina · Charleston, South Carolina · NCT07226076

• Telehealth Parent–Child Interaction Therapy to strengthen relationships in at‑risk families

  This project will try Parent–Child Interaction Therapy delivered by video visits to help children ages 2–6 with behavior problems who are at risk from adverse childhood experiences.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07225010

• Reducing cannabis use to improve daily functioning.

  This program will try an 8-week combination of motivational interviewing, computerized CBT (CBT4CBT), and small financial rewards to help adults with cannabis use disorder cut back on cannabis.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07218471

• Remimazolam versus propofol for sedation during fractional CO₂ laser treatment of burn scars

  This will test whether remimazolam or propofol leads to fewer breathing problems and faster recovery for adults having fractional CO₂ laser treatment for burn scars.

  Recruiting Phase 4 Medical University of South Carolina · Charleston, South Carolina · NCT07213544

• Brain stimulation training to strengthen wrist extension after cervical spinal cord injury

  This study will test whether MEP up-conditioning using transcranial magnetic stimulation can help people with incomplete cervical spinal cord injury improve wrist extension.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07179822

• LiveWell: a tailored DBT skills program for people living with metastatic lung cancer

  This pilot randomized trial tests a telehealth DBT skills program called LiveWell for adults with metastatic non-small cell lung cancer and distress to see if it reduces distress and improves well-being compared to usual care.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07177846

• SPRINT peripheral nerve stimulation for chronic posterior sacroiliac joint (PSIJC) low back pain

  This study will try a temporary SPRINT peripheral nerve stimulator to see if it reduces chronic PSIJC-related lower back pain in adults who have already tried physical therapy and medications.

  Recruiting at 2 sites Medical University of South Carolina · Charleston, South Carolina and 1 other locations · NCT07166952

• Finding advanced liver fibrosis in MASLD patients during primary care visits

  This project will test an electronic health record alert that helps primary care teams identify MASLD patients at higher risk of advanced liver fibrosis so they can be referred for confirmatory testing.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07159386

• ICG dye imaging to help find head and neck tumors during surgery

  We will try a fluorescent dye called ICG during surgery to see if it helps surgeons find tumor tissue in adults with mucosal head and neck squamous cell cancer who are at risk of recurrence.

  Recruiting Phase 2 Medical University of South Carolina · Charleston, South Carolina · NCT07149207

• At-home ear neurostimulation for chronic post-stroke upper limb pain

  This study will try daily at-home ear nerve stimulation for people with chronic upper-arm pain after a stroke to see if it lowers their pain.

  Recruiting Medical University of South Carolina · Charleston, South Carolina and 1 other locations · NCT07144436

• Accelerated repetitive transcranial magnetic stimulation (rTMS) versus sham for post-stroke apathy

  This project will try a faster course of rTMS to see if it reduces persistent apathy in people at least six months after an ischemic or hemorrhagic stroke.

  Recruiting Phase 1/2 Medical University of South Carolina · Charleston, South Carolina · NCT07113067

• Nd:YAG laser to improve gum healing after tooth extraction and ridge preservation

  This test tries whether multiple Nd:YAG low-level laser sessions after tooth extraction and alveolar ridge preservation help adults heal faster and have less pain.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07095556

• Comparing NALIRIFOX to a modified gemcitabine/nab‑paclitaxel/cisplatin regimen for advanced pancreatic adenocarcinoma

  This compares NALIRIFOX to a modified gemcitabine/nab‑paclitaxel/cisplatin regimen to see if it helps people with untreated locally advanced or metastatic pancreatic ductal adenocarcinoma live longer or have better tumor responses.

  Recruiting at 2 sites Phase 2 Medical University of South Carolina · Charleston, South Carolina and 1 other locations · NCT07076212

• taVNS‑paired constraint therapy with sTMS screening for infants with one‑sided weakness

  This trial will test whether adding mild noninvasive vagus nerve stimulation to intensive one‑arm therapy helps infants 8–24 months with one‑sided weakness and whether a single brain stimulation pulse can predict who will benefit.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07063446

• Accelerated magnetic brain stimulation for seizure-type functional neurologic disorder

  This trial will try a shortened, intensified course of magnetic brain stimulation over the left frontal cortex to see if it reduces functional (non-epileptic) seizures in adults.

