Olfactory-focused low-intensity ultrasound on smell perception in healthy adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This exploratory study uses a within-subject, randomized, sham-controlled crossover design to apply low-intensity transcranial focused ultrasound to the amygdala and ventral striatal olfactory tubercle. Participants experience both sham and active stimulation, with outcomes including subjective odor valence ratings and objective neurophysiological and behavioral measures. The goal is to understand causal effects on odor processing in healthy volunteers, not to evaluate safety or clinical efficacy. The study incorporates EEG, MRI, and standardized odor tasks to characterize mechanistic changes in odor-evoked responses.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18-65 years
* Healthy adult volunteers
* Normal olfactory function (Sniffin' Sticks total TDI ≥ 30.75)
* Ability to provide informed consent
* English fluency sufficient for task completion

Exclusion Criteria:

* MRI or tFUS contraindications (e.g., metal implants, claustrophobia, pregnancy)
* Sinonasal conditions affecting airflow or smell
* Current use of medications that alter olfaction
* Positive urine drug screen

Where it's running

• Medical University of South Carolina
  Charleston, South Carolina, United States Recruiting

Study contacts

• Study coordinator: Nicole Cash, Study Coordinator
• Email: cashni@musc.edu
• Phone: 843-790-3449

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.