Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Nd:YAG laser to improve gum healing after tooth extraction and ridge preservation

Official title: Impact of Nd: YAG Laser Photobiostimulation on Healing of Gingiva Following Tooth Extraction and Alveolar Ridge Preservation

Run by Medical University of South Carolina · NCT07095556 · Data updated 2026-11-12

This test tries whether multiple Nd:YAG low-level laser sessions after tooth extraction and alveolar ridge preservation help adults heal faster and have less pain.

More Wound Healing trials

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment39 (estimated)
SponsorMedical University of South Carolina
Academic / other
Locations1 site (Charleston, South Carolina)
StatusRecruiting
StartedNovember 5, 2025
Main results expectedDecember 2026
Study endsApril 30, 2027
Registry record updatedNovember 12, 2025
Trial IDNCT07095556 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults (≥18) scheduled for tooth extraction and alveolar ridge preservation who can report pain and have no contraindications such as active infection, untreated periodontal disease, recent antibiotic use, pregnancy, lactation, bisphosphonate therapy, or intraoperative alveolar bone defects.

Probably not a fit

Patients with active dental infection, untreated periodontal disease, recent antibiotics, bisphosphonate use, detected alveolar bone defects, or who are pregnant or breastfeeding are unlikely to qualify or benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults scheduled for tooth extraction and alveolar ridge preservation will receive either standard care or standard care plus Nd:YAG photobiostimulation applied on days 1, 3, and 7 after the procedure. Investigators will follow healing by measuring salivary biomarkers, gingival wound size, reported pain medication use, and patient satisfaction. The intervention uses low-level laser therapy intended to reduce inflammation and stimulate cellular repair in the socket and surrounding gingiva. The trial is conducted at the MUSC College of Dental Medicine Graduate Periodontics Clinic in Charleston, South Carolina.

Why it matters

Potential benefit: If successful, the laser could speed gingival healing, reduce post-operative pain, and improve comfort and readiness for implant placement.

How similar studies have gone: Previous studies of low-level laser therapy in oral wound healing have shown promising but mixed results, so the approach is suggestive but not yet definitively proven.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Participants who are ≥ 18 years old,
* Patients who are scheduled for the treatment of tooth extraction and alveolar ridge preservation (ARP)
* No contraindications for tooth extraction and alveolar ridge preservation based on electronic health records.
* Participants who can express the level of pain
* Participants who self-report "not pregnant"

Exclusion Criteria:

* Untreated periodontal disease
* Acute infection of the teeth
* Use of antibiotics within the last three months.
* Pregnant or lactating women
* Use of bisphosphonates based on EHR
* Alveolar bone defects occurred or were detected during tooth extraction

Where it's running

  • MUSC College of Dental Medicine, Graduate Periodontics Clinic
    Charleston, South Carolina, United States
    Recruiting

Study contacts

  • Principal investigator: Pinar Emecen-Huja — Medical University of South Carolina
  • Study coordinator: Pinar Emecen-Huja
  • Email: emecenh@musc.edu
  • Phone: (843) 792-5688

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.