  Recruiting Early Phase 1 Medical University of South Carolina · Charleston, South Carolina · NCT07059325

• Combining rTMS and aerobic exercise to reduce depression and improve walking after stroke

  This study will try combining repetitive transcranial magnetic stimulation (rTMS) with treadmill aerobic exercise to see if it reduces depression and improves walking in people 12–60 months after a stroke.

  Recruiting at 2 sites Medical University of South Carolina · Durham, North Carolina and 1 other locations · NCT07050355

• BabyStrong II taVNS to help infants with feeding delays learn to feed

  This study tests whether twice-daily, gentle electrical stimulation of the vagus nerve at the ear (taVNS), with an added antioxidant (N‑acetylcysteine) for infants of diabetic mothers when appropriate, helps newborns and term infants with feeding delays reach full oral feeds faster than sham stimulation.

  Recruiting Phase 2/3 Medical University of South Carolina · Charleston, South Carolina · NCT07049952

• Social functioning and recovery for people with opioid use disorder

  This project will see if smartwatch data and daily surveys from people on buprenorphine and a close supporter can identify social behaviors linked to better treatment outcomes.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07044466

• Building physical capacity after chronic stroke

  This 12-week modified cardiac rehabilitation program will try to improve physical fitness and mood in people living with chronic stroke, including those with post-stroke depression.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07039305

• Formoterol for diabetic kidney disease

  This trial will test whether adding formoterol fumarate to usual care helps adults with type 2 diabetes who have moderate diabetic kidney disease.

  Recruiting Phase 2 Medical University of South Carolina · Charleston, South Carolina · NCT07022418

• Technology-enhanced therapy compared with medication monitoring to help pregnant people stay on buprenorphine

  This project will see if a short therapy program plus a mobile app helps pregnant people on buprenorphine stay on their medication better than medication monitoring.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06999811

• Exploring how deep brain stimulation affects attention and freezing of gait in Parkinson's disease

  This study tests how deep brain stimulation affects attention and helps reduce freezing of gait in people with Parkinson's disease.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06994728

• High-frequency nerve stimulation to reduce pain during IUD insertion

  This test checks whether high-frequency transcutaneous electrical nerve stimulation (hfTENS), a handheld non-drug device, reduces pain for adults having an IUD placed.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06991075

• Training to boost brain-to-spine signals for better wrist and hand control

  This trial will test whether 10 weeks of non-invasive brain stimulation with feedback can strengthen brain-to-spinal-cord signals and improve wrist and hand function in adults with chronic cervical spinal cord injury and weak wrist extension.

  Recruiting Early Phase 1 Medical University of South Carolina · Charleston, South Carolina · NCT06989905

• Personalized brain stimulation and walking exercises for freezing of gait in Parkinson's disease

  This study is testing if a mix of brain stimulation and walking exercises can help people with Parkinson's disease who struggle with freezing while walking.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06982638

• Autophagy maintenance with hydroxychloroquine, nelfinavir, and bevacizumab for platinum‑sensitive recurrent high‑grade serous ovarian cancer

  This trial will try giving two autophagy medicines (hydroxychloroquine and nelfinavir) together with maintenance bevacizumab to people with platinum‑sensitive first recurrent high‑grade serous ovarian, fallopian tube, or primary peritoneal cancer to see if it helps keep the cancer controlled.

  Recruiting Phase 2 Medical University of South Carolina · Charleston, South Carolina · NCT06971744

• Project Support for caregivers of children exposed to violence or maltreatment

  This trial tests whether a brief telehealth program called Project Support helps caregivers of 6–13-year-old children on a trauma-services waitlist improve parenting support and reduce family distress.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06963554

• How deep brain stimulation affects thinking and memory in Parkinson's

  This project will use MRI scans to see if subthalamic nucleus deep brain stimulation (DBS) changes brain networks and relates to thinking or memory declines in people with Parkinson's disease who already have DBS implants.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06960096

• Understanding how Deep Brain Stimulation affects Freezing of Gait in Parkinson's Disease

  This study is testing how Deep Brain Stimulation can help people with Parkinson's Disease who struggle with Freezing of Gait by looking at their brain and behavior before and after the treatment.

