Clinical trial Recruiting at 1 site Interventional Ages 21 and up

Adaptive treatment for smokers struggling to quit

Official title: A Clinical Trial of Adaptive Treatment for Early Smoking Cessation Relapse

Run by Medical University of South Carolina · NCT06118502 · Data updated 2026-11-12

This study is testing different ways to help smokers in Alabama and South Carolina quit by giving them free medications and adjusting their treatment based on how they're doing over 12 weeks.

Quick facts

Study typeInterventional
Ages21 Years and up
SexAll
Enrollment544 (estimated)
SponsorMedical University of South Carolina
Academic / other
Locations1 site (Charleston, South Carolina)
StatusRecruiting
StartedMarch 25, 2024
Main results expectedDecember 1, 2027
Study endsMarch 31, 2028
Registry record updatedAugust 12, 2026
Trial IDNCT06118502 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are smokers who are motivated to quit and willing to participate in a structured treatment program.

Probably not a fit

Non-smokers will not benefit from this study as it is specifically designed for individuals seeking to quit smoking.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research focuses on improving treatment decision-making for smokers who have difficulty quitting using medications. Participants will receive free nicotine replacement therapies, varenicline, or e-cigarettes for 12 weeks, with treatment adjustments based on individual responses. The study will involve remote assessments and follow-ups, with participants completing surveys at various intervals to evaluate treatment effectiveness. A total of 544 smokers from Alabama and South Carolina will be recruited and randomized to receive different treatment combinations.

Why it matters

Potential benefit: If successful, this approach could significantly enhance smoking cessation rates among individuals who struggle to quit.

How similar studies have gone: Other studies have shown promise in adaptive treatment approaches for smoking cessation, indicating potential for success in this novel methodology.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Smokers who want to quit

Exclusion Criteria:

* Non-smokers

Where it's running

  • Medical University of South Carolina
    Charleston, South Carolina, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.