Identifying brain biomarkers for cognitive decline after Deep Brain Stimulation in Parkinson's Disease
Official title: A Neural Basis for Cognitive Decline Following Deep Brain Stimulation
Run by Medical University of South Carolina · NCT05822388 · Data updated 2026-11-12
This study is trying to find brain markers that can help predict how people with Parkinson's Disease will think and remember after getting Deep Brain Stimulation.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 80 (estimated) |
| Sponsor | Medical University of South Carolina Academic / other |
| Locations | 1 site (Charleston, South Carolina) |
| Status | Recruiting |
| Started | April 1, 2023 |
| Main results expected | March 31, 2027 |
| Study ends | March 31, 2027 |
| Registry record updated | May 29, 2026 |
| Trial ID | NCT05822388 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults over 18 years old who are planning to undergo DBS surgery for Parkinson's Disease.
✕Probably not a fit
Patients with uncorrected visual or hearing impairments, claustrophobia, or those with non-MRI compatible implants may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This research aims to identify MRI-based brain biomarkers that predict how individuals with Parkinson's Disease respond to Deep Brain Stimulation (DBS) and to assess cognitive changes associated with the procedure. A total of 55 participants with Parkinson's Disease, who are scheduled for DBS, will undergo a series of visits including screening, MRI scanning, and cognitive assessments. Additionally, control participants without Parkinson's Disease will also be recruited for comparative MRI and cognitive evaluations. The study seeks to understand factors contributing to cognitive decline post-DBS, which could enhance patient selection and optimize stimulation targets.
Why it matters
Potential benefit: If successful, this study could lead to improved patient selection for DBS surgery and strategies to minimize cognitive side effects.
How similar studies have gone: While there is existing research on DBS and cognitive outcomes, this specific approach focusing on MRI biomarkers is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
PD Participants Inclusion Criteria: * Subjects above 18 years of age * Subjects who will undergo DBS surgery as part of their clinical care for PD Exclusion Criteria: * Uncorrected visual or hearing impairments, as indicated by self-report * Individuals who are pregnant or expect to become pregnant during the course of the study * Individuals with claustrophobia, or the inability to lie supine position in the MRI scanner * COPD with oxygen dependence * Non-MRI compatible metal implants (surgical clips or staples, cardiac pacemakers etc.) Non-PD Control Participants Inclusion Criteria: * Subjects above 18 years of age * Age matched to participants in PD group Exclusion Criteria: * Diagnosis of Parkinsons Disease or other movement disorder * Untreated neuropsychiatric disorders * Uncorrected visual or hearing impairments, as indicated by self-report * Individuals who are pregnant or expect to become pregnant during the course of the study * Individuals with claustrophobia, or the inability to lie supine position in the MRI scanner * COPD with oxygen dependence * Non-MRI compatible metal implants (surgical clips or staples, cardiac pacemakers etc.)
Where it's running
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Medical University of South Carolina
Charleston, South Carolina, United States Recruiting
Study contacts
- Principal investigator: Daniel H Lench, PhD — Medical University of South Carolina
- Study coordinator: Daniel H Lench, PhD
- Email: lenchd@musc.edu
- Phone: 843-792-9115
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.