  Recruiting Phase 4 Medical University of South Carolina · Charleston, South Carolina · NCT06951906

• E-cigarettes versus nicotine patches and lozenges to help people in substance-use treatment quit smoking

  This trial will test whether switching completely to e-cigarettes helps adults in outpatient substance use treatment quit smoking compared with using nicotine patches and lozenges.

  Recruiting at 4 sites Medical University of South Carolina · Charleston, South Carolina and 3 other locations · NCT06922617

• Preoperative radiotherapy for soft tissue sarcoma

  This study tests if a shorter course of radiation therapy before surgery can help people with soft tissue sarcoma in their arms, legs, or trunk while protecting healthy tissue and reducing side effects.

  Recruiting Phase 2 Medical University of South Carolina · Charleston, South Carolina · NCT06905132

• Treatment for quitting cigarettes and reducing cannabis use

  This study tests if a medication called varenicline can help adults who smoke cigarettes and use cannabis quit smoking and cut down on cannabis use, with support from counseling and online resources.

  Recruiting Phase 3 Medical University of South Carolina · Charleston, South Carolina · NCT06883162

• Help for caregivers and children to speed emotional recovery after serious pediatric injury

  This project will test CAARE, a technology-assisted, stepped-care program, to help children under 12 hospitalized for serious injuries and their caregivers recover emotionally compared with enhanced usual care.

  Recruiting at 4 sites Medical University of South Carolina · Los Angeles, California and 3 other locations · NCT06856057

• Anthracycline-free pre-surgery chemoimmunotherapy for triple-negative breast cancer

  This 12–18 week treatment will test whether carboplatin, paclitaxel, and pembrolizumab before surgery can work for people with stage II–III triple-negative breast cancer who cannot receive anthracyclines because of heart problems.

  Recruiting Phase 2 Medical University of South Carolina · Charleston, South Carolina · NCT06845319

• REPOSE patient navigation to improve care for children with obstructive sleep apnea

  This project will try a centralized patient navigator to help families of children ages 2–11 with suspected sleep-disordered breathing get timely evaluation and treatment.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06828835

• Biologics in Chronic Rhinosinusitis With Nasal Polyps

  This study tests three biologic medicines to see which helps adults with chronic sinusitis and nasal polyps repayably improve symptoms and quality of life.

  Recruiting at 5 sites Phase 4 Medical University of South Carolina · Phoenix, Arizona and 4 other locations · NCT06824649

• Improving emotional recovery after stroke through therapy

  This study is testing if adding emotional support to regular therapy helps stroke survivors feel better and improve their daily lives.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06782321

• Mobile Transcranial Magnetic Stimulation for Depression

  This study is testing a new portable treatment for people with hard-to-treat depression to see if it can help them feel better while making it easier for them to access care.

  Recruiting Phase 4 Medical University of South Carolina · Charleston, South Carolina · NCT06748209

• Helping adults quit e-cigarettes while using cannabis

  This study is testing if a medication, along with financial rewards and counseling, can help adults aged 18-40 quit e-cigarettes while they also use cannabis.

  Recruiting at 3 sites Phase 4 Medical University of South Carolina · Charleston, South Carolina and 2 other locations · NCT06688539

• Evaluating nicotine pouches for quitting smoking

  This study is testing if tobacco-free nicotine pouches can help smokers switch from cigarettes by trying out different nicotine levels over 28 days.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06678789

• Therapy for Opioid Use Disorder and PTSD

  This study is testing a new therapy called HOPE to see if it helps people with both opioid use disorder and PTSD feel better when combined with their current medication.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06641115

• Injecting steroids to treat chronic cough

  This study is testing if steroid injections can help people with a long-lasting cough that doesn't have a clear cause feel better compared to a placebo.

  Recruiting Early Phase 1 Medical University of South Carolina · Charleston, South Carolina · NCT06634823

• Evaluation of a hospital violence intervention program

  This study is testing a program designed to help young people aged 16-35 who have experienced violence to see if it can reduce repeat injuries, improve their mental health, and enhance their overall hospital experience.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06582953

• Mobile app for treating depression in cancer survivors

  This study tests if a mobile app called 'Moodivate' can help cancer survivors who are feeling depressed feel better over 12 weeks.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06582784

• Investigating brain recovery in depression using MRI and TMS

  This study is testing how brain activity changes during TMS treatment for depression to see if it helps people feel better.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06562153

• Improving outcomes for chronic pain patients on long-term opioid therapy

  This study is testing three new ways to help people with chronic pain who are using long-term opioid therapy feel better and improve their quality of life.

