Neural-Precision Neurorehabilitation Center: Core Research Program
Official title: Neuro-PRECISE Center: Research Project
Funded at Medical University of South Carolina · NIH-11413417 · Data updated 2026-11-12
A large NIH grant aims to build tools and methods to precisely identify and modulate brain circuits to improve rehabilitation outcomes for people with CNS injuries.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project start | September 15, 2025 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $513,400 |
| NIH project number | 5P50HD118628-02 |
| Project ID | NIH-11413417 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with CNS injuries who require neurorehabilitation and whose recovery could benefit from targeted circuit-based therapies.
✕Less likely to help
Patients without access to specialized rehabilitation programs or those whose injuries are outside the targeted neural circuits may see limited benefit.
What this research studies
This program brings together many subprojects over five years to create and test methods for mapping dysfunctional neural circuits and guiding targeted rehabilitation. It focuses on developing knowledge, diagnostics, and data tools to understand how brain networks recover after injury. The effort emphasizes team science to move from basic concepts to practical tools that clinicians can use with patients who have physical, cognitive, and psychosocial disabilities after CNS injury.
Why it matters
Potential benefit: If successful, patients could experience more effective, personalized rehabilitation driven by precise brain-circuit targets.
How similar studies have gone: Past neurorehabilitation work has shown that targeted neural modulation can improve function in some patients, but this program seeks to scale and standardize these approaches.
Where this research is happening
-
Medical University of South Carolina
Charleston, United States Active
Researchers
- Principal investigator: Mcteague, Lisa M — Medical University of South Carolina
- Study coordinator: Mcteague, Lisa M
Related research
Other NIH-funded projects on the same topics.
-
Il1rapl2’s role in shaping cortical wiring in autism
This project studies how a brain gene linked to autism helps form the connections in deep-layer neurons to understand why circuits develop differently in ASD.
-
Neuron-OPC Synaptic Mechanisms Shaping Myelin in Health and Disease
This project looks at how brain cells called oligodendrocyte precursor cells (OPCs) listen to neurons to shape myelin, with potential relevance for autism and related conditions.
-
Synaptic development and sleep-related brain circuits in autism
A study in mice explores how early brain circuits that help sleep become wired, hoping to understand sleep problems in autism.
-
Enteric neuron and intestinal stem cell signals shaping gut barrier
A research project from the Medical University of South Carolina explores how nerve cells in the gut talk to the lining and stem cells to defend the digestive tract, using human organoids and mouse models.
-
Glutamine and macrophage behavior in liver cancer
A funded project at a medical university aims to understand how the liver’s immune cells interact with a specific type of liver cancer by looking at metabolism, especially glutamine and ammonia.
-
Glycoprotein urine markers that signal lupus nephritis treatment response
A novel test uses urine glycoprotein patterns to show how well lupus nephritis is responding to standard treatment.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.