Direct (non-contact) laser versus standard selective laser for treating glaucoma

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with open-angle glaucoma or ocular hypertension are randomly assigned to receive either direct selective laser trabeculoplasty (DSLT), a newer non-contact approach, or standard selective laser trabeculoplasty (SLT). Both are FDA-approved laser treatments that aim to lower intraocular pressure and slow vision loss, and participants are followed for 12 months with regular eye-pressure checks and safety monitoring. Primary outcomes include changes in intraocular pressure and treatment-related adverse events, with additional measures of treatment comfort and efficiency. The trial is designed as a noninferiority comparison to determine whether DSLT performs at least as well as standard SLT.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years
* Diagnosis of OAG (including exfoliative or pigmentary) or OHT
* Gonioscopically open angle (visible scleral spur 360°)
* Ability to consent and comply with follow-up

Exclusion Criteria:

* Angle-closure or secondary glaucomas
* IOP \>35 mmHg despite therapy
* Corneal pathology interfering with laser or IOP measurement
* Recent ocular surgery (\<6 months)
* Contraindications to study medications or procedures
* Cognitive impairment preventing consent

Where it's running

• Musc
  Charleston, South Carolina, United States Recruiting

Study contacts

• Principal investigator: Jella An, MD — Medical University of South Carolina

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.