  Recruiting Phase 1/2 Medical University of South Carolina · Charleston, South Carolina · NCT06442566

• Using ultrasound to create temporary visual disruptions for personalized brain stimulation

  This study is testing a new ultrasound technique to see how different levels of brain stimulation affect people's vision in healthy individuals.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06426498

• Using fingolimod to treat advanced lung cancers

  This study is testing if fingolimod can safely help people with advanced lung cancer who haven't improved with other treatments.

  Recruiting Phase 2 Medical University of South Carolina · Charleston, South Carolina · NCT06424067

• Comparing two pain management techniques for children undergoing palate surgery

  This study is testing two different pain management techniques for kids aged 6-18 who are having palate surgery to see which one helps them feel less pain after the operation.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06420336

• Using nerve stimulation to help premature infants breastfeed better

  This study is testing if a gentle nerve stimulation can help premature and sick term babies learn to breastfeed better while they're in the NICU.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06417385

• Intervention for cannabis use in young adults

  This study is testing two short programs to help young adults aged 18-25 who might be using cannabis too much, to see which one works better for them.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06395389

• Evaluating e-cigarettes versus traditional quit methods for smoking cessation

  This study is testing whether e-cigarettes can help smokers quit better than traditional methods like nicotine patches or medication.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06373679

• Comparing telehealth and in-person therapy for youth with PTSD in Puerto Rico

  This study tests whether therapy for PTSD delivered online works as well as in-person therapy for young people in Puerto Rico who have experienced trauma.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06332209

• Optimizing care for patients with acute ischemic stroke

  This study is testing different treatments for people who have had a stroke caused by blocked blood vessels to see which ones work best.

  Recruiting at 41 sites Medical University of South Carolina · Birmingham, Alabama and 40 other locations · NCT06289985

• Using focused ultrasound to help treat anxiety disorders

  This study is testing whether focused ultrasound can help people with anxiety by changing how their brain works during emotional tasks.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06273904

• Improving postpartum care for new mothers

  This study tests if a text message program can help new mothers in South Carolina get better postpartum care and catch health problems early compared to regular in-person visits.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06273436

• Understanding tobacco and cannabis use among young adults

  This study looks at how using cannabis affects young adults aged 18-25 who are trying to quit tobacco, while they receive support for their quit attempt over 12 weeks.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06239350

• Comparing weekly Isotretinoin to daily Tetracycline for moderate acne treatment

  This study is testing if taking Isotretinoin once a week works better than taking Doxycycline every day for treating moderate acne in people aged 12 and older.

  Recruiting Early Phase 1 Medical University of South Carolina · Charleston, South Carolina · NCT06225570

• Infusion of stem cells to reduce pain from chronic pancreatitis

  This study is testing whether infusing stem cells can help reduce pain for people suffering from chronic pancreatitis.

  Recruiting Early Phase 1 Medical University of South Carolina · Charleston, South Carolina · NCT06205342

• Smartphone behavioral sleep therapy for people starting buprenorphine for opioid use disorder

  This project will test a smartphone app that delivers cognitive behavioral therapy for insomnia and other sleep supports for adults beginning buprenorphine for opioid use disorder who have poor sleep.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06157840

• Short course of oral CBD before surgery for early-stage breast cancer

  This trial will test whether taking low or high dose oral CBD for 5 to 56 days before surgery affects primary invasive breast tumors in adults with Ki67 ≥ 10%.

  Recruiting Phase 1 Medical University of South Carolina · Charleston, South Carolina · NCT06148038

• Using different methods to help children feel less anxious during anesthesia induction

  This study tests different ways to help young children feel less anxious when they are getting ready for surgery with anesthesia.

