Adaptive treatment for smokers struggling to quit
Official title: A Clinical Trial of Adaptive Treatment for Early Smoking Cessation Relapse
Run by Medical University of South Carolina · NCT06118502 · Data updated 2026-11-12
This study is testing different ways to help smokers in Alabama and South Carolina quit by giving them free medications and adjusting their treatment based on how they're doing over 12 weeks.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 21 Years and up |
| Sex | All |
| Enrollment | 544 (estimated) |
| Sponsor | Medical University of South Carolina Academic / other |
| Locations | 1 site (Charleston, South Carolina) |
| Status | Recruiting |
| Started | March 25, 2024 |
| Main results expected | December 1, 2027 |
| Study ends | March 31, 2028 |
| Registry record updated | August 12, 2026 |
| Trial ID | NCT06118502 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are smokers who are motivated to quit and willing to participate in a structured treatment program.
✕Probably not a fit
Non-smokers will not benefit from this study as it is specifically designed for individuals seeking to quit smoking.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This research focuses on improving treatment decision-making for smokers who have difficulty quitting using medications. Participants will receive free nicotine replacement therapies, varenicline, or e-cigarettes for 12 weeks, with treatment adjustments based on individual responses. The study will involve remote assessments and follow-ups, with participants completing surveys at various intervals to evaluate treatment effectiveness. A total of 544 smokers from Alabama and South Carolina will be recruited and randomized to receive different treatment combinations.
Why it matters
Potential benefit: If successful, this approach could significantly enhance smoking cessation rates among individuals who struggle to quit.
How similar studies have gone: Other studies have shown promise in adaptive treatment approaches for smoking cessation, indicating potential for success in this novel methodology.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Smokers who want to quit Exclusion Criteria: * Non-smokers
Where it's running
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Medical University of South Carolina
Charleston, South Carolina, United States Recruiting
Study contacts
- Study coordinator: Tracy T Smith, PhD
- Email: smithtra@musc.edu
- Phone: 8438725164
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.