Comparing weekly Isotretinoin to daily Tetracycline for moderate acne treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the effectiveness and safety of weekly Isotretinoin dosing compared to daily Doxycycline for treating moderate acne vulgaris. The study will involve male and female participants aged 12 and older who have been diagnosed with moderate acne. Participants will receive either weekly Isotretinoin or daily Doxycycline over a four-month period, with assessments of acne improvement, side effects, and patient satisfaction. The trial builds on previous promising findings regarding weekly Isotretinoin dosing, seeking to validate its potential as a safer alternative to long-term antibiotic use.

Why it matters

Who can join: the full rules

Inclusion Criteria:

\- Male and Female patients, 12 years and older with a diagnosis of Moderate Acne Vulgaris

Exclusion Criteria:

* Patients who are at baseline on long-term Tetracycline antibiotics, long-term Trimethoprim-Sulfamethoxazole, or on Spironolactone for any reason
* Patients who have taken Isotretinoin in the past 6 months
* Patients with hypersensitivity to Isotretinoin or to any of its components
* Females who are pregnant, likely to become pregnant, or will be breast-feeding during the study period
* Patients with a history of major depression, mania, or psychosis with an active episode during the past year including current psychotic symptoms and/or current suicidal ideation
* Adult patients with cognitive impairment
* Patients with baseline kidney or liver disease
* Patients with baseline hypertriglyceridemia
* Patients with history of or current pseudotumor cerebri
* Patients with any clinically significant unstable medical condition which could pose a risk to the safety of the patient
* Inability or unwillingness of subject or legal guardian/representative to give informed consent

Where it's running

• Medical University of South Carolina
  Charleston, South Carolina, United States Recruiting

Study contacts

• Principal investigator: Alex Richmond, MD, MSCR — Medical University of South Carolina
• Study coordinator: Kathryn Keller, BS
• Email: kellerka@musc.edu
• Phone: 8646301689

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.