  Recruiting Phase 4 Medical University of South Carolina · Charleston, South Carolina · NCT06144177

• Adaptive treatment for smokers struggling to quit

  This study is testing different ways to help smokers in Alabama and South Carolina quit by giving them free medications and adjusting their treatment based on how they're doing over 12 weeks.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06118502

• Web-based intervention for teens and young adults with sickle cell disease

  This study is testing a mobile app designed to help teens and young adults with sickle cell disease manage their symptoms and improve their overall health.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06035939

• Using brain stimulation to improve cognitive function and depression in older adults with mild cognitive impairment

  This study is testing if a special brain stimulation treatment can help older adults with mild cognitive impairment and depression feel better and think more clearly.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT05992831

• Exploring brain activity and emotional processing in healthy individuals and those with depression

  This study is trying to see how brain activity related to emotions works differently in healthy people and those with depression, to help find better treatments for emotional challenges.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT05977439

• Weight loss and exercise program for stroke survivors

  This study is testing a weight loss and exercise program to see if it can help stroke survivors who are overweight or obese improve their physical function and overall health.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT05901675

• Effects of menthol cigarette and e-cigarette regulations on smokers

  This study tests how rules about menthol cigarettes and e-cigarettes affect people who currently smoke menthols to see if it changes their smoking habits.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT05896033

• Exploring cannabis use and stress in young adults

  This study is testing how cannabis affects stress management in young adults with cannabis use disorder to see if a cannabidiol solution can help them cope better.

  Recruiting Phase 1/2 Medical University of South Carolina · Charleston, South Carolina · NCT05885542

• Improving smell function in long COVID patients through training and stimulation

  This study is testing two at-home treatments to see if they can help people with long COVID regain their sense of smell and possibly improve other symptoms.

  Recruiting Phase 2/3 Medical University of South Carolina · Charleston, South Carolina · NCT05855369

• Identifying brain biomarkers for cognitive decline after Deep Brain Stimulation in Parkinson's Disease

  This study is trying to find brain markers that can help predict how people with Parkinson's Disease will think and remember after getting Deep Brain Stimulation.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT05822388

• A program to support head and neck cancer survivors and their caregivers

  This study is testing a new support program for head and neck cancer survivors and their caregivers to see if it helps them manage symptoms and reduces stress compared to regular care.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT05811936

• Comparing navigation support to standard care for starting radiation therapy in head and neck cancer patients

  This study is testing a new support program to help people with head and neck cancer start their radiation therapy on time compared to the usual care they receive.

  Recruiting at 4 sites Medical University of South Carolina · St Louis, Missouri and 3 other locations · NCT05793151

• Exploring the link between alcohol misuse, PTSD, and intimate partner violence in couples

  This study is testing how alcohol misuse and PTSD affect violence between partners in couples to find better ways to prevent and treat these issues.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT05786157

• Testing a device feature to reduce interference in heart monitoring

  This study is testing a new feature in heart monitoring devices to see if it can better tell the difference between muscle movements and heart signals during arm exercises for people who already have an implanted device.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT05766943

• Evaluating an online program for quitting smoking in rural areas

  This study is testing an online program to help people in rural areas quit smoking and comparing it to regular care to see which works better.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT05764759

• Combining ear nerve stimulation and brain magnetic stimulation for depression treatment

  This study is testing if combining ear nerve stimulation with brain magnetic stimulation can help people with depression who haven’t found relief from regular medications.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT05725239

• Metabolically enhanced CAR T-cell therapy for relapsed B-cell cancers

  This study is testing a new way to improve CAR T-cell therapy for patients with relapsed B-cell cancers to see if it can work better and be safer.

  Recruiting Phase 1/2 Medical University of South Carolina · Charleston, South Carolina · NCT05702853

• Telehealth treatment for alcohol use disorder involving family support

  This study is testing a new telehealth program that includes family support to see if it helps Veterans with alcohol use disorder do better in treatment compared to standard care alone.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT05674409

• Investigating the effects of simvastatin on prostate cancer treatment

  This study is testing if taking simvastatin for eight weeks before prostate surgery can help boost the immune response in men recently diagnosed with localized prostate cancer.

  Recruiting Phase 2 Medical University of South Carolina · Atlanta, Georgia and 1 other locations · NCT05586360

• Improving access to mental health services after traumatic injury

  This study is testing a new program that helps people recover mentally after a traumatic injury to see if it works better than standard care.

