Injecting steroids to treat chronic cough

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effectiveness of intramuscular steroid injections in treating patients with unexplained chronic cough. It is designed as a prospective, placebo-controlled, single-blind, randomized clinical trial where participants will receive either a steroid injection or a placebo. The outcomes will be assessed using patient-reported measures, including the Leicester Cough Questionnaire and a visual analogue scale for symptom severity. The study also aims to document any adverse reactions to the treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* History consistent with chronic unexplained or refractory cough
* Age ≥ 18

Exclusion Criteria:

* Current smokers
* Uncontrolled diabetes (A1c\>7%)
* Patients on ACE inhibitors or Angiotensin II receptor blockers (ARBs)
* Abnormal pulmonary function testing (PFTs) since start of the cough
* Patients with uncontrolled obstructive sleep apnea
* Abnormal chest X-ray within past 6 months
* Uncontrolled reflux
* Prior superior laryngeal nerve injection
* Current neuromodulating medication use for chronic cough\*

Where it's running

• Medical University of South Carolina
  Charleston, South Carolina, United States Recruiting

Study contacts

• Principal investigator: Lauren Howser — Medical University of South Carolina
• Study coordinator: Kirsten Meenan
• Email: meenan@musc.edu
• Phone: 843-792-6755

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.