GLP‑1/GIP medications and stomach contents after fasting
An Observational Study to Examine Non-inferiority of the Standard ASA Fasting Guidelines Versus 24-hour Clear Liquid Diet for Gastric Volume in Patients Taking GLP-1 Agonists
This check will see if adults taking GLP‑1 or GLP‑1/GIP medicines have more stomach contents than expected after standard fasting or a 24‑hour clear‑liquid diet before elective procedures.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Medical University of South Carolina Academic / other |
| Locations | 1 site (Charleston, South Carolina) |
| Trial ID | NCT07251803 on ClinicalTrials.gov |
What this trial studies
Adults on GLP‑1 or GLP‑1/GIP medications who are scheduled for elective surgery (NPO ≥8 hours) or elective colonoscopy (clear liquids ≥24 hours) will receive a bedside gastric ultrasound prior to their procedure. A trained anesthesiologist will image the gastric antrum in supine and right lateral decubitus positions, measure the antral cross‑sectional area, and calculate gastric volume using a published formula (GV = 27.0 + 14.6*CSA - 1.28*age). The study will identify retained gastric contents (defined as >1.5 mL/kg or Antral Grade 2) despite adherence to fasting or liquid‑only diets. Results will compare how often retained gastric contents occur between the two preprocedure preparation groups.
Who should consider this trial
Good fit: Ideal candidates are adults (18+) who have taken a GLP‑1 or GLP‑1/GIP medication within the past 30 days and are scheduled for elective surgery with standard fasting or for elective colonoscopy after 24 hours of clear liquids.
Not a fit: People with prior gastric or esophageal surgery, abnormal gastric anatomy, pregnancy, inability to provide written informed consent, or who do not speak English are excluded and likely will not benefit from participation.
Why it matters
Potential benefit: If successful, the results could help doctors decide whether extra precautions are needed for people taking GLP‑1/GIP medicines before procedures.
How similar studies have performed: Gastric ultrasound has been used successfully to detect retained gastric contents in other settings, but applying it specifically to people on GLP‑1/GIP medications is relatively new and limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18+ * Have taken a GLP-1 or GLP-GIP agonist medication within the past 30 days * ASA Physical Classification Status 1-3 * Fall into one of the following groups: 1. Scheduled elective surgery and meet ASA fasting guidelines (NPO for at least 8 hours prior) 2. Scheduled elective colonoscopy and have been on a clear liquid diet for at least 24 hours prior Exclusion Criteria: * Previous gastric or esophageal surgery * Abnormal gastric anatomy * Pregnancy * Unable to provide written, informed consent * Non-English speaking
Where this trial is running
Charleston, South Carolina
- Medical University of South Carolina — Charleston, South Carolina, United States (Recruiting)
Study contacts
- Principal investigator: Christopher Wolla, M.D. — Medical University of South Carolina
- Study coordinator: Haley Nitchie, MHA
- Email: nitchie@musc.edu
- Phone: 843-792-1869
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.