Reducing cannabis use to improve daily functioning.
Prospective Changes in Patient-reported and Objective Functioning Following Reduction of Cannabis Use
This program will try an 8-week combination of motivational interviewing, computerized CBT (CBT4CBT), and small financial rewards to help adults with cannabis use disorder cut back on cannabis.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 176 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Medical University of South Carolina Academic / other |
| Locations | 1 site (Charleston, South Carolina) |
| Trial ID | NCT07218471 on ClinicalTrials.gov |
What this trial studies
Adults diagnosed with DSM-5 cannabis use disorder who have a baseline urinary cannabinoid level ≥50 ng/mL will take part in an 8-week intervention combining motivational interviewing, computerized cognitive behavioral therapy (CBT4CBT), and contingency management with financial incentives tied to reduced urinary cannabinoids. Participants will provide urine samples to document change in cannabinoid levels and complete measures of cannabis-related problems, sleep, cognitive performance, CUD severity, and quality of life. The protocol requires an intake visit and excludes people with serious medical or psychiatric conditions, pregnancy or breastfeeding, or those using cannabis solely for medical purposes. The study is conducted at the Medical University of South Carolina and uses objective biologic testing alongside behavioral treatment modules.
Who should consider this trial
Good fit: Adults (18+) with a DSM-5 diagnosis of cannabis use disorder, a baseline urinary cannabinoid level ≥50 ng/mL, and willingness to try reducing cannabis are the intended participants.
Not a fit: People who are pregnant or breastfeeding, have serious medical or psychiatric conditions that could worsen with reduction, use cannabis only for medical reasons, or cannot complete consent or study procedures may not benefit from this program.
Why it matters
Potential benefit: If successful, the approach could help people reduce cannabis use and improve sleep, thinking, and overall quality of life.
How similar studies have performed: Previous studies using motivational interviewing, computerized CBT, and contingency management have shown benefits for substance use disorders and some success in reducing cannabis use.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18+ * Urinary cannabinoid level ≥ 50 ng/mL * DSM-5 diagnosis of CUD (mild, moderate, or severe) * Willingness to attempt cannabis reduction * Completion of Intake Visit Exclusion Criteria: * Serious medical/psychiatric conditions * Pregnancy or breastfeeding * Use of cannabis in past 30 days was for medical purposes only * Discontinuation or reduction of cannabis use may exacerbate a pre-existing condition * Cognitive or understanding difficulties, as evidenced by inability to pass informed consent quiz
Where this trial is running
Charleston, South Carolina
- Medical University of South Carolina — Charleston, South Carolina, United States (Recruiting)
Study contacts
- Principal investigator: Rachel Tomko, PhD. — Medical University of South Carolina
- Study coordinator: Rachel Tomko, PhD
- Email: tomko@musc.edu
- Phone: (843) 792-5447
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.