Adaptive treatment for smokers struggling to quit

A Clinical Trial of Adaptive Treatment for Early Smoking Cessation Relapse

NA · Medical University of South Carolina · NCT06118502

This study is testing different ways to help smokers in Alabama and South Carolina quit by giving them free medications and adjusting their treatment based on how they're doing over 12 weeks.

Quick facts

PhaseNA
Study typeInterventional
Enrollment544 (estimated)
Ages21 Years and up
SexAll
SponsorMedical University of South Carolina (other)
Locations1 site (Charleston, South Carolina)
Trial IDNCT06118502 on ClinicalTrials.gov

What this trial studies

This research focuses on improving treatment decision-making for smokers who have difficulty quitting using medications. Participants will receive free nicotine replacement therapies, varenicline, or e-cigarettes for 12 weeks, with treatment adjustments based on individual responses. The study will involve remote assessments and follow-ups, with participants completing surveys at various intervals to evaluate treatment effectiveness. A total of 544 smokers from Alabama and South Carolina will be recruited and randomized to receive different treatment combinations.

Who should consider this trial

Good fit: Ideal candidates are smokers who are motivated to quit and willing to participate in a structured treatment program.

Not a fit: Non-smokers will not benefit from this study as it is specifically designed for individuals seeking to quit smoking.

Why it matters

Potential benefit: If successful, this approach could significantly enhance smoking cessation rates among individuals who struggle to quit.

How similar studies have performed: Other studies have shown promise in adaptive treatment approaches for smoking cessation, indicating potential for success in this novel methodology.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Smokers who want to quit

Exclusion Criteria:

* Non-smokers

Where this trial is running

Charleston, South Carolina

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Cigarette Smoking, Smoking Behaviors, Treatment

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.