GLP‑1/GIP medications and stomach contents after fasting
Official title: An Observational Study to Examine Non-inferiority of the Standard ASA Fasting Guidelines Versus 24-hour Clear Liquid Diet for Gastric Volume in Patients Taking GLP-1 Agonists
Run by Medical University of South Carolina · NCT07251803 · Data updated 2026-11-12
This check will see if adults taking GLP‑1 or GLP‑1/GIP medicines have more stomach contents than expected after standard fasting or a 24‑hour clear‑liquid diet before elective procedures.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | Medical University of South Carolina Academic / other |
| Locations | 1 site (Charleston, South Carolina) |
| Status | Recruiting |
| Started | February 3, 2026 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | February 25, 2026 |
| Trial ID | NCT07251803 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults (18+) who have taken a GLP‑1 or GLP‑1/GIP medication within the past 30 days and are scheduled for elective surgery with standard fasting or for elective colonoscopy after 24 hours of clear liquids.
✕Probably not a fit
People with prior gastric or esophageal surgery, abnormal gastric anatomy, pregnancy, inability to provide written informed consent, or who do not speak English are excluded and likely will not benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults on GLP‑1 or GLP‑1/GIP medications who are scheduled for elective surgery (NPO ≥8 hours) or elective colonoscopy (clear liquids ≥24 hours) will receive a bedside gastric ultrasound prior to their procedure. A trained anesthesiologist will image the gastric antrum in supine and right lateral decubitus positions, measure the antral cross‑sectional area, and calculate gastric volume using a published formula (GV = 27.0 + 14.6*CSA - 1.28*age). The study will identify retained gastric contents (defined as >1.5 mL/kg or Antral Grade 2) despite adherence to fasting or liquid‑only diets. Results will compare how often retained gastric contents occur between the two preprocedure preparation groups.
Why it matters
Potential benefit: If successful, the results could help doctors decide whether extra precautions are needed for people taking GLP‑1/GIP medicines before procedures.
How similar studies have gone: Gastric ultrasound has been used successfully to detect retained gastric contents in other settings, but applying it specifically to people on GLP‑1/GIP medications is relatively new and limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18+ * Have taken a GLP-1 or GLP-GIP agonist medication within the past 30 days * ASA Physical Classification Status 1-3 * Fall into one of the following groups: 1. Scheduled elective surgery and meet ASA fasting guidelines (NPO for at least 8 hours prior) 2. Scheduled elective colonoscopy and have been on a clear liquid diet for at least 24 hours prior Exclusion Criteria: * Previous gastric or esophageal surgery * Abnormal gastric anatomy * Pregnancy * Unable to provide written, informed consent * Non-English speaking
Where it's running
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Medical University of South Carolina
Charleston, South Carolina, United States Recruiting
Study contacts
- Principal investigator: Christopher Wolla, M.D. — Medical University of South Carolina
- Study coordinator: Haley Nitchie, MHA
- Email: nitchie@musc.edu
- Phone: 843-792-1869
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.