  Recruiting Medical University of South Carolina · Washington, Virginia · NCT05497115

• Improving smoking cessation through telehealth in primary care

  This study is testing if an online visit can help people quit smoking better than regular care by offering support and possibly medication.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT05493254

• Training leg reflexes to reduce neuropathic pain after spinal cord injury

  This study is testing whether training leg reflexes can help reduce neuropathic pain in people with spinal cord injuries.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT05492188

• Testing a new method to relieve pain using nerve stimulation and naloxone

  This study is testing a new way to relieve pain using nerve stimulation and a medication called naloxone to see if it helps people feel better without relying on opioids.

  Recruiting Early Phase 1 Medical University of South Carolina · Charleston, South Carolina · NCT05490134

• Using auricular stimulation to assess pain relief effects during MRI

  This study is testing if a new way of stimulating certain nerves in the ear can help relieve pain during MRI scans for people with chronic pain.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT05487664

• A program to help teens reduce cannabis and alcohol use

  This study is testing a new computer program to help teens aged 13-17 cut down on their use of cannabis and alcohol.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT05486234

• Improving body image for head and neck cancer survivors

  This study is testing a new video therapy program to see if it can help head and neck cancer survivors feel better about their body image and improve their overall well-being.

  Recruiting at 5 sites Medical University of South Carolina · Detroit, Michigan and 4 other locations · NCT05442957

• Training wrist muscle responses in people with incomplete spinal cord injuries

  This study is testing whether targeted training can improve wrist movement in people with incomplete spinal cord injuries by strengthening the connection between their brain and muscles.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT05321017

• Training system to improve spinal reflexes in individuals with spinal cord injuries

  This study is testing a new training system to see if it can help people with spinal cord injuries reduce leg stiffness and improve their movement.

  Recruiting Medical University of South Carolina · Charleston, South Carolina and 1 other locations · NCT05094362

• Combination therapy for advanced solid tumors and prostate cancer

  This study is testing a new combination of five oral drugs to see if they can safely help people with advanced solid tumors and prostate cancer.

  Recruiting Phase 1/2 Medical University of South Carolina · Charleston, South Carolina · NCT05036226

• Improving smoking cessation support for people living with HIV

  This study is testing a new way of helping people with HIV quit smoking by comparing regular support to a more proactive approach to see which one works better.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT05019495

• Using brain stimulation to reduce alcohol cravings

  This study is testing if a type of brain stimulation can help people with alcohol use disorder reduce their cravings and drinking behavior.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT04998916

• Registry for patients undergoing surgery for brain injuries

  This study collects information from patients having surgery for brain injuries to see how different treatments work and to help improve care for future patients.

  Recruiting at 63 sites Medical University of South Carolina · Birmingham, Alabama and 62 other locations · NCT04994756

• Using brain stimulation to help people quit smoking

  This study is testing if a special brain treatment can help people quit smoking by focusing on specific areas of the brain that are linked to tobacco addiction.

  Recruiting at 2 sites Medical University of South Carolina · Charleston, South Carolina and 1 other locations · NCT04903028

• Weekly treatment with sirolimus for venous and lymphatic malformations

  This study is testing if giving sirolimus once a week can help people with venous and lymphatic malformations feel better while causing fewer side effects than taking it every day.

  Recruiting Phase 2 Medical University of South Carolina · Charleston, South Carolina · NCT04861064

• Using a device to change how people cope with anxiety

  This study is testing if a device that uses magnetic pulses can help people with anxiety learn to cope better with their feelings.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT04824105

• Treatment for depression in individuals with spinal cord injuries

  This study is testing if a new treatment called rTMS can help people with spinal cord injuries who are also dealing with depression feel better.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT04263285

• Accelerated theta burst treatment for postpartum depression

  This study is testing a new treatment using brain stimulation for women with postpartum depression to see if shorter sessions can help them feel better.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT03417960

• Evaluating cardiac imaging techniques for heart diseases

  This study is testing new heart imaging techniques to see if they can help doctors better diagnose and treat people with different heart diseases.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT02855554

• Understanding systemic lupus erythematosus in the Gullah population

  This study is trying to learn more about systemic lupus erythematosus in the Gullah community to better understand how genetics and the environment affect this disease.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT00756769

NIH-funded research (newest 40 of 517)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Il1rapl2’s role in shaping cortical wiring in autism

  This project studies how a brain gene linked to autism helps form the connections in deep-layer neurons to understand why circuits develop differently in ASD.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11686533

