Helping adults quit e-cigarettes while using cannabis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effectiveness of varenicline, a medication typically used for cigarette cessation, combined with financial incentives and counseling for adults aged 18-40 who co-use e-cigarettes and cannabis. Participants will receive treatment for 12 weeks while their tobacco cessation outcomes are monitored, particularly focusing on how cannabis use affects these outcomes. The study seeks to fill a gap in understanding the interaction between cannabis and tobacco during quit attempts, as current literature lacks consensus on treatment recommendations for this population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Between the ages of 18 and 40 years old
* Use e-cigarettes daily or near daily in the past month
* Must submit a positive instant-read urine cotinine test at screening (≥ 200 ng/ml)
* Be interested in quitting use of e-cigarettes
* Must be willing to take varenicline for the standard 12-week course of treatment
* Self-reported use of cannabis on at least 10 out of the past 30 days or must submit a positive qualitative urinary cannabinoid test at screening (\> 50 ng/ml)

Exclusion Criteria:

* Any serious or unstable medical/psychiatric disorder (including severe substance use disorders, other than cannabis or tobacco use disorders) in the past three months that may interfere with study performance
* Use of cigarettes on 10+ days in the past 30
* Currently pregnant or breastfeeding
* Current use of medications with smoking cessation efficacy
* Use of any medications that would interfere with varenicline

Where it's running

• MUSC Charleston
  Charleston, South Carolina, United States Recruiting
• MUSC Lancaster
  Lancaster, South Carolina, United States Recruiting
• Behavioral Health Services of Pickens County
  Pickens, South Carolina, United States Recruiting

Study contacts

• Principal investigator: Erin A McClure, PhD — Medical University of South Carolina
• Study coordinator: Elizabeth Chapman, MA, LPC, LAC, AADC
• Email: chapmanb@musc.edu
• Phone: 864.898.2992

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• tDCS plus varenicline to help people quit smoking

  This will test if adding noninvasive tDCS brain stimulation to varenicline helps adults who smoke at least 8 cigarettes a day quit and stay smoke-free.

  Recruiting Phase 4 Centre for Addiction and Mental Health · Toronto, Ontario · NCT06798324

• Deep TMS to help adults with psychiatric conditions quit smoking

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  Recruiting Phase 4 Centre for Addiction and Mental Health · Toronto, Ontario · NCT06534047

• Understanding tobacco and cannabis use among young adults

  This study looks at how using cannabis affects young adults aged 18-25 who are trying to quit tobacco, while they receive support for their quit attempt over 12 weeks.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06239350

• Investigating the effects of propranolol and nicotine patches on smoking cues

  This study is testing whether taking propranolol and using nicotine patches can help daily smokers resist the urge to smoke when they see things that remind them of smoking.

  Recruiting Phase 4 University of Oklahoma · Tulsa, Oklahoma · NCT05587361

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.