Multifaceted intervention to improve graft outcome disparities in African American kidney transplants
Official title: Multifaceted Intervention to Improve Graft Outcome Disparities in African American Kidney Transplants (MITIGAAT)
Funded at Medical University of South Carolina · NIH-11416794 · Data updated 2026-11-12
Aims to reduce higher graft loss in African American kidney transplant recipients by using a technology-enabled plan to better manage blood pressure, diabetes, and medication adherence.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project start | July 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $620,738 |
| NIH project number | 5R01DK134326-04 |
| Project ID | NIH-11416794 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults who have received an African American kidney transplant and are at risk for late graft loss or suboptimal hypertension/diabetes control.
✕Less likely to help
Patients without post-transplant hypertension or diabetes or those not experiencing late post-transplant challenges may see limited benefit.
What this research studies
This grant focuses on helping African American kidney transplant patients achieve better long-term graft success through a technology-enabled intervention that targets blood pressure and diabetes control and tracks medication adherence. The team has already completed a pilot study and two randomized trials showing real-time medication monitoring is feasible and acceptable, with promising improvements in hypertension control among African American participants. The MITIGAAT study will test a multifaceted approach to reduce late post-transplant complications and late rejection by improving ongoing medical management and monitoring after transplant. If successful, the intervention could lead to fewer graft losses and better quality of life for African American kidney transplant patients.
Why it matters
Potential benefit: If successful, patients could experience longer-lasting kidney grafts and improved blood pressure and diabetes management.
How similar studies have gone: Prior studies showed feasible real-time adherence monitoring and promising improvements in hypertension control, supporting the potential of this approach.
Where this research is happening
-
Medical University of South Carolina
Charleston, United States Active
Researchers
- Principal investigator: Mcgillicuddy, John W. — Medical University of South Carolina
- Study coordinator: Mcgillicuddy, John W.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.