• Neuron-OPC Synaptic Mechanisms Shaping Myelin in Health and Disease

  This project looks at how brain cells called oligodendrocyte precursor cells (OPCs) listen to neurons to shape myelin, with potential relevance for autism and related conditions.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11686448

• Synaptic development and sleep-related brain circuits in autism

  A study in mice explores how early brain circuits that help sleep become wired, hoping to understand sleep problems in autism.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11686419

• Enteric neuron and intestinal stem cell signals shaping gut barrier

  A research project from the Medical University of South Carolina explores how nerve cells in the gut talk to the lining and stem cells to defend the digestive tract, using human organoids and mouse models.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11623911

• Glutamine and macrophage behavior in liver cancer

  A funded project at a medical university aims to understand how the liver’s immune cells interact with a specific type of liver cancer by looking at metabolism, especially glutamine and ammonia.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11623910

• Glycoprotein urine markers that signal lupus nephritis treatment response

  A novel test uses urine glycoprotein patterns to show how well lupus nephritis is responding to standard treatment.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11550186

• NCORP Community Site expands access to cancer trials

  A NCORP community site at MUSC/Hollings Cancer Center is working to include more medically underserved patients in cancer trials and improve how trials are recruited, retained, and delivered in the community.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11543489

• Tumor vulnerability from losing a cluster of metal-binding genes in cancer

  Researchers are studying how losing a group of metal-binding genes makes some cancers more vulnerable, with potential clues for new treatments.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11541958

• Social stress and smoking: why disadvantaged young adults struggle to quit

  This grant looks at how daily social stress affects if and when disadvantaged young adults who smoke can quit and stay quit.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11540695

• Autism and Self-regulation: Remote Testing of Heart-Related Signals in Kids

  A study to see if remote testing can safely measure how children with autism and disruptive behavior manage emotions and self-control by tracking heart signals and other markers.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11540693

• Targeting aging cells to help TMJ arthritis

  A new approach aims to selectively remove aging p21-high cells in the jaw joint to reduce degeneration and pain in people with TMJ problems.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11538354

• Notch signaling in TMJ osteoarthritis: uncovering mechanisms and new targets

  Researchers are studying how Notch signaling affects TMJ osteoarthritis to identify new ways to protect and repair the jaw joint.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11522770

• How RNA Splicing Might Shape Glioma Cell States and Therapy Response

  A small NIH-funded project will study how alternative RNA splicing influences glioma cell identities and treatment resistance in patient-derived cells.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11509415

• Molecular factors behind aggressive inflammatory breast cancer in African Ancestry women

  This project studies why inflammatory breast cancer is more deadly and happens earlier in African Ancestry women, with the aim of finding ways to improve outcomes.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11471093

• Sequential treatment additions to help long-term opioid therapy patients feel better

  A multi-step approach tests adding low-dose buprenorphine, cognitive behavioral therapy, and brain stimulation to improve pain and quality of life for people on long-term opioid therapy without forcing a taper.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11454727

• Digital toolkit to improve IPV screening and care in opioid use disorder

  A digital toolkit helps clinics screen for intimate partner violence and connect people with IPV-related care for those being treated for opioid use disorder.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11454644

• Understanding spinal pain pathways in people with SCI

  This study looks at how spinal cord injury changes the way pain signals are processed, with the goal of developing better ways to relieve neuropathic pain.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11454486

• Targeting C3 Activation to Protect Kids’ Brain Development After Early Mild TBIs

  Aims to understand how a specific immune signal (C3) affects brain wiring after early mild brain injuries in children and whether blocking it helps prevent long-term problems.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11449593

• Dysarthria treatment in Parkinson’s patients: real-world use, barriers, and outcomes

  A real-world study to understand how speech therapy for Parkinson’s-related dysarthria works for patients, families, and clinicians in everyday clinical settings.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11448207

• Varenicline for Cannabis Use Disorder in Men and Women

  A clinical trial will test if varenicline helps people with cannabis use disorder, with a focus on differences between men and women and added counseling to support craving and mood management.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11445421

• Alzheimer's disease and cancer immunity: how mitochondrial lipids in T-cells affect aging-related cancer control

  This grant explores how changes in mitochondria and lipid metabolism in T-cells of people with Alzheimer's disease might boost or hinder cancer immunity as we age.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11441839

