Single-dose IV methadone during knee replacement to lower pain and opioid use

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a randomized, double-blind, placebo-controlled Phase 3 trial enrolling adults having elective primary total knee arthroplasty under spinal anesthesia with mepivacaine. Participants receive a single intraoperative IV dose of methadone (0.15 mg/kg based on ideal body weight) or placebo, with standard perioperative care otherwise. The study measures acute postoperative pain levels and total opioid consumption after surgery. The trial is conducted at the Medical University of South Carolina and is limited to English-speaking participants able to provide written consent.

Why it matters

Who can join: the full rules

Inclusion

* Ages 18-75 years of age
* Undergoing elective primary total knee arthroplasty with mepivacaine in the spinal anesthesia

Exclusion

* Allergy to methadone or mepivacaine
* Severe liver disease defined as Child's Pugh Class C
* End stage renal disease requiring dialysis
* Known diagnosis of prolonged QT syndrome
* Currently pregnant
* Unable to provide written, informed consent
* Non-English speaking

Where it's running

• Medical University of South Carolina
  Charleston, South Carolina, United States Recruiting

Study contacts

• Principal investigator: William Barrett, M.D. — Medical University of South Carolina
• Study coordinator: Haley Nitchie, MHA
• Email: nitchie@musc.edu
• Phone: 843-792-1869

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.