Molecular factors behind aggressive inflammatory breast cancer in African Ancestry women
Official title: Molecular Determinants of Inflammatory Breast Cancer
Funded at Medical University of South Carolina · NIH-11471093 · Data updated 2026-11-12
This project studies why inflammatory breast cancer is more deadly and happens earlier in African Ancestry women, with the aim of finding ways to improve outcomes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project start | September 20, 2021 |
| Project end | July 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $615,910 |
| NIH project number | 7R01CA264529-06 |
| Project ID | NIH-11471093 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are patients with inflammatory breast cancer, especially those of African Ancestry, contributing tumor samples or clinical data.
✕Less likely to help
Patients without IBC or those not matching the study’s focus or available samples may not benefit.
What this research studies
The study focuses on the biology of inflammatory breast cancer (IBC), which disproportionately affects African Ancestry women. Researchers will explore tumor mechanisms and how adaptive stress responses may drive aggressiveness, with epidemiological work linking risk factors like reproductive history and BMI to worse outcomes. The team plans to connect laboratory findings to potential therapeutic strategies that could reduce disparities in survival. Participation may involve analysis of tumor samples and patient data to understand differences between groups, with the goal of informing targeted treatments in the future.
Why it matters
Potential benefit: If successful, findings could lead to new therapies that lessen the impact of IBC in African Ancestry women and reduce survival gaps.
How similar studies have gone: Prior research has identified health disparities in IBC; this study builds on emerging evidence linking biology and risk factors to outcomes.
Where this research is happening
-
Medical University of South Carolina
Charleston, United States Active
Researchers
- Principal investigator: Devi, Gayathri — Medical University of South Carolina
- Study coordinator: Devi, Gayathri
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.