Web-based intervention for teens and young adults with sickle cell disease

Self-Management for Youth Living With Sickle Cell Disease: SMYLS Multi-site Trial

NA · Medical University of South Carolina · NCT06035939

This study is testing a mobile app designed to help teens and young adults with sickle cell disease manage their symptoms and improve their overall health.

Quick facts

PhaseNA
Study typeInterventional
Enrollment272 (estimated)
Ages14 Years to 21 Years
SexAll
SponsorMedical University of South Carolina (other)
Locations1 site (Charleston, South Carolina)
Trial IDNCT06035939 on ClinicalTrials.gov

What this trial studies

This study tests the effectiveness of SMYLS, a mobile health intervention aimed at helping adolescents and young adults with sickle cell disease manage their symptoms and improve self-management behaviors. The intervention includes a mobile app that provides educational materials and a voice crisis alert system. Researchers will evaluate its impact on self-management, quality of life, transition readiness, healthcare utilization, and pain interference, while also exploring factors that influence patient activation and self-management outcomes.

Who should consider this trial

Good fit: Ideal candidates are adolescents and young adults with a documented diagnosis of sickle cell disease who have access to a compatible mobile device and the internet.

Not a fit: Patients who are planning to transition to adult care within the next 12 months or those with neurocognitive impairments that hinder their ability to use the intervention may not benefit from this study.

Why it matters

Potential benefit: If successful, this intervention could significantly enhance self-management skills and overall quality of life for patients with sickle cell disease.

How similar studies have performed: While there have been studies exploring mobile health interventions for chronic conditions, this specific approach targeting self-management in sickle cell disease is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* documentation in the electronic health record of any type of SCD
* owns mobile device compatible with the intervention
* access to the internet

Exclusion Criteria:

* Plans to relocate outside of study site area in the next 12 months
* Plans to transition to adult care in 12 months or less
* Parent/caregiver or provider report of neurocognitive impairment that precludes ability to use intervention and participate in study
* non-English speaking

Where this trial is running

Charleston, South Carolina

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Sickle Cell Disease

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.