• Improving engagement in post-injury mental health care with community health workers

  A patient-friendly look at a program that uses community health workers to help trauma survivors stay engaged with mental health care after injuries like gunshot wounds or car crashes.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11435930

• HSP70: a targeted therapy approach for pancreatic cancer

  A new treatment approach aims to disable a cancer-specific protein, potentially helping people with pancreatic cancer who have limited options.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11432388

• N-acetylcysteine to rebalance brain chemistry and reduce heavy drinking in bipolar disorder with alcohol use

  This project tests a safe medication, N-acetylcysteine, to help people with bipolar disorder who drink heavily by stabilizing brain chemistry and reducing drinking.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11430386

• Single-cell multi-omics platform for immune cells (PD- CAR-T related)

  A new single-cell analysis platform is being developed to map thousands of immune cells, including CAR-T cells from cancer patients, by analyzing multiple molecular features at once.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11429710

• Reducing and Preventing Retained Surgical Items (RFOs)

  A patient-facing look at a project that aims to reduce retained surgical items by studying and improving how surgical counts and teamwork work in operating rooms.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11421132

• Pediatric cooling duration to improve brain outcomes after cardiac arrest

  This project tests whether different durations of cooling after a child’s cardiac arrest can lead to better brain recovery.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11420478

• TBK1 and the immune system in cancer: boosting how the body attacks tumors

  A study to understand how TBK1 in tumor and immune cells affects cancer immunotherapy and whether blocking TBK1 can help patients respond better to treatment.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11418513

• Multifaceted intervention to improve graft outcome disparities in African American kidney transplants

  Aims to reduce higher graft loss in African American kidney transplant recipients by using a technology-enabled plan to better manage blood pressure, diabetes, and medication adherence.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11416794

• Neuro-PRECISE Center: Community Engagement & Outreach Core

  A patient-facing core that helps researchers and clinicians involve people with lived experience and their support networks in all center activities.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11413425

• Neural-Precision Neurorehabilitation Center: Core Research Program

  A large NIH grant aims to build tools and methods to precisely identify and modulate brain circuits to improve rehabilitation outcomes for people with CNS injuries.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11413417

• Neural Circuits Resource Center for Precision Neurorehabilitation

  A center that helps researchers study and modulate brain circuits to improve rehabilitation for people with CNS injuries.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11413413

• Center to Improve Precision Neurorehabilitation through Community Voices

  A national center project aims to actively involve people with lived experience and caregivers to shape brain- injury rehabilitation research and share findings widely.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11413409

• Pilot test of a telehealth-based approach to improve child maltreatment prevention reach and quality

  A pilot project will test a telehealth-enabled approach to help more families access high-quality, safe child maltreatment prevention services.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11412405

• mF2F Program: Digital tools to improve quality of life for Black men after trauma

  A digitized version of an evidence-based program aims to reduce stress, boost mental well-being, and encourage healthy habits for Black men.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11412404

• Smartphone app to support women with PTSD and substance use after sexual assault

  A smartphone app will help deliver an integrated PTSD and substance-use program for sexual assault survivors, aiming to make it easier to get evidence-based support.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11412403

• Dissemination and Implementation Science for Trauma Care and Resilience

  A patient-friendly look at a program that aims to speed up and improve how trauma care and resilience services are used in communities that need them most.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11412402

• Community Engagement Core for BRIGHT COBRE (Trauma-affected Communities)

  A centralized hub that helps BRIGHT researchers build real partnerships with trauma-affected communities to improve health outcomes.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11412401

• Digital Health Core for trauma care patients

  A digital health support hub is being created to help researchers develop and test digital tools that improve access, quality, and outcomes for trauma-affected and underserved patients.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11412400

• Administrative Core for a trauma-focused research center at MUSC

  A center-wide administrative core at MUSC will guide a multidisciplinary program to improve care for people affected by trauma through technology-enabled, stakeholder-engaged research.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11412398

Quick answers

How many clinical trials run by Medical University of South Carolina are recruiting right now?

127, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in United States (127 trials), Canada (1 trial), Germany (1 trial), Japan (1 trial), Portugal (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 15, Early Phase 1: 7, Phase 4: 7, Phase 1/